肽聚糖

其DNA，RNA蛋白质和肽聚糖合成也均受到明显的抑制。

In addition , the synthesis of DNA , RNA , protein and peptidoglycan was inhibited .

目的：探讨青春型双歧杆菌的完整肽聚糖（wholepeptidoglycan，WPG）的抑瘤机制。

Objective : To explore the antitumor mechanisms of whole peptidoglycan ( WPG ) of adolescence bifidobacteria .

目的：研究乳杆菌肽聚糖（PG）的抑瘤作用及其机制。

Objective : To investigate the antitumor effect of lactobacillus peptidoglycan ( PG ) and explore its possible mechanisms .

结论千里光的抗金黄色葡萄球菌作用机制可能是通过抑制细菌的DNA，RNA，蛋白质和肽聚糖的合成有关，其作用的有效成分可能是黄酮类化合物。

ConclusionThe antibacterial mechanism of SSB on S.aureus may be involved with the inhibition of DNA , RNA , protein and peptidoglycan synthesis , its effective ingredients may be flavonoid compound .

双歧杆菌的全肽聚糖对裸鼠腹腔巨噬细胞产生IL-6、IL-12及一氧化氮的影响

Influence of whole peptidoglycan of bifidobacterium on interleukin 6 , interleukin 12 and nitric oxide produced by peritoneal macrophages of nude mice

肽聚糖识别蛋白（Peptidoglycanrecognitionprotein，PGRP）是一类模式识别受体，在昆虫的先天性免疫反应中起着重要的作用。

Peptidoglycan recognition protein is an important pattern recognition receptor and play an important role in the insect innate immune response .

在41个推定基因中，预测出编码DNA末端酶大亚单位、DNA解旋酶B亚单位、肽聚糖结合蛋白及3个尾丝蛋白等6个基因的功能。

Among 41 predicted genes , 6 genes which encode terminase large subunit , including DNA Gyrase B subunit , peptidoglycan binding protein and 3 tail fiber proteins , were functionally known by analysis of bioinformatics .

细胞壁膜的主要组分肽聚糖（PEG）层、外膜和内膜是细胞壁膜吸附Cu2+的主要场所。

The cell the peptidoglycan ( PEG ) layer , outer and inner membranes were the main components of cell adsorption of to the Cu2 + .

革兰阳性菌肽聚糖对人嗜碱性粒细胞中TLR3、TLR9mRNA的上调作用

Up-regulatory Effect of Peptidoglycan on the Expressions of TLR_3 and TLR_9 mRNA in Human Basophils

A3α肽聚糖对牙鲆不同组织中超氧化物歧化酶及磷酸酶活性的影响

Effect of A3 α peptidoglycan ( PG ) on SOD , ACP , and AKP activities in different tissues of Japanese flounder Paralichthys olivaceus

结果显示完整肽聚糖注射组大肠癌移植瘤bcl－2蛋白表达率及阳性细胞密度均低于肿瘤对照组，bax基因的表达情况则相反。

The results showed that the expression rate and positive cell density of bcl-2 oncoprotein were significantly lower in the WPG injection group when compared with the tumor control group .

结论分叉双歧杆菌的完整肽聚糖体内能明显降低结直肠癌PTK和PKCα的活性，同时阻止NF-κB的活化。

Conclusions WPG of bifidobacteria bifidum could markedly decrease the activity of PTK and PKC α, and inhibit the activation of NF - κ B of colorectal in vivo .

其核心结构由最内层的肽聚糖（Peptidoglycan，PG）、中间层的聚阿拉伯糖半乳糖（Aribinangalactan，AG）以及最外层的分枝菌酸（Mycolicacid）所构成。

The core of mycobacterial cell wall consists of inner layer peptidoglycan ( PG ) , middle layer arabinogalactan ( AG ) and outer layer mycolic acid .

除LPS外，CD14还介导肽聚糖（PGN）、脂磷壁酸（LTA）、脂蛋白等多种病原体成分与细胞的反应，它是天然免疫中重要的模式识别分子。

Thus , CD 14 is an important component of the innate immune system and can be defined as pattern recognition receptor .

糖尿病大鼠肺泡巨噬细胞TLR2的表达及对肽聚糖反应性的研究

Expression of Toll-like Receptor 2 in Alveolar Macrophages of Diabetic Rats and Response to PGN

从乳酸杆菌提取胞壁成分肽聚糖（PG）进行小鼠抗实体肉瘤S（180）试验，6次结果平均抑瘤率为39.8%。

The antitumor action of cell wall peptidoglycan extracted from Lactobacillus plantarum was investigated in LACA mice with sarcoma-180 , the mean percentage of tumor inhibition in 6 separate tests was 39.8 % .

乳酸杆菌胞壁肽聚糖（乳酸PG）由胚芽乳杆菌经破壁，脱脂，去杂蛋白、核酸和磷壁质酸制得；

The peptidoglycan ( PG ) of Lactobacillus plantarum was obtained from whole cell of bacteria following break of cell wall , delipidation , elimination of protein , nucleic acid and teichoic acid .

目的了解被LPS激活的裸鼠腹腔巨噬细胞在用双歧双歧杆菌的完整肽聚糖刺激后产生的NO、iNOS及cGMP的水平。

Objective To study the levels of nitric oxide ( NO ), inducible nitric oxide synthase ( iNOS ) and cGMP produced by peritoneal macrophages of nude mice after stimulation by whole peptidoglycans of Bifidobacteria bifidum .

目的：观察双歧杆菌完整肽聚糖（WPG）体外抗肿瘤作用及对大鼠大肠肿瘤的影响。

Objective : To observe in vitro and in vivo antitumor effects of whole peptidoglycan ( WPG ) from bifidobacterium on large bowel neoplasm .

细菌表面zeta电位增大，反映此类消毒剂与细菌胞壁肽聚糖结构中肽链上亚氨基和自由氨基发生酰化作用，从而致死细菌。

Increase in bacterial surface zeta potential reflected that this kind of disinfectant caused acylation of imino-group and free amino-group on peptide chain in bacterial wall peptidoglycan structure , leading to death of the bacteria .

目的研究双歧杆菌表面分子细胞壁肽聚糖（WPG）、脂磷壁酸（LTA）对LPS体内诱导小鼠胸腺细胞凋亡的调节。

Objective To investigate the regulation of Bifidobacterium bifidum surface molecules whole peptidoglycan ( WPG ), lipoteichoic acid ( LTA ) on apoptosis of murine thymocytes induced by LPS in vivo .

结论：分叉双歧杆菌的全肽聚糖能激活巨噬细胞，使之分泌多量的IL-6、IL-12及NO，这些细胞毒性效应分子介导了全肽聚糖的多种重要生理功能。

CONCLUSION : The result suggested that whole peptidoglycan of bifidobacterium bifidum could activate macrophages to secrete large amount of interleukin 6 , interleukin 12 and NO. These cytotoxicity effectors mediated many kinds of important physiological functions of bifidobacterium .

结果完整肽聚糖注射组裸鼠腹腔巨噬细胞在LPS诱导下产生的NO、iNOS及cGMP含量均显著高于对照组（P<001）。

Results The content of NO , iNOS and cGMP derived from peritoneal macrophages of nude mice induced by LPS in whole peptidoglycan injection group was significantly higher when compared with control group ( P < 0 01 ) .

meso-DAP作为细胞壁肽聚糖的主要诊断氨基酸。

The cell-wall contains meso-DAP as the major diagnostic diamino acid in the peptidoglycan .

已有的研究证明，MKP-1被诱导表达后，可以缓解由细菌脂多糖（LPS）或肽聚糖（PGN）所引起的炎症反应。

Induction of MKP-1 has been implicated in attenuating the Lipopolysaccharide ( LPS ) and Peptidoglycan ( PGN ) responses , but how the expression of the MKP-1 is regulated is still not fully understood .

肽聚糖识别蛋白（PGRPs）是一组从昆虫到哺乳动物高度保守的模式识别分子。

Peptidoglycan recognition proteins ( PGRPs ) are pattern recognition molecules coded by up to 13 genes in insects and 4 genes in mammals .

目的：探讨双歧杆菌完整肽聚糖（BWPG）对重组乙肝表面抗原（rHBsAg）诱导细胞免疫应答的影响。

AIM : To explore the effect of bifidobacterial whole peptidoglycan ( BWPG ) on cellular immune response to recombinant hepatitis B surface antigen ( rHBsAg ) .

目的探索信号途径ERK→AP-1在双歧杆菌的完整肽聚糖（WPG）激活巨噬细胞中的作用。方法以WPG刺激SD大鼠腹腔巨噬细胞，采用凝胶电泳迁移分析技术检测巨噬细胞AP-1的活性。

Objective To explore the role of whole peptidoglycan ( WPG ) of Bifidobacteria to activate macrophages in view of signal pathway ERK → AP-1.Method AP-1 activity of macrophages was detected by using electrophoretic mobility shift assay , after WPG stimulated peritoneal macrophages of SD mice .

乳酸杆菌肽聚糖对小鼠机体免疫功能的调节作用

The Influence of Peptidoglycan of Lactobacillus on Immune Function of Mouse

细菌细胞壁肽聚糖的研究进展

Advance in the research of peptidoglycan of the bacterial cell wall