肝药酶

结论：TCP能抑制小鼠肝药酶活性。

Conclusion : TCP proved to be capable of inhibiting the activity of hepatic microsomal drug-metabolizing enzymes in mice .

质子泵抑制剂盘托拉唑对大鼠肝药酶中P450的影响

Effect of Proton Pump Inhibitor-Pantoprazole on P450 in Rat Liver Microsomes

儿茶素对肝药酶和CCl4急性肝损伤的影响

Effects of EGCG on hepatic microSomal drug-metabolizing enzyme and CCl_4-induced liver injury

【目的】研究儿茶素没食子儿茶素没食子酸酯（EGCG）对肝药酶和CCl4急性肝损伤的影响。

To study the effect of Epigallocatechin gallate ( EGCG ) on hepatic microsomal drug-metabolizing enzyme and CCl4-induced liver injury .

结论：DZ选择性地抑制了AP在人体肝脏中的4羟基化代谢途径，提示DZ是一作用较强的、选择性的肝药酶抑制剂。

CONCLUSION : DZ inhibited the4 hydroxytative metabolic pathway of AP , suggesting DZ may be a potent and selective microsomal enzyme inhibitor .

在大鼠体内，甘草酸及其代谢产物均加快了大黄酸的代谢，诱导肝药酶P450，而且甘草酸的代谢产物甘草次酸对大黄酸的抑制超过了甘草酸。

In rats , glycyrrhizic acid and its metabolites act as inducers of hepatic drug metabolizing enzyme P450 , rhein accelerated the metabolism of glycyrrhizin and glycyrrhetinic acid metabolites of rhein inhibition on more than glycyrrhizin .

肝药酶包括Ⅰ相酶（细胞色素P450）和Ⅱ相酶（葡萄糖醛酸转移酶UDPG-T和谷胱甘肽-S-转移酶GSH-S-T）。在大多数情况下。

Hepatic drug metabolizing enzymes include Phase I enzyme ( Cytochrome P-450 ) and Phase II enzyme ( mainly UDPG-T and GSH-S-T ) .

生脉注射液对小鼠肝药酶的影响

Effect of Shengmai injection on mice 's liver drug metabolizing enzyme

氟喹诺酮类药对人肝药酶活性的影响

Effects of fluoroquinolones on activity of drug-metabolism enzymes in human liver microsome

六氯对二甲苯对豚鼠肝药酶的抑制作用

Inhibition of hepatic drug-metabolizing enzymes by hexachloro-p-xylene in guinea pigs

依诺沙星对大鼠肝药酶的抑制作用

Inhibition of enoxacin on drug-metabolizing enzymes in rat liver

长期服用茶多酚对大鼠肝药酶活性的影响

Effects on rat hepatic microsomal drug-metabolizing enzymes for tea polyphenols long term used

质子泵抑制剂抑酸效果与肝药酶基因型的关系

The effect of proton pump inhibitor on intragastric acidity and it relation to S-mephenytoin hydroxylase genetic polymorphism

五味子和甘草对大鼠肝药酶的诱导作用导致利多卡因药动学的改变

Evaluation of Enzyme Induction Effect of Schisandra Chinensis and Glycyrrhiza Uralensis on Pharmacokinetics of Lidocaine in Rats

白花前胡中总香豆素组分对小鼠肝药酶活性的影响

Effect of Total Coumarins from Peucedanum Praeruptorum Dunn on the Activity of Hepatic Drug-metabolizing Enzymes in Mice

目的探讨肝脏脂质过氧化反应和肝药酶活性改变与抗结核药物肝毒性的关系。

Objective To study the correlation of lipid peroxidation , P450 drug-metabolizing enzyme of liver tissue and hepatotoxicity .

感染细粒棘球蚴对宿主（羊）肝药酶的影响及肝组织超微结构的变化

Effect of Hydatid Cyst Infection on the Hepatic Drug Metabolism of Host ( Sheep ) and the Ultrastructural Changes of Liver

银杏叶提取物与其他药物合用，可能通过影响肝药酶的活性发生药物相互作用，其中银杏叶提取物对肝药酶的诱导或抑制作用的研究较为深入。

Interactions between GBE and other drugs are of increasing concern . Among these interaction , induction and inhibition of hepatic drug metabolizing enzymes by GBE have been investigated .

最后将该前处理方法应用于血清、肝药酶复杂生物体系中右美沙芬及其代谢产物去甲右美沙芬的定量测定，取得了令人满意的结果。

This approach also has been applied to determination dextromethorphan and its metabolite in human plasma and liver enzyme . The result of the experiment was satisfactory . 2 .

方法通过研究肝药酶的专属探针药物的体内代谢过程的变化，进而判断不同结构糖类药物对这些酶有无诱导或抑制作用。

METHODS The metabolic changes of midazolam as the probe drug was studied in vivo , then the inhibition or induction effects of oligo-and poly-saccharide with different structure were estimated .

[方法]观察药物对三种大小鼠动物肝炎模型，体外抗谷丙转氨酶及对肝药酶的影响。

Observation on the influence of the extract on the hepatitis in mouse and rat models , and the activities of serurn alanine amino transferase ( ALT ) and liver enzymes for drug metabolism in vitro .

利福喷丁对小鼠肝微粒体药酶的诱导作用

Induction of rifapentine on hepatic drug-metabolizing enzymes in mice

苯巴比妥诱导下大鼠肝微粒体药酶活性与膜流动性变化的相关性

Studies on correlation between liver drug metabolizing enzyme activities and microsomal membrane fluidity in phenobarbital treated rats

母源性铅接触对子代鼠肝微粒体药酶活性的影响

Influence of Lead Caused by the Mother Rats on the Hepatic Microsomal Drug-Metabolizing Enzyme Activities in the Descendant Rats

目的：观察给母鼠孕期及哺乳期饮用不同剂量的铅水后，其子代鼠肝微粒体药酶活性的变化。

The present paper investigated the alterations of hepatic microsomal drug-metabolizing enzyme activities in the descendant rats after the mother rats took in different concentrations of lead water .

结论：AGP对CCl4引起的急性肝损伤保护作用机制可能与其清除自由基、抑制脂质过氧化及诱导肝药酶有关。

Conclusion : The mechanism of protective action of AGP on CCl 4 injured liver is related to the clearing of free radicals and inhibition of lipid peroxidation .

静脉注射吡喹酮清除率的降低可归于西米替丁降低肝血流的结果，而口服PQT清除率的降低主要可能与西米替丁对肝药酶的抑制有关。

The reduction in clearance of intravenous PQT could be attributed to the result of cimetidine lowering liver blood flow , whereas the reduction in clearance of oral PQT might be related mainly to the inhibition of cimetidine on the activity of hepatic drug-metabolizing enzymes .