剪接体

剪接体组装与转录同步进行，提示DNA结构可能直接影响可变剪接。

Spliceosome assembly occurs co-transcriptionally , raising the possibility that DNA structure may directly influence alternative splicing .

出生后大鼠牙胚组织中nfic基因多种选择性剪接体的克隆研究

Analysis of multiple alternative spliceosome of nfic gene in postnatal rat molar tissues

黏附分子CD（44）变异剪接体6在甲状腺肿瘤中的表达及其临床意义

Expression of cell adhesion molecule ( CD_ ( 44V6 )) in thyroid tumors and its significance

鉴定9个新的RHD基因mRNA可变剪接体

Identification of Nine Novel Alternative Splicing Isoforms of RHD mRNA

两种存活蛋白变异剪接体在HeLa细胞中的表达定位及相互作用

Expression and Location of Two Survivin Splice Variants and Their Interaction in HeLa Cells

N端测序显示HAPO蛋白是糖蛋白4（proteoglycan4，PRG4）的一个不同剪接体形式。

N-terminal sequencing shows that the native protein is one of the alternative splicing products of proteoglycan 4 ( PRG4 ) .

结论脐血瘦素浓度降低和胎盘瘦素、OBR受体表达低下与胎儿生长受限密切相关，脐血瘦素可能通过与不同剪接体的受体结合实现对胎儿生长发育的调控作用。

Leptin in cord blood may have an important role in regulate fetal growth and development through different OB R.

结论两种不同类型ING1剪接体过量表达对肿瘤细胞生长具有不同影响。

Conclusions Expression of two different transcripts of ING1 may have different effects on tumor cell growth .

细胞凋亡相关新基因Apr-3的一个转录剪接体的克隆、初步表达及纯化

Cloning , preliminary expression and purification of a transcript variant of the new apoptosis related gene Apr-3

马慢病毒受体1插入型选择性剪接体的原核表达

Procaryotic Expression of Inserted Alternative Splicing Variants in Equine Lentivirus Receptor-1

除全长胞外区以外，还克隆到两个新的差异剪接体。

Besides the full-length soluble cDNA , two new splicing variant were cloned .

黄牛睾丸特异乳酸脱氢酶-C基因选择性剪接体的克隆与序列分析

Cloning and Sequence Analysis of Multiple Splice Variants of Lactate Dehydrogenase C in Cattle Testes

剪接体亚型在正常组织中抑制微血管的生长。因此。

VEGF-A splice isoforms in normal tissues inhibit growth of microvessels . Thus , it is th .

在同一种组织中这两种剪接体的平均光密度比值无显著性差异（P>0.05），但在癌组织与正常粘膜组织中均有显著性差异（P<0.01）；

Difference between the 2 mRNA splices was not significant in the matched tissues ( P > 0.05 ) .

这种定位上的差异也预示着其功能上的不同，因此有必要进一步对这些可变剪接体的功能进行深入的研究。

The difference of subcellular localization implies different functions thus renders further study on these alternatively spliced variants necessary .

剪接体的出现让插入子不再需要自行剪接，结果等于鼓励插入子增生、突变与演化。

By freeing introns from the need to splice themselves , the spliceosome would in effect have encouraged introns to proliferate , mutate and evolve .

到目前为止，研究发现人类survivin存在5种不同的剪接异构体。

Until now , five splice variants of survivin have been found in humans .

肾透明细胞癌转移相关的CD99选择性剪接异构体的筛选

Identification of metastasis-associated alternatively spliced variants of CD99 in clear cell renal cell carcinoma tissues

干扰素调节因子剪切的剪接异构体IRF-3c的结构及功能

Structure and function of a truncated spliced isoform of interferon regulatory factor IRF-3c

TCF-4及其剪接异构体的过度表达和异常调控与肿瘤的发生发展密切相关。

The overexpression , the abnormal regulation of TCF-4 , and its splicing isoforms have closely relationships with the tumors .

目的探讨人结肠癌组织中是否存在环加氧酶2（COX2）选择性剪接异构体的表达及其可能意义。

Objective To explore the expression of cyclooxygenase 2 ( COX 2 ) alternative splice variant in human colon cancer tissue and its possible significance .

在全基因组层面上阐明基因及外显子的表达水平，尤其是鉴定新的剪接异构体，RNA-seq具有独特的优势。

RNA-seq is a powerful tool for comprehensive characterization of whole transcriptome at both gene and exon levels and with a unique ability of identifying novel splicing variants .

以选择性剪接蛋白异构体为靶点或干预选择性剪接过程，可望进行肿瘤的分子治疗。

It is possible for molecular therapy to target directly isoforms of protein produced by alternative splicing or to interfere with the process of alternative splicing .

SR蛋白是具有帮助识别正确剪接位点并促进剪接体的成熟的一类重要剪接因子，为组成性剪接所必需，在选择性剪接中更起着不可替代的作用。

SR protein is a kind of splicing factors that help recognition splicing site correctly and promote mature of splicesome , they are essential to constitutive splicing and have pivotal contribution to alternative splicing .

通过EST分析和特异引物扩增的方法，我们还发现HN1至少在肝、脑等组织通过不同剪接方式产生三个不同长度的差异剪接体。

By EST data analysis and specific primer amplification , we proved that HNl can produce three different splicing transcript in human tissues including liver , brain etc.