锌指结构

一直以来，锌指结构域都被认为参与DNA结合并在转录因子中存在。

In the past , zinc finger domain was thought to be involved in the ability of DNA binding and present in transcription factors .

应用简并引物RT-PCR扩增锌指结构域筛选新基因

Identification of New EST and Genes with Zinc Finger Motif by RT-PCR Using Degenerate Primers

进一步用部分物种Ikaros的保守区进行同源性比对，发现同源性较高的区域主要集中在N、C末端的锌指结构域。

Further comparison between some species and Ikaros reveals that the regions that show higher homology focus zinc finger domains at N and C-terminal .

σ3蛋白的N-末端有锌指结构域，C-末端有dsRNA连接区。

A3 protein had Zinc finger domain at amino-terminal and dsRNA binding domain at carboxy-terminal .

蛋白质对DNA识别的模体中，除了锌指结构、螺旋转角螺旋、亮氨酸拉链和β带外，近年来发现，Ⅱ型限制性内切酶与DNA作用的模体有许多特别之处。

The motif of interaction between type - ⅱ restriction endonuclease and DNA is found to be different from zinc-finger , helix-turn-helix , leucine-zipper and β - ribbon in protein recognizing DNA in the last few years .

我们鉴定了SCAN-（C2H2）X基因会在其羧基端截除锌指结构域。

It is firstly characterized for the SCAN - ( C2H2 ) X genes to truncate the zinc finger domains at the carboxyl terminus .

TAT蛋白质转导结构域与SV40启动子特异的三锌指结构融合蛋白的表达与纯化

Expression and Purification of the Fusion Protein of TAT Protein Transduction Domain with a Zinc Finger that Specific to SV40 Promoter

该基因编码产物至少含有五个C2H2型锌指结构。

Results : One of them was a novel cDNA gene , which encoding product containing five C2H2-type zinc finger domain at least .

它编码的蛋白质全长499个氨基酸，含12个C2H2型的锌指结构域。

The gene is on mouse chromosome 15 and comprises 2 exons and encodes a protein of 499 amino acid residues with 12 C2H2 type zinc fingers .

Ikaros基因编码锌指结构蛋白，是重要的血细胞分化相关因子，同时也是白血病发生的肿瘤抑制剂。

Ikaros encodes a zinc finger protein that is essential for hematopoiesis and that acts as a tumor suppressor in leukemia .

结论P9基因TRAF型锌指结构域编码的蛋白质能够在原核细胞中表达，并能获得具有特异免疫反应性的P9-ZFD多克隆抗体。

Conclusions The protein coded by P9-ZFD can be expressed in prokaryocyte . Polyclonal antibody of P9-ZFD which has peculiar immunoreactive can be prepared .

nanos基因编码一个具有锌指结构的蛋白，在生殖干细胞全能性调控方面起着重要作用。

The nanos gene encodes a Zinger-finger protein , it plays critical role in maintaining the totipotency of germline stem cells .

ie-2和pe-38基因都是极早期表达基因，其推定的开放阅读框分别编码295和302个氨基酸，并且内部含有一个保守的锌指结构和亮氨酸拉链。

Pe-38 and ie-2 are immediate early regulator genes which their ORFs encoded 286 and 302 amino acides separately , they also had a conserved zinc finger and a leucine domain separately .

锌指结构：最普遍的核酸识别元件

Zinc finger : The most common motif for nucleic acids recognition

它含有一个锌指结构和五个保守序列。

It contained a zinc-binding domain and five conserved regions .

重症肌无力相关基因P9TRAF型锌指结构域的表达及抗体制备

Expression and Antibody Preparation of the TRAF-type Zinc Finger Domain of Myasthenia Gravis Related Gene P9

本研究在感染了伊波拉病毒和马尔堡病毒的细胞中检验了锌指结构抗病毒蛋白的抗病毒效能。

In this study ZAP was tested for its antiviral activity in cells infected with EBO and MAR.

一些在组织和细胞分化中起重要作用的蛋白质包含锌指结构域。

Some of proteins associated with differentiation and development of cells and tissues contain zinc finger domain .

最近有研究发现，锌指结构域也能够参与蛋白与蛋白的相互作用。

Recently , however , it has been proved that zinc finger domain was also related with the protein-protein interaction .

真核生物中的许多蛋白质分子包含锌指结构区，这类蛋白称为锌指蛋白。

A number of proteins in eucaryon contain zinc finger domains and this class of proteins are called as zinc finger proteins .

随着基因组测序计划的不断完成，也有越来越多的具有锌指结构的锌指蛋白基因被发现。

With development of genome sequencing project , more and more zinc finger protein genes will be discovered , some of which may be novel type .

Zn2+对其活性没有明显的抑制作用，说明该激酶缺少某些哺乳动物的蛋白激酶常含有的锌指结构。

Zn 2 + had no obvious effect on its activity , indicating that this protein kinase has no zinc_finger domain that exists in some mammalian protein kinases .

为了研究Pns11的核酸结合活性，构建了两个位于可能的锌指结构内的点突变以及四个分别删除部分碱性区氨基酸片段的缺失突变。

In order to clarify the characterization of the nuclear acid binding properties , we constructed two site-specific mutations within the putative zinc finger motif and four partial deletions of the basic regions , all of which were proved by sequencing .

PHDfinger（planthomeodomainfinger）是具Cys4HisCys3特征结构的锌指蛋白结构域，它广泛存在于植物或动物转录调节蛋白中。

PHD-finger ( plant homeodomain finger ), a unique Cys_4-His-Cys_3 pattern zinc-containing domain , is widely found in many transcriptional regulation proteins from plants or animals . This protein has many different family members distributing in plant or animal proteome , and plays key roles in the development .

三维结构模拟显示该锌指保守结构域与水稻耐盐锌指蛋白OSISAP1结构域空间结构一致。

Protein 3D structure simulation showed that the zinc finger domain is similar with that of rice .

推定的氨基酸序列含有锌指样结构域、脯氨酸丰富区及脯氨酸、谷氨酰胺丰富区。

The human Hrs also contained a zinc finger like domain , a proline rich region and a proline and glutamine rice region .

一个拟南芥C2H2锌指蛋白的结构域分析

Domain function analysis of an Arabidopsis C2H2 zinc finger protein

结果表明N端的类似锌指蛋白的结构不是结合核酸的活性位点，部分缺失C端的碱性氨基酸也不影响其结合。

Our results suggest that the putative zinc finger motif in the N-terminal is not essential to the binding and that partial deletions of the basic regions in the C-terminal also cannot prevent the proteins from binding nuclear acids .

SU-PERMAN类锌指蛋白只含有1个锌指结构。

SUPERMAN-like zinc finger protein gene has only one " finger like " motif .

植物锌指蛋白是一类庞大的蛋白家族，通过锌指结构与DNA.RNA或蛋白相互作用来进行基因的表达调控，其作用贯穿了植物生长发育的整个过程。

Zinc finger protein is a superfamily that involved in many aspects of plant growth and development in plants . Zinc finger proteins regulate gene expression through interacting with DNA , RNA or protien with their typical zinc finger domains .