肾间质

目的初步探讨狼疮肾炎（LN）患者肾间质中肥大细胞（MCs）与肾间质纤维化之间的关系。

Objective To explore the potential relationship between the mast cells ( MCs ) in renal interstitium and the renal interstitial fibrosis in lupus nephritis ( LN ) .

结果：N株感染后期，肝血窦、肾间质和毛细血管、肺泡毛细血管含有较多的感染疟原虫红细胞，肺泡壁毛细血管内皮细胞有较多的突起与疟原虫感染红细胞相接触。

Results : Congestion and more parasite infected red blood cells in hepatic sinusoids , renal interstitium , capillaries of the liver , kidney and lungs in late period of the infection with the N strain were observed .

细胞周期素E表达与人肾间质纤维化成纤维细胞体外增殖的关系

Expression of cyclin E in the proliferation of human renal interstitial fibroblasts in vitro

肾间质纤维化的动态增强CT扫描与病理对照研究

Relative research of renal interstitial fibrosis using dynamic computed tomography contrast scan and pathology of kidney biopsy

RNA干扰在肾间质纤维化研究中的应用

Application to the Study of Renal Interstitial Fibrosis by RNAi

肾间质纤维化面积分别与BUN、Scr相关。

The area of fibrosis was positively correlated with BUN and Scr .

结果：IgA肾病中有高达86%的患者伴有不同程度肾间质损伤。

Results : Up to 86 % patients with IgA nephropathy had renal interstitial injury .

丹参酮Ⅱ-A磺酸钠对纤维化人肾间质成纤维细胞体外增殖及CyclinE蛋白表达的影响

Effect of sodium tanshinone ⅱ - A sulfonate on proliferation and cyclin E expression in human renal interstitial fibroblasts in vitro

细胞外基质（extracellularmatrixECM）合成和降解失衡，造成大量积聚是引起肾间质纤维化的主要原因。

The accumulation of extracellular matrix ( ECM ) resulting from the unbalance of synthesis and degradation is the main cause of TIF .

IgA肾病肾间质内层粘连蛋白与纤维连接蛋白局部沉积与长期预后关系的探讨

The relationship between renal interstitial laminin and fibronectin local deposition and long-term prognosis in patients with IgA nephropathy

肾间质纤维化（renalinterstitialfibrosis，RIF）几乎是所有肾脏疾病进展到终末期肾功能衰竭的共同病理途径。

Renal interstitial fibrosis ( RIF ) is the common pathologic pathway to end-stage renal failure in almost all renal disease .

PAI-1分别与FN、肾间质纤维化面积显著相关。

The level of PAI-1 was positively correlated with FN level and the area of fibrosis .

目的：探讨甘草酸18α体对梗阻性肾病大鼠肾间质中NFκB表达的影响。

AIM : To investigate the effects of glycyrrhizin-18 α on the expression of nuclear factor - κ B in the renal interstitium of rats with obstructive nephropathy .

免疫组织化学染色观察MCP-1和TGF-β1在肾间质中的表达。

The expression of MCP-1 and TGF - β 1 in renal interstitium were detected with immunohistochemistry .

目的：研究低氧条件下人肾间质成纤维细胞表达结缔组织生长因子（ConnectiveTissueGrowthFactor，CTGF）及其可能的信号途径，从而探讨低氧导致肾间质纤维化的分子机制。

Objective : To assess the expression of connective tissue growth factor ( CTGF ), and relevant mechanism for the regulation of CTGF expression by hypoxia in human renal interstitial fibroblast .

目的探讨肾间质纤维化形成过程中的肾间质细胞凋亡及其与Fas表达的关系。

Objective To investigate the way of interstitial cell loss and its possible relation to Fas expression during the course of renal interstitial fibrosis .

结论：PPARγ激动剂可抑制TGFβ诱导的肾间质成纤维细胞CTGF表达和细胞外基质（ECM）合成。

Conclusion : PPAR γ agonists may inhibit TGF - β _1-induced CTGF expression and extracellular matrix sythesis in the renal fibroblasts .

梗阻肾间质Caspase-3表达与肾纤维化程度密切相关（P<0.05）。

Caspase-3 expressions in interstitial cells of obstructive kidneys were closely related to the degree of renal fibrosis ( P < 0.05 ) .

行H-E和Masson染色，动态观察肾间质病理学改变。

The dynamic histological changes of renal interstitial tissues were observed by H-E and Masson staining .

VDR表达的进行性减少提示其与肾间质纤维化有关。

The progression of decrease in expression of VDR indicates VDR may relate to renal interstitial fibrosis .

大鼠单侧输尿管梗阻致肾间质纤维化与TGFβ1mRNA表达的关系

The relationship of unilateral ureteral obstruction-induced renal tubular interstitial fibrosis with TGF β _1 mRNA expression in rats

目的：探讨血管紧张素Ⅱ（AngⅡ）在肾间质纤维化过程中的作用机制。

To investigate the mechanism of renal interstitial fibrosis by studying the effect of angiotensin ⅱ ( AT ⅱ) on renal interstitial fibroblasts in culture .

霉酚酸酯对UUO大鼠肾间质MCP-1和TGF-β1表达的影响

The effect of mycophenolate mofetil on the expression of MCP-1 and TGF - β _1 in UUO rats

甘草酸18α体调节梗阻性肾病大鼠肾间质中CTGF和TGF-β1表达的实验研究

Effects of glycyrrhizin-18 α on expressions of CTGF and TGF - β 1 in renal interstitium in rats with obstructive nephropathy

结果辛伐他汀能抑制由TGF-β1所引起的大鼠肾间质成纤维细胞的增殖，阻止细胞由G1期进入S期。

Results Simvastatin could inhibit growth of activated rat renal interstitial fibroblasts with TGF - β 1 and arrest cells in the G1 phase .

结论：低氧可刺激人肾间质成纤维细胞表达CTGF，并且该作用依赖p38通路的活化。

Conclusion : Hypoxia could stimulate the expression of CTGF in human renal interstitial fibroblast through the activation of p38 MARK signaling pathway .

结论：PGE1可以抑制TGF-β1、CTGF的表达，减轻肾间质纤维化，从而防治梗阻性肾病。

Conclusion : PGE1 could alleviate tubulointerstitial fibrosis through inhibiting the expressions of CTGF and TGF - β 1 in tubulointerstitium .

可以抑制细胞外基质成分FN在肾间质的沉积，减少UUO大鼠肾间质纤维化面积，推测其抑制CTGF表达上调的作用可能是其抗肾小管损伤及间质纤维化的作用机制之一。

It is inferred that it may be one of mechanisms of Astragalus and Safflower mixture suppressing renal tubular damage and interstitial fibrosis .

结论：1、巨噬细胞浸润参与了UUO大鼠肾间质纤维化；

Conclusion : 1 . Interstitial macrophages infiltrate play a role in the progression of renal interstitial fibrosis .

结论甘草酸可能通过下调梗阻性肾病大鼠肾间质CTGF和TGFβ1的表达，抑制肾间质纤维化的发生。

Conclusion Glycyrrhizin-18 α may inhibit renal interstitial fibrosis in rats with obstructive nephropathy by down-regulating the expressions of CTGF and TGF - β 1 in the rat renal interstitium .