超二倍体

2例可疑癌胸水标本7号、X染色体也均表现为超二倍体。

In 2 suspicious malignant pleural fluids , both chromosomes 7 and X showed hyperdiploid .

Vero是超二倍体细胞系，染色体众数为73～75；

Vero belonged to hyperdiploid cell line and its chromosome mode was 74 ;

非整倍体率为76.19%（48／63例），以DNA超二倍体为主；

Aneuploid frequency was 76 . 19 % ( 48 / 63 cases ) , the DNA hyperdiploidy was occupied a dominant position ;

结果：（1）宫颈鳞癌、卵巢常见恶性肿瘤（浆液性及粘液性囊腺癌）、滤泡性淋巴瘤的DNA含量和超二倍体率均显著高于相应起源组织或良性肿瘤；

Results : ( 1 ) DNA contents and the ratio of hyperdiploid were higher in cervical squamous carcinoma , serous and mucinous ovarian cystadenocarcinoma and follicular lymphoma than those of their corresponding original tissues or benign lesions .

癌细胞的DNA指数为0.97～1.49，均值为1.20±0.15；非整倍体率为77.5%（31／40例），以超二倍体为主；

The results showed that ① DI valuer ranged from 0.97 - 1 . 49 with an average of 1.20 . ② Aneuploid frequency was 77.5 % ( 31 / 40 cases ), the DNA hyperdiploidy was occupied a dominant position .

结果：在0～2.0Gy剂量范围内，非整倍体率随剂量增加从21.30%增加到55.56%，超二倍体/非整倍体从8.70%增加到44.00%；

Results : After treated whole blood with 0 , 0.1 , 0.25 , 0.5 , 1.0 , 2.0 Gy γ _rays , aneuploidy rate increased from 21.30 % to 55.56 % as dose increased , so did hyperdiploid / aneuploid , which increased from 8.70 % to 44.00 % .

最常见的染色体数目改变是超二倍体，其次是三倍体，四倍体和亚二倍体。

The most common numerical alteration was hyperdiploidy .

染色体分析以超二倍体为主，核型显示为人类染色体核型。

Chromosomal analysis of the tumor cells exhibited human origin with a hyperdiploid model .

结果ALL异倍体检出率为514%（1835），其中亚二倍体8例，超二倍体10例；

Results The aberrant DNA aneuploid was found in 51 4 % of the ALL patients examined ( 18 / 35 ), which included 8 hypodiploid and 10 hyperdiploid .

结果在31例肺癌胸水癌细胞中，8号染色体出现超二倍体，4例其他肿瘤患者胸水中肿瘤细胞也出现一定比例的8号染色体超二倍体。

Results In 31 lung cancer patients examined , hyperdiploid chromosome 8 was found in the effusions . The same hyperdiploid of the chromosome was also noted in 4 cases of effusion from adenocarcinoma of breast , mesothelioma and lymphoma .

结论7、8号人染色体超二倍体改变是肿瘤患者胸腔积液细胞的主要特征，采用染色体着丝粒特异性探针的荧光原位杂交技术能够检测到胸腔积液标本中的超二倍体肿瘤细胞，并且具有较好的性能。

Conclusion Hyperdiploid of chromosomes 7 and 8 are the main characteristic of pleural effusion cells from tumor patients . FISH analysis with centromere DNA probes of chromosomes 7 and 8 could detect the hyperdiploid tumor cells in pleural effusion samples with excellent performance .