血清固定

血清固定（sero-resistance）：治疗后皮肤损害可迅速消退，但非梅毒螺旋体抗原血清试验却持续阳性，滴度不再下降，早期梅毒易出现血清固定；

Sero-resistance : the skin lesions of the patient will soon disappear , but the nontreponemal test remains positive and its titer will not drop any more .

梅毒血清固定可能与无症状神经梅毒有关。

Syphilitic sero-resistance may be relevant to asymptomatic neurosyphilis . 3 .

目的检测未治和血清固定梅毒患者外周血T淋巴细胞亚群及NK淋巴细胞，比较两组患者之间细胞免疫的差异。

Objective To detect the T-lymphocyte subsets and NK cells of peripheral blood in untreated and serofast patients with syphilis , and compare the differences of cellular immunity between these two groups .

这种现象谓之血清固定（sero-fixation）或抵抗（sero-resistance）。

This phenomenon is named sero-fixation or sero-resistance .

血清固定梅毒患者组外周血CD3、CD4及CD8淋巴细胞均低于对照组的检测结果（P<0.05），而NK淋巴细胞高于对照组（P<0.001）；

CD3 , CD4 and NK cells in serofast patients with syphilis were lower than those in the control patients ( P < 0.05 ), NK cells in these patients were higher than those in the control patients ( P < 0.05 ) .

应用流式细胞术检测梅毒血清固定患者外周血中CD11b+CD33+HLA-DR-MDSC的比例，同时分析MDSC比例与患者血清固定病程长短及血清固定RPR滴度之间的相关性。

Flow cytometry was used to detect CD11b + CD33 + HLA-DR - MDSC in peripheral blood of syphilitic sero-resistant patients , and analysis the relationship between the level of MDSC and sero-resistance RPR titer . Results : 1 .

在临床工作中我们常发现有部分患者经治疗后虽然临床症状完全消失，但随访过程中血清学试验在很长时间内仍然阳性，不能转阴，即表现为血清固定（serum-resistance）。

However , in clinical work , we have usually discover some patients with clinical symptoms completely disappeared after treatment , but the process of follow-up serological test is still positive for a long time , that is serum-resistance .

早期梅毒血清固定患者淋巴细胞的检测及意义

Detection of Peripheral Blood Lymphocyte Subsets in Early Sero-Resistant Syphilis Patients

梅毒血清固定病人的脑脊液及免疫功能检测

Test of Cerebrospinal Fluid and Immunological Function in Patients with Syphilis Serum-resistance

近10年梅毒血清固定患者临床分析

Clinical analysis of sero-resistance of syphilis in the past decade

目的：研究梅毒血清固定现象及其相关影响因素。

Objective : To study sero-resistance phenomenon of syphilis and correlative factors .

梅毒血清固定型研究进展

The Research Progress About Sero - fixation Type of Syphilis

结论无症状神经梅毒和免疫异常可能是引起梅毒病人血清固定的原因。

Conclusion Asymptomatic neurosyphilis and immune disorder may be causes of serum-resistance of syphilis .

未治和血清固定梅毒患者外周血淋巴细胞亚群的比较研究

Comparative Study on Peripheral Blood Lymphocyte Subsets Between Untreated and Serofast Patients with Syphilis

头孢曲松治疗早期梅毒血清固定近期疗效观察

Study on ceftriaxone and benzathine penicillin in the treatment of serofast of patients with syphilis

【研究结论】1.潜伏梅毒患者较显性梅毒患者可能更易发生血清固定。

The incidence rate of sero-resistance was higher in latent syphilis than in symptomatic syphilis . 2 .

梅毒血清固定患者脑脊液情况及外周血T淋巴细胞亚群的表达

The Statement of Cerebrospinal Fluid and the Expression of T-lymphocyte Subsets in Peripheral Blood of Syphilitic Sero-resistant Patients

7例无症状神经梅毒接受首次驱梅治疗的时间较迟，表现为血清固定或血清复发。

Cases of asymptomatic neurosyphilis got their initial treatment very late , and exhibited serofast state or serologic relapse .

目的：1、探讨不同表面抗原的T淋巴细胞和不同功能的T淋巴细胞亚群在梅毒血清固定患者外周血中表达情况。

To observe the T lymphocyte groups with different surface antigens and different cell functions in syphilitic patients with sero-fast . 2 .

结论治疗未能及时、选药不当、潜在器官梅毒和免疫异常可能是引起梅毒患者血清固定的原因。

Conclusion Not timely thrapy , error selection of drugs , potential organ syphilis and immune disorder may be causes of sero-fixation of syphilis .

【研究方法】1.对我院皮肤性病科2000年1月至2010年12月收治的有完整临床资料的119例梅毒血清固定患者进行回顾性分析。

The complete clinical data of 119 syphilitic sero-resistant patients who treated in dermatology department of our hospital were reviewed from January 2000 to December 2010.2 .

研究梅毒血清固定患者外周血自然杀伤细胞水平，探讨自然杀伤细胞与梅毒血清固定发病机制的相关性。

To observe the natural killing cells level in peripheral blood of sero-fast patients and to discuss the correlation between NK cells and sero-fast . 3 .

梅毒血清固定合并妊娠妇女使用大剂量水剂青霉素治疗安全、有效，且能控制先天梅毒的发生，改善妊娠结局。

Large dose of aqueous penicillin is an effective and safety treatment for pregnant women with syphilitic sero-resistance , can control incidence of congenital syphilis infant and improve pregnancy outcomes . 4 .

血清免疫固定电泳在骨髓瘤肾脏病患者诊断中的意义

Use of serum immunofixation electrophoresis for the diagnosis of renal diseases

偶联亲水层的牛血清白蛋白手性固定相的制备

Preparation of Bovine Serum Albumin Chiral Stationary Phase with a Hydrophilic Film

交联聚丙烯酸对牛血清白蛋白的固定化

Crosslinked Polyacrylic Acid as a Carrier for the Immobilization of Bovine Serum Albumin

人血清蛋白键合固定相的合成及DL（±）氨基酸的手性HPLC分离

Synthesis of human serum albumin immobilized stationary phase and chiral separation of DL (±) aminoacids by HPLC