造血重建

NK细胞促进小鼠MHC半相合骨髓移植后造血重建的实验研究

Experimental study on NK cells promoting donor marrow engraftment and hematopoietic reconstitution after MHC haploidentical BMT in mice

目的探讨将纯化的供鼠NK细胞加入预处理方案对主要组织相容性复合物（MHC）半相合小鼠骨髓移植（BMT）后造血重建的影响。

Objective To explore the effect of donor derived NK cells added to pretreatment conditioning regimen on hematopoietic reconstitution after MHC haplotype mismatched BMT in mice .

结果：移植+13d获造血重建，同时DNA指纹图提示供者型。

At the same time , the DNA fingerprinting showed engraftment .

组胺H2受体拮抗剂对骨髓造血重建的影响

Effects of histamine h_2-receptor antagonists on hemopoietic reconstruction in bone marrow

45例患者均获得造血重建，经荧光标记PCR短串联重复序列DNA位点分析，全部患者移植后血细胞的DNA与供者血细胞DNA完全一致。

All 45 patients were successfully engrafted and short tandem repeats with fluorescent labeling polymerase chain reaction were analyzed , all patients with full donor chimeras .

ABO血型不合对异基因外周血干细胞移植造血重建的影响

Effect of ABO - incompatibility on reconstruction of hemopoiesis after allogeneic peripheral blood stem cell transplantation

TPO可促进辐射损伤后的造血重建，有可能解决急性放射病中血小板恢复滞后的问题。

TPO can stimulate hematopoietic recovery after radiation injury .

在干细胞回输后第2天开始使用吉粒芬5μg（kg·d），直至造血重建。

C for mobilization , and 5 μ g / ( kg · d ) of rhG-CSF was given from the next day after infusion until reconstitution of hematopoiesis .

目的：探讨在非清髓性预处理条件下，纯化的供鼠NK细胞对MHC半相合小鼠骨髓移植（BMT）造血重建的影响。

Objective To study the relationship between donor-derived NK cells and hematopoietic reconstitution after nonmyeloablative MHC haplotype-mismatched BMT in mice .

从移植前后皮肤红斑的变化，尿的改变，SLE相关的免疫指标的变化，移植后造血重建情况，移植的并发症等方面进行评价。

The therapeutic effect was evaluated by the change of skin erythema , urine protein , autoantibody , hematopoietic reconstitution and transplantation related complications .

AGM区基质细胞对异基因骨髓移植后造血重建及GVHD的影响

Study on the Effect of Stromal Cells in AGM Region on Hematopoietic Reconstruction and GVHD after ALLo-BMT

结果所有患者均获得造血重建，9例发生Ⅰ度移植物抗宿主病（GVHD），3例发生Ⅲ～Ⅳ度GVHD。

Results All patients achieved engraftment , nine patients developed grade ⅰ GVHD , three patients developed grade ⅲ ⅳ GVHD .

所有患者均获得造血重建，9例发生Ⅰ度GVHD，5例发生Ⅱ-Ⅳ度GVHD。

All patients achieved hematopoietic reconstitution , and grade ⅰ and ⅱ - ⅳ GVHD were developed in 9 and 5 patients , respectively .

进行IL-2联合-α干扰素激活自体骨髓并移植，移植后观察患者造血重建、长期无病生存率、移植相关死亡率、复发率及严重的移植相关并发症。

α The ability of hematopoietic reconstruction , rate of long - term diseases free survival ( DFS ), transplantation related mortality , recurrence rate and severe transplantation related complication were study .

目的：比较化疗+GCSF与化疗+GCSF+GMCSF二种动员方案动员外周血干细胞（PBSC）和造血重建的效果。

Objective : Comparison of efficacy between chemotherapy + G CSF and chemotherapy + G CSF + GM CSF for mobilization of PBSC and hematological recovery posttransplantation .

目的：为观察使用G-CSF提前动员供者的异基因骨髓移植方法对造血重建及GVHD发生的影响。

Objective In order to investigate the influence of hematopoietic reconstitution and incidence of GVHD after allogeneic bone marrow transplantation using donors stimulated with G CSF .

目的观察供者使用粒系集落刺激因子（GCSF）后供髓对异基因骨髓移植受者造血重建及移植物抗宿主病（GVHD）发生的影响。

Objectives In order to investigate the influence of donor marrow stimulated with lenograstim ( G CSF ) on hemotopoietic reconstitution and incidence of GVHD in the patients undergoing allogeneic bone marrow transplantation ( Allo BMT ) .

目的了解外周血干细胞移植（PBSCT）后造血重建的规律及其影响因素。

Objective To explore the rule of hematopoiesis reconstruction after peripheral blood stem cell transplantation ( PBSCT ) and analyze the correlative factors .

本研究探讨内皮细胞生长因子对骨髓移植小鼠造血重建的影响。重组腺病毒AdEGFP/hVEGF165经尾静脉注射给同基因骨髓移植BALB/c小鼠；

To investigate the effects of vascular endothelial growth factor ( VEGF ) on the recovery of hematopoiesis in post-BMT mice , the recombinant adenovirus Ad-EGFP / hVEGF_ ( 165 ) was injected into syngeneic BMT BALB / c mice via the tail vein .

腺病毒介导的hVEGF（165）基因转移促进小鼠骨髓移植后造血重建

Recombinant Adenovirus Mediated hVEGF_ ( 165 ) Gene Transfer Promotes Recovery of Hematopoiesis in post-BMT Mice

基因工程人催乳素（rhPRL）促进骨髓移植小鼠的造血重建

Hematopoietic Effects of Recombinant Human Prolactin after Syngeneic Bone Marrow Transplantation in Mice

结果移植组小鼠生存、造血重建及植入指标表达明显优于对照组（P0.05），人脐血中的CD34+细胞可植入且定居于小鼠骨髓中，并可在其中增殖、分化。

Results In terms of survival rate , hematopoiesis reconstitution and engraftment sign , the data collected from transplanted mice were significantly higher than those from control group , indicating the successful engraftment within murine bone marrow and subsequently effective proliferation and differentiation of CD34 + cells .

1例急变期患者仅获短暂MCR，移植后7个月急变期复发，1例移植后第74天因造血重建延迟而感染、出血死亡。

Another patient in BC had a short duration of MCR and relapsed at + 7 months . One patient died from severe infection and bleeding at day + 74 because of delayed reconstitution .

本研究探讨川芎嗪对骨髓移植（BMT）后小鼠骨髓中LFA1和ICAM1表达水平的影响及其促进骨髓造血重建的机制。

The objective of study was to investigate the effect of ligustrazine on the expression of LFA 1 and ICAM 1 in bone marrow and the mechanism of hematopoietic reconstitution after bone marrow transplantation ( BMT ) .

方法将8例白血病患者接受FBC预处理方案后行异基因粒细胞集落刺激因子（G-CSF）动员的骨髓和外周血干细胞联合移植，观察造血重建和移植相关的并发症情况。

Method : After receiving FBC conditioning , 8 patients with leukemia were treated with mismatched allogeneic hematopoietic stem cell transplantation of CSF-primed bone marrow plus peripheral blood stem cells . hematopoietic reconstitution and transplantation related complications were observed .

结论：川芎嗪可以明显促进骨髓移植后骨髓有核细胞表面黏附分子CD31的表达水平，这可能是其促进造血重建的作用机制之一。

In conclusion , ligustrazine enhances CD31 expression in bone marrow cells after syngenic bone marrow transplantation of mice , which may be related to the mechanisms underlying the ligustrazine accelerating hematopoietic reconstitution in syngeneic bone marrow transplantation .

目的比较无血缘关系供者外周血干细胞移植和骨髓移植在造血重建、T细胞重建、感染、移植物抗宿主病（GVHD）及疗效等的差异。

Objective To compare the hemopoietic reconstitution , immune reconstitution , infection , incidence of graft-versus-host disease ( GVHD ) and clinical outcome between unrelated donor peripheral blood stem cell ( PBSC ) transplantation and bone marrow ( BM ) transplantation for leukemias .

对22例自体外周血干细胞移植（APBSCT）的三种动员方案、采集方法及移植的外周血干细胞（PBSC）数量与造血重建关系，进行了研究。

He methods of mobilization and collection of stem cells in peripheral blood stem cells transplantation ( PBSCT ) and the association between the number of stem cells transplanted and hematopoietic recovery were studied .

方法：以C57BL-6小鼠急性放射病为模型，进行半相合小鼠骨髓移植，同时设异基因骨髓移植为对照，观察移植后小鼠存活率、造血重建、GVHD或GVL作用。

Methods : Half matched BMT was performed in C 57 BL 6 murine model of acute radiation disease to observe the survival rate , hematopoietic recovery , GVHD and GVL in the mice , controlled with unmatched allogeneic BMT group .

目的研究脐血移植（UCBT）对恶性血液病的根治性治疗；观察其长期造血重建和移植物抗宿主病（GVHD）及移植并发症发生情况。

Objective To apply umbilical cord blood stem cell transplantation ( UCBSCT ) to the treatment of hematological malignancies , and to observe the persistent hematopoietic reconstitution , graft versus host disease ( GVHD ) and transplantation related complications .