胍类

胍类化合物的制备及在有机合成中的应用

Preparation of Guanidines and Their Application in Organic Synthesis Cooling Compounds

3-取代色酮类化合物及五碳糖基胍类化合物的合成研究

Study on the Synthesis of 3-Substituted Chromone Derivatives and Pentosyl Guanidines

并考察了胍类高分子型抗菌剂添加量对PP力学、抗菌、阻燃性能的影响。

Investigated guanidine polymer-based antimicrobial agent addition on PP mechanical , anti-bacterial , flame retardant properties .

目的：合成1-烷基-3-[4-（苯并噻唑-2-巯基）苯基]胍类化合物，寻找有一氧化氮合酶（NOS）抑制活性的新型化合物。

Aim : To synthesize 1-alkyl-3 - [ 4 - ( benzothiazole-2-mercapto ) phenyl ] guanidine derivatives to search for new-type compounds with NOS inhibitory activity .

盐酸二甲双胍（metforminhydrochloride，简称MH）是双胍类降糖药，是目前临床应用最为广泛的降血糖药物之一。

Metformin Hydrochloride ( MH ) is a drug of the biguanides class , which is one of the most useful blood-glucose-lowering drug in clinical .

方法：随机选取90例IGT患者，分为双胍类药物治疗组、α-糖苷酶抑制剂治疗组和饮食、运动干预组。

Methods 90 IGT patients were selected in random , and divided into three groups : diet plus exercise group , Acarbose group and Metformin group .

结果和结论：合成了13个胍类化合物，其结构经IR1、HNMR、MS和元素分析得到确证；

Results And Conclusion : Thirteen guanidine compounds were synthesized , and their structures were confirmed by IR ,() ~ ( 1 ) H NMR , MS and elemental analysis .

方法对47例联合使用磺脲类、双胍类而血糖控制不好的患者每天早餐前加服4mg罗格列酮钠，进行为期12周的临床观察。

Methods A 12-week randomized , rosiglitazone sodium 4 mg / d added to 47 type 2 diabetes patients with poor glycemic control by sulfonylureas and metformin .

本研究以双胍类衍生物（简称H04）作为代谢调节剂，研究其对肉鸡生长、内分泌、免疫性能及肉品质的影响。

This thesis studied effects of guanidine derivative ( coded : H04 ) as metabolism regulator on growth , endocrine , immunity and meat quality in broiler chickens .

双胍类降糖药治疗糖尿病血乳酸水平的观察

Alteration of blood lactic acid level on biguanides therapy in diabetics

肝脏疾病患者血浆胍类化合物含量的变化

Changes of guanidino-compounds in the plasma of patients with various liver diseases

一氧化氮供体N-芳基-N′-羟基胍类化合物的合成

Synthesis of N-Aryl-N ′ - Hydroxyguanidines , a New Class of NO Donors

双胍类口服抗高血糖药是治疗2型糖尿病的主要药物种类之一；

Biguanides are commonly used oral antihyperglycemic drugs in treating type II diabetes .

本文综述了胍类化合物的合成进展。参考文献32篇。

The methods of synthesis of guanidine derivatives were reviewed with 32 references .

儿童糖尿病酮症酸中毒及双胍类药物治疗中乳酸酸中毒问题的研究

Lactic Acidosis in IDDM Children Treated with Biguanides

2型糖尿病患者双胍类药物的临床应用调查

Clinical Survey of Biguanides with Type 2 Diabetes

胍类化合物存在于许多具有生物活性的化合物中。

Guanidine moiety is an important feature commonly found in many biologically active compounds .

目前认为双胍类药物二甲双胍降低血糖但不不影响胰岛素分泌。

The biguanide metformin is believed to lower plasma glucose without affecting insulin secretion .

1-烷基-3-[4-（苯并噻唑-2-巯基）苯基]胍类化合物的合成及其生物活性

Synthesis and bioactivity of 1-alkyl-3 - [ 4 - ( benzothiazole-2-mercapto ) phenyl ] guanidine compounds

二硫戊环胍类和脒类化合物的合成及其iNOS/PAF双重抑制活性

Studies on Synthesis and iNOS / PAF Dual Inhibitory Activity of Dithiolane Guanidine and Amidine Compounds

支持向量机用于胍类化合物Na/H交换抑制活性的模式识别

Support vector machine applied to the pattern recognition of guanidines as Na / H exchange inhibitors

盐酸吡格列酮对磺脲类和双胍类药物联合治疗失效的2型糖尿病患者的疗效观察

Therapeutic effect of pioglitazone hydrochloride in type 2 diabetic patients poorly controlled with metformin and sulfonylureas

胍类化合物的合成进展

Progressing in the Synthesis of Guanidines

抗高血压药物&噻吩、呋喃、苯骈呋喃季铵盐和胍类衍生物的合成

Antihypertensive drugs : synthesis of quaternary ammonium salts and guanidine derivatives of thiophene , furan and benzofuran

有学者认为，可能是胍类衍生物，但又不具有胍类药的毒副作用。

Some scholars think that it may be guanidine derivatives , but without any toxic side-effects of guanidine drugs .

为此，近年来又开发了以固体碱和胍类有机碱为催化剂生产生物柴油的方法以及无催化的超临界状态下油脂醇解的新方法。

To solve these problems , solid base and guanidine-catalyzed transesterification methods as well as supercritical transesterification method are developed .

N-[4-（苯并咪唑-2-硫基）苯基]-N′-烷基胍类衍生物的合成和生物活性

Synthesis and bioactivity of N - [ 4 - ( benzimidazole-2-thio ) phenyl ] - N ' - alkyl guanidine derivatives

结果：糖尿病患者应用最多的药物为双胍类（40.4%），其次为磺脲类（38.9%）。

Results : Metformin was the most frequently used medicine ( 40.4 % ), followed by sulfonylurea ( 38.9 % ) .

N~1-（4-取代氨基-6-甲基-2-嘧啶基）-N~3-（对氯苯基）胍类的合成及其抗丝虫作用

Synthesis and antifilarial activity of n ~ 1 - ( 4-substituted amino-6-methyl-2-pyrimidinyl ) - n ~ 3 - ( p-chlorophenyl ) guanidines

结论一定要强调双胍类药物的禁忌症，提倡合理用药，避免滥用。

Conclusion It is important to emphasis the Contraindication of biguanides , and advocate rational use , and try to avoid abusing .