蛋白聚糖

目的：观察振动刺激对关节软骨细胞的DNA合成和蛋白聚糖合成的影响，探讨机械振动负荷对维持正常的关节软骨特性的重要性。

AIM : To observe the effects of vibration stimulation on DNA and proteoglycan syntheses of articular chondrocytes and investigate the importance of mechanical vibrating loads for maintaining normal characteristics of articular cartilage .

此外，通过番红O染色评估发现在CIA模型动物中蛋白聚糖丢失更为显著。

In addition , proteoglycan loss was significant in CIA model , as assessed by Safranin O staining .

云芝多糖B对巨噬细胞膜硫酸软骨素-蛋白聚糖结合氧化修饰低密度脂蛋白的影响

Effects of coriolus versicolor polysaccharides B on macrophage surface chondroitin sulfate-proteoglycans binding oxidized low density lipoprotein

核心蛋白聚糖mRNA及其蛋白在结直肠癌中的表达

Expressions of decorin mRNA and protein in colorectal carcinoma

核心蛋白聚糖对鼠肌腱细胞I型胶原及其mRNA的影响

Effects of decorin on collagen type I of rat tendon cells and its mRNA expression in vitro

谷胱甘肽对Cu~（2+）-H2O2导致关节软骨蛋白聚糖降解的影响

Effect of glutathione on degradation of proteoglycan of articular cartilage treated by cu ~ ( 2 + ) - h_2o_2

软骨细胞外基质（ECM）富含蛋白聚糖、糖胺聚糖、Ⅱ型胶原蛋白及其它成分。

Cartilage matrix is rich in proteoglycan , glycosaminoglycan , type - ⅱ collagen and other components .

纤维化的主要特征是细胞外基质（Extracellularmatrix，ECM）的过度沉积，ECM主要包括胶原、非胶原糖蛋白以及蛋白聚糖。

The major feature of fibrosis is the excess deposition of ECM ( extracellular matrix ), which includes collagen , non-collagen glucoprotein and proteoglycans .

Ⅰ，Ⅱ型胶原及聚集蛋白聚糖mRNA及细胞膜整合素β1的表达亦无明显差异；纤维环细胞可以黏附于硅橡胶膜上生长。

The cells growing in different substrates expressed the same levels of collagen type ⅰ,ⅱ and aggrecan mRNA and integrin β 1.AF cells grew well on silicone membranes .

目的探讨可溶性脑蛋白聚糖（proteoglycan，PG）与脑发育的关系。

Objective To analyze the relationship between soluble brain proteoglycan ( PG ) and brain development .

在温育的介质中加入H2O2，也可使关节软骨蛋白聚糖降解增高，Cu~（2+）或Co~（2+）对此有显著促进作用，其它过渡金属则作用不明显。

Addition of H2O2 to the incubation medium also enhanced the proteoglycan degradation of articular cartilage , and this effect was promoted significantly by Cu2 + or Co2 + .

水溶性蛋白聚糖AP-1的分离纯化和鉴定

Isolation , Purification and Identification of Polysaccharide AP 1

目的构建人软骨蛋白聚糖（aggrecan）探针，应用于整复外科研究中Northern法对AggrecanmRNA表达水平的检测。

Objective To construct Northern hybridization probe for quantitative analysis of aggrecan mRNA expression level in plastic surgery research .

目的综述硫酸乙酰肝素蛋白聚糖（heparansulfateproteoglycan，HSPG）与血管形成的关系。

Objective To review the relationship between heparan sulfate proteoglycan ( HSPG ) and angiogenesis .

核心蛋白聚糖DECORIN在肝纤维化形成机制中的作用

Study on the Role of Decorin in Liver Fibrogenesis Mechanism

T-2毒素对软骨Ⅱ型胶原蛋白和蛋白聚糖合成的影响以及硒的保护作用

Protective effect of selenium against T-2 toxin-induced inhibition of chondrocyte aggrecan and collagen ⅱ synthesis

类风湿关节炎患者蛋白聚糖aggrecanG1区特异性T细胞诱导SCID小鼠产生膝关节炎的实验研究

Induction of arthritis in SCID mice by transferring aggrecan G1-specific human T-cells from rheumatoid arthritis patients

饰胶蛋白聚糖（Decorin，DCN）属富含亮氨酸小分子蛋白多糖家族成员之一。

Decorin ( DCN ) is a member of the small leucine-rich proteoglycan gene family .

核心蛋白聚糖（decorin）在肿瘤组织中的表达及基因重组decorin的克隆与表达的研究

The Expression of Decorin in the Tumor Tissues and Recombinant Decorin Cloning and Expression

目的观察移植静脉粥样化过程，探讨蛋白聚糖（PG）对粥样化改变的影响。

Objective To observe the progress of atherogenesis in vein-grafts and explore relationship between variation of proteoglycans ( PGs ) and progress of atherogenesis .

ROS可使细胞外基质退化，表现为抑制蛋白聚糖合成及破坏细胞外基质蛋白结构与蛋白酶活性。

ROS can make the extracellular matrix degradation , characterized by inhibition of proteoglycan synthesis and destroy the structure of extracellular matrix protein and protease activity .

目的探讨核心蛋白聚糖（decorin，DCN）在小鼠牙齿发育过程中的时间和空间分布特点及意义。

Objective To study the expression of decoton ( DCN ) in the developing tooth of postnatal mice .

目的研究蛋白聚糖家族成员syndecan1分子在人多发性骨髓瘤（MM）细胞表面的表达和可溶型syndecan1分子的分泌及其调节，以期探讨syndecan1与人MM发生、发展的相关性。

Objective To analyze the expression , secretion and regulation of membrane soluble syndecan 1 in human multiple myeloma cells , and to explore the relationship between syndecan 1 and the development of human multiple myeloma .

重组腺相关病毒介导核心蛋白聚糖基因转染对SiHa细胞周期和凋亡的影响

Influences of Recombinant Adeno-associated Virus-mediated Decorin Gene Transfection on Cell Cycle and Apoptosis of SiHa Cells

目的：观察长时间异常应力环境下兔颈椎软骨终板蛋白聚糖（PG）含量及组分的变化，探讨颈椎间盘退变的发生机制。

Objective : To observe the changes of proteoglycan ( PG ) components of cervical cartilage endplate under long term abnormal stress condition and discuss the possible pathogenesis of disc degeneration .

应用小牛关节软骨短期器官温育的方法，研究了谷胱甘肽（GSH）对Cu~（2+）-H2O2导致关节软骨蛋白聚糖（PG）降解的影响。

The effect of glutathione ( GSH ) on degradation of proteoglycan ( PG ) of articular cartilage treated by Cu2 + - H2O2 was studied with incubating articular cartilage slices of new born calf .

研究表明组织蛋白酶K（cathepsinK）可降解大部分软骨基质成份，如Ⅱ型胶原、蛋白聚糖等。而滑膜的增生反应是关节结构破坏的重要参与者。

The results show that cathepsin K ( cathepsin K ) can degradation most of the cartilage matrix components , such as type II collagen , proteoglycans etc. And synovial proliferation response is an important participant in joint structural damage .

结论T-2毒素可使雏鸡关节软骨出现类关节炎改变；而且用组织化学方法检测胶原和蛋白聚糖（PG）含量，可作为骨关节病病理过程坏变或好转的生物标志。

Conclusions Osteoarthritis-like changes in chick articular cartilage can be induced by T-2 toxin , and the content of collagen and proteoglycan determined by histochemistry is an early biological markers of OA .

糖尿病大鼠肾脏蛋白聚糖Ⅱ和转化生长因子-β1mRNA的动态变化

The dynamic changes of PG ⅱ and TGF - β 1 mRNA in renal cortex of streptozotocin-induced diabetic rats

目的观察硫酸乙酰肝素蛋白聚糖（HSPG）对C3H小鼠乳腺癌移植瘤的抑制作用及其机制。

Aim To observe the anti-tumor activity and the mechanism of heparan sulfate proteoglycan ( HSPG ) on C3H mice transplanted tumors .