西替利嗪

西替利嗪抑制组胺诱导角质形成细胞IL-8表达

Inhibitory effect of cetirizine on expression of histamine-induced IL-8 in keratinocytes

结论：西替利嗪为一强效的竞争性H1受体阻断剂。

Conclusion : The cetirizine is an potent competitive H 1 receptor antagonist .

西替利嗪的抗组胺H1受体作用

Inhibitory effects of cetirizine on histamine H_1 receptor

不同pH与西替利嗪透皮行为的关系

Transdermal Behavior of Cetirizine Correlated with Different pH

HPLC法测定盐酸西替利嗪胶囊含量

Determination of Cetirizine Hydrochloride Capsules by HPLC

HPLC法和UV法测定盐酸西替利嗪片含量的比较研究

Comparative Study on Determination the Content of Cetirizine Hydrochloride Tablets by RP-HPLC and UY Spectrophotometry

目的：建立HPLC法测定盐酸西替利嗪片的含量。

Object : To establish an HPLC method to determine the content of cetirizine hydrochloride in tablets .

RP-HPLC测定盐酸西替利嗪的含量及相关物质

Determination of cetirizine hydrochloride and its related substances by RP-HPLC

RP-HPLC法测定盐酸西替利嗪片含量的研究

Determination of cetirizine hydrochloride in tablets by ion-pair RP-HPLC

西替利嗪干预组胺诱导的真皮成纤维细胞IL-8和MCP-1产生

The intervention effects of cetirizine on interleukin-8 and monocyte chemotactic protein-1 induced by histamine in dermal fibroblast cells

目的：介绍新一代H1受体拮抗剂西替利嗪。

OBJECTIVE : To introduce cetirizine .

对照组1单纯给予口服盐酸西替利嗪10mg，1次/d，连续服用2个月；

Control group 1 were administered with cetirizine hydrochloride 10mg / day taken once orally for 2 months ;

结果该方法测得盐酸左西替利嗪平均回收率为99.85%、RSD为0.45%。

The result is that this method determines that average recovery ratio of Levo-cetirizine Hydrochloride is 99.85 % , and RSD is 0.45 % .

治疗组与对照组分别口服西替利嗪和阿司咪唑各10mg／d×10d，并辅以0.5%可的松和1%麻黄碱滴鼻，每日2～3次。

Both groups were received nasal administrations with 0.5 % cortisone and 1 % ephedrine , bid or tid , for 10 d.

目的研究国产西替利嗪（cetirizine，CTZ）的抗Ⅰ型变态反应作用。

Objective To research on inhibitary effect of domestic cetirizine ( CTZ ) on allergy type ⅰ reaction .

方法：采用RT-PCR方法研究组胺H1受体mRNA表达，组胺及西替利嗪对IL-8mRNA表达的调节作用，并用ELISA法对分泌的IL-8进行定量。

Methods : The expression of histamine H1 receptor mRNA and IL-8 mRNA was evaluated by RT-PCR method . The concentration of IL-8 in culture supernatants of cells was measured by using ELISA kit .

目的考察西替利嗪（CET）对皮肤细胞炎症模型中单核趋化蛋白1（MCP1）表达的干预作用。

Aim To study the intervention of cetirizine on monocyte chemoattractant protein-1 ( MCP-1 ) in different cutaneous inflammation models .

治疗组给予卡介苗多糖核酸（斯奇康）隔日一次肌注，每次2mL，口服盐酸西替利嗪10mg，1次/d，连续2个月；

The patients in study group were intramuscular BCG-PSN 2mL every other day , cetirizine hydrochloride 10mg / day were taken once daily for 2 months ;

依巴斯汀组症状积分下降指数为0.79±0.26，而西替利嗪组为0.76±0.29，两组间比较差异无显著性（P0.05）。

Symptom score reducing index ( SSRI ) of ebastine group and cetirizine group were 0.79 ± 0.26 and 0.76 ± 0.29 respectively . They all showed no statistical difference between the two groups ( P 0.05 ) . No serious adverse events were observed in the two groups .

西替利嗪0.056～0.50mg·kg-1口服给药时，能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度，并可显著延长豚鼠休克反应的潜伏期及降低死亡率。

The guinea-pigs were effectively decreased reaction extent of shock and prolonged latency period of shock by orally administered cetirizine ranged from 0.056 to 0.50 mg · kg - 1 , reduced the rate of histamine induced death .

治疗组80例，采用中药和外用鲜芦荟汁，对照组40例，口服盐酸西替利嗪片及3%硼酸溶液湿敷，疗程均为30d。

80 cases in treatment group , treated with Traditional Chinese Medicine and topical aloe , 40 cases in control group , treated with cetirizine hydrochloride table and topical 3 % boric acid solution .

随机分成2组，试验组（72例）给予左西替利嗪片（5mg，po，qd）；对照组（72例）给予西替利嗪片（10mg，po，qd），均连续14d。

Seventy-two patients in treatment group were treated with levocetirizine tablets ( 5 mg , po , qd ), 72 patients in control group were treated with cetirizine tablets ( 10 mg , po , qd ), all together for 14 d.

试验组（盐酸非索非那定片，120mg）及对照组（盐酸西替利嗪，10mg），2组均每天服药1次、模拟片1片，均连服14天。

Sixty eight patients in trial group received 120 mg fexofenadine hydrochloride and one simulation tablet once daily and 72 in control group received 10 mg cetirizine hydrochloride and one simulation tablet once daily for continuous 14 days .

沙丁胺醇-西替利嗪-左旋氧氟沙星联用引起心房扑动

Atrial flutter following concomitant use of salbutamol , cetirizine and levofloxacin

毛细管电泳法测定盐酸西替利嗪糖浆中西替利嗪的含量

Determination of cetirizine in cetirizine HCl syrup by capillary zone electrophoresis

氟西汀和西替利嗪对映体的双动态吸附毛细管电色谱手性分离

Chiral Resolution of Fluoxetine and Cetirizine by Dynamically Dual-coating Capillary Electrochromatography

西替利嗪为第一代抗胺药物羟嗪的衍生物。

Cetirizine for the first generation of anti-drug hydroxyzine amine derivatives .

皮肤组胺受体表达及西替利嗪的抗炎作用机制研究

Expression of Histamine Receptor and the Anti-inflammatory Mechanism of Cetirizine in Skin

盐酸西替利嗪片的溶出度考察国产与进口盐酸西替利嗪片的溶出度比较

Comparison the dissolution of domestic and imported Cetirizine hydrochloride tablets in vitro

盐酸西替利嗪凝胶剂的制备及体外透皮特性

Studies on preparation and skin penetration in vitro of cetirizine hydrochloride gel