核定位序列

核定位序列（NLS）是信号蛋白分子上与入核转运相关的氨基酸序列。

Nuclear localization sequence ( NLS ) is the specific amino acid sequence on the signaling proteins to be sufficient for their nuclear translocation .

AIF蛋白N端含有线粒体定位序列MLS，C端含有氧化还原酶结构域即FAD和NAD结合区包括两个核定位序列NLS。

The N terminal of AIF protein contains mitochondrial localization sequence MLS , while C terminal contains oxidoreductase domain which is namely bonding domain of FAD and NAD that contains two nuclear localization sequences NLS .

目的构建p33ING1b核定位序列（nuclearlocatingsequence，NLS）绿荧光蛋白融合表达载体，将其转染到人胚肺纤维母细胞系MRC5，建立稳定表达该融合蛋白的细胞模型。

Objective To construct the NLS ( ING1 ) - GFP vector , transfer it into MRC-5 cells and establish a cell model expressing NLS ( ING1 ) - GFP fusion protein .

生物信息学的分析没有在该基因内部发现已知的核定位序列。

Bioinformatics analysis showed no known nuclear localization signals inside the sequence of sAC .

NFκB是一种重要的转录因子蛋白。由于其核定位信号序列被IκB所结合而限定在细胞质中。

Nuclear transcription factors of NF κ B are inhibited by I κ B proteins , which inactivate NF κ B by trapping and masking the nuclear localization sequence of it in the cell cytoplasm .

c-Abl属于非受体型酪氨酸磷酸激酶家族，是一个多结构域的复杂蛋白。含有核定位信号序列和核输出信号序列，可以在细胞核与细胞质之间穿梭。

C-Abl , a complex protein with multi-domains and functions , belongs to the non-receptor tyrosine kinase family , and it can shuttle between nucleus and cytoplasma depending on its nuclear localization signals and nuclear export signals .

结果证明Restin的入核确实与核定位信号序列以及核转运蛋白的相互作用有关。

The nuclear localization of Restin is substantially associated with interactions between NLS and nuclear transport protein .