肾小球硬化

结果KA组出现明显DN病变，其肾小球硬化指数（GI）明显高于KB组（P<0.05）；

Results The glomerulosclerosis index ( GI ) in KA was much higher than that in KB group .

目的：探讨细胞型局灶节段性肾小球硬化症（Focalsegmentalglomerulosclerosis，FSGS）的病理学特征及其细胞周期调控蛋白的表达。

Objective : To investigate the morphological characteristics and expression of cell cycle regulatory proteins in cellular variants of idiopathic focal segmental glomerulosclerosis ( FSGS ) .

核因子-κB反义核酸对肾病大鼠肾小球硬化细胞凋亡的干预

Intervention of antisense oligonucleotide targeting NF - к B to apoptosis in glomerulosclerosis

前列腺素E1对肾小球硬化大鼠肾组织肝细胞生长因子的调节

Effect of prostaglandin E_1 on renal expression of HGF in glomerular sclerosis in rats

雌激素对SD大鼠肾小球硬化的影响

The Effect of Estrogen on the Glomerulosclerosis in SD Rat

目的探讨汉防己甲素对肾小球硬化大鼠肾脏转化生长因子（TGFβ1）基因表达的影响。

Aim The effect of tetrandrine on TGF - β 1 mRNA expression in glomerulosclerosis rat was observed .

糖尿病肾病（diabeticNephropathy，DN）以早期肾脏体积增大和晚期肾小球硬化为特征。

Renal hypertrophy in the early stage and glomerulosclerosis in the end stage are the characteristics of diabetic nephropathy ( DN ) .

肾小球硬化及间质炎细胞浸润的程度可作为估计UK治疗IgAN效果的指标。

Glomerular score and inflammatory cells infiltration can be used as markers to observe the effect of IgAN treatment .

改善肾小球硬化是通过减少肾小球TGFβ1表达，从而减少FN及IV型胶原生成来实现的。

Valsartan and benazepril can improve glomerulosclerosis by decreasing the expression of TGF - β 1 , FN and collagen IV in glomeruli .

肾小球硬化比例及FN在移植后较移植前降低，但无统计学意义。

Glomerular sclerosis ratio and FN after transplantation were lower than that before transplantation , but no significant difference .

糖尿病肾病（DN）是糖尿病最典型的微血管并发症之一，又称糖尿病性肾小球硬化症。

Diabetic nephropathy ( DN ) is one of the most typical diabetic microangiopathy complications , also known as diabetic glomerulosclerosis .

肾小球硬化是1型与2型DN共同的特征性肾脏病理改变。

The major renal pathological changes of diabetic nephropathy both developed from type 1 and type 2 diabetes are glomerular sclerosis .

长期糖尿病病人结节性肾小球硬化的PAS染色。

This is a PAS stain of nodular glomerulosclerosis ( Kimmelstiel-Wilson disease ) in a patient with long-standing diabetes mellitus .

目前，肾保护的研究主要从防治肾小球硬化、肾间质纤维化和肾内血管硬化等方面进行，其中减少细胞外基质（ECM）过度积聚是其核心环节。

Nowadays , studies on renal protection mainly focus on prevention and treatment of glomerular sclerosis , renal interstitial fibrosis and intrarenal vascular sclerosis etc.

MsPGN最终导致肾小球硬化，出现肾功能衰竭，是严重危害人民健康的主要肾脏疾病。

MsPGN is a major kidney disease that is harmful to human health .

MEL治疗能够部分改善肾功能，显著减少尿蛋白的排泄，延缓进入肾功能衰竭期；形态学上可以减轻系膜基质的增生、肾小球硬化和肾间质纤维化。

The melatonin could partly ameliorated renal function , predominantly reduced urinary protein excretion and retarded the appearance of renal failure .

结论：1.慢性肾脏病患者，随着肾功能的损害，血、尿Col-Ⅳ和LN的含量均明显增高，Col-Ⅳ、LN均参与了肾小球硬化的病理过程；

Conclusions : 1 . With the lesion of the renal function , the contents of serum , urinary Col-IV LN increased significantly in Chronic nephropathy patients .

而用维生素E治疗的大鼠，肾小球硬化、滤过膜增厚、肾间质纤维化和肾组织羟脯氨酸含量增高的程度显著减轻，肾小球代偿性肥大和肾小球毛细血管代偿性增生的发生时间后移。

In group C , there were significantly less severe glomerular sclerosis , filtration membrane thickening , interstitial fibrosis , and renal hydroxyproline content than in group B. As a result , the glomerular hypertrophy and glomerular capillary proliferation were postponed .

另外，DEHP或高脂饮食均可引起子代大鼠肾功能不全和肾小球硬化，并且同时暴露于DEHP和高脂饮食的子代大鼠肾脏损害现象最为严重。

In addition , DEHP or HFD induced renal dysfunction and glomerulosclerosis , and the DEHP / HFD offspring had the most serious phenomenon .

糖尿病肾病（diabeticNephropathy，DN）为糖尿病性微血管病变所引起，病理诊断名称为糖尿病性肾小球硬化症，是糖尿病的严重并发症之一。

Diabetic Nephropathy ( DN ) is due to pathological changes of diabetic capillary blood vessel , whose pathological diagnostic name is diabetic glomerular sclerosis disease . DN is one of serious syndromes of diabetic mellitus .

目的：探讨洛伐他汀对阿霉素肾病肾小球硬化大鼠基质金属蛋白酶抑制因子-1（TIMP-1）的影响。

Objective : To study the effect and mechanism of lovastatin on the expression of tissue inhibitors of metalloproteinase-1 ( TIMP-1 ) and fibronection in rat glomerulosclerosis induced by adriamycin .

目的：了解特发性局灶节段性肾小球硬化症（Focalsegmentalglomerulosclerosis，FSGS）在肾脏疾病中的构成变化及其临床病理诊断要点和意义。

Objective : To investigate the relative frequency of idiopathic focal segmental glomerulosclerosis ( FSGS ) in renal biopsy proven diseases , and its criteria and significance of clinicopathological diagnosis .

目的观察肝素钙注射液防治局灶节段性肾小球硬化（FSGS）的可能性。

Objective To observe the preventive and therapeutic feasibility of heparin calcium injection in rats with focal segmental glomerulosclerosis ( FSGS ) .

目的重新评价肾活检标本中特发性局灶节段性肾小球硬化病（FSGS）的发生率、主要临床及病理特点。

Objective To analyze the incidence , clinical presentations and pathological changes of patients with primary focal segmental glomerulosclerosis ( FSGS ) .

目的：糖尿病肾病（diabeticNephropathy，DN）是指糖尿病性肾小球硬化症，是糖尿病微血管并发症之一，其发生率随糖尿病病程的延长而增加，死于糖尿病肾病肾功能衰竭的患者逐渐增多。

Objective : Diabetic nephropathy ( DN ) is the diabetic glomerular sclerosis , also is one of microvascular complications , and its incidence increased with the duration of diabetes . Patients died of diabetic renal failure increased gradually .

结论反义TGF-β1基因真核表达载体可从分子水平阻断MsC的FN及PAI-1表达，在肾小球硬化及肾小球肾炎的研究治疗中有一定的应用价值。

[ Conclusion ] Recombinant TGF - β 1 antisense eukaryotic expression vector can inhibit the secretion of FN and PAI-1 , which may be effective in gene therapy for sclerosing glomerulonephritis and proliferative glomerulonephritis .

背景与目的：慢性肾脏疾病（CKD）进展至终末期肾衰的共同特点是肾小球硬化和间质纤维化。

Background and Objective : Diffuse glomerular sclerosis and interstitial fibrosis contribute to the progression of renal damage and are the final common pathway for almost all forms of kidney diseases .

结果模型组较对照组肾小球硬化明显，PDGFBB表达明显增强（P<0.011）；

Results Compared with those of the control group , the kidneys of the model group had more severe glomerulosclerosis and higher level of expression of PDGF BB ( P < 0.01 ) .

8w时肾脏出现减小的趋势，病理出现肾小球硬化、间质纤维化和肾小管萎缩。

At 8w post-injection , the renal size had a decreasing trend and pathological studies showed glomerular sclerosis , renal interstitial fibrosis and tubular atrophy .

目的研究血管紧张素Ⅱ（AngⅡ）灌注对大鼠足细胞裂隙膜分子nephrin表达及足细胞凋亡的影响，以及探讨AngⅡ引起蛋白尿及肾小球硬化的机制。

Objective To evaluate the effects of angiotensin ⅱ( Ang ⅱ) infusion on nephrin expression and podocyte apoptosis in vivo , and investigate the mechanism of proteinuria and glomerulosclerosis induced by Ang ⅱ infusion .