肽类抗生素

从中国武汉地区水稻白叶枯病叶上分离出一株真菌B-3543，它产生一种新的肽类抗生素，对多种革兰氏阳性和阴性细菌有抗菌活性。

A fungus strain B-3543 isolated from a rice leaf with lesion caused by bacterial leaf blight in Wuhan , China was found to produce a new peptide antibiotic which exhibited antimicrobial activity against several Gram-positive and Gram-negative bacteria , most strongly against Xanthomonas campestris pv . oryzae .

通过添加蛋白质合成抑制剂&放线菌酮的实验发现，此抑菌活性物质的合成与菌体蛋白质的合成有相关性，这与一般的肽类抗生素的性质不同。

By added protein biosynthesis inhibitor-cycloheximide to the culture medium , we discovered that the biosynthesis of the antibiotic substance has relations with synthesis of the mycelial protein . This property is different from that of the ordinary peptide antibiotic .

结论hβD3cDNA的克隆和原核表达载体的构建，为进一步制备抗耐药菌的肽类抗生素奠定了基础。

Conclusion The cloning of cDNA encoding h β D 3 and construction of its prokaryotic expression vector provide evidence for the preparation of the antimicrobial peptide .

目的克隆人β防御素3（hβD3）cDNA并构建其原核表达载体，为更深入的抗菌肽活性研究及制备新型肽类抗生素创造条件。

Objective To clone the cDNA encoding human beta defensin 3 and construct its prokaryotic expression vector for the purpose of providing evidence for further studies of the activities of antimicrobial peptides and the preparation of new type of peptide antibiotics .

酯肽类抗生素547C的研究

Studies on the depsipeptide antibiotic 547c

含硫肽类抗生素基因工程的研究

Study on the Genetic Engineering of Sulphur Containing Peptide Antibiotics

肽类抗生素对细胞选择性作用研究进展

Advances in selective action of peptide antibiotics on cells

基因工程改造生物合成肽类抗生素

Gene Engineered Biosynthesis of Peptide Antibiotics

羊毛硫抗生素是一类结构独特的肽类抗生素，因其序列中含有羊毛硫类非常规氨基酸而得名。

Lantibiotics are unique class of peptide antibiotics containing unusual amino acids , such as lanthionine and P-methyllanthionine .

目的：研究具有新型结构的胞嘧啶核苷二肽类抗生素云南霉素的抗肿瘤作用的分子机理。

Objective : To explore the molecular mechanisms of antitumor effect of yunnanmycin which is a novel cytosine nucleoside antibiotic .

脂肽类抗生素是一类重要的抗生素，具有抗菌谱广，抗菌效果佳，不容易使病原菌产生耐药性等特点。

Lipopeptide antibiotic is one important kind of antibiotics with broad spectrum and good antibacterial effect , and usually it is not easy to make pathogens resistant .

结论家蝇幼虫抗菌肽哺乳动物型工程细胞表达系统的建立，为进一步制备抗耐药菌的肽类抗生素奠定了基础。

Conclusion The establishment of mammal engineering cells for expressing the antibacterial peptide of Musca domestica larvae will lay a solid foundation for the preparations of the peptide antibiotics of Cecropin .

短杆菌肽S是迄今为止研究得最详细的一种与细胞膜发生相互作用的环状肽类抗生素.它的作用机理是破坏细胞膜结构，导致细胞内含物的释放，而最终引起细胞的死亡。

Gramicidin S is the most thoroughly studied cyclic peptide since now , its mechanism is destorying the structure of the membrane , inducing the leakage of the endocellular materials , and killing the microbial cells at last .