肝脏代谢

低分数表明肝脏代谢很可能是药物的消除机制，因而，肝脏疾病可以影响药物的消除。

A low fraction indicates that hepatic metabolism is the likely mechanism of elimination and that hepatic disease may therefore affect drug elimination .

因此，从局部到全身的延迟再分布和快速完全的肝脏代谢&且代谢产物无活性，是很有利的。

Therefore , it is favorable for a prolonged redistribution from local tissue into systemic circulation and a rapid and complete hepatic metabolism of the compounds to inactive derivatives .

体外分析表明：IHH具有正常肝细胞的主要功能，表达与肝脏代谢、解毒、合成相关的基因和蛋白。

The expressions of mRNAs and proteins involved in main functions of normal liver such as metabolism , detoxification and biosynthesis could be detected in IHH .

给予乙烯雌酚后，除对细胞色素b5无明显影响外，上述指标均可逆转。结论：老年雌性大鼠去势后肝脏代谢能力及抗氧化功能的降低与雌激素水平低下有关。

Treatment with diethylstilbestrol could reverse the changes of above indices except for cytochrome b_5 . CONCLUSION : The decreased metabolism and antioxidative functions are related to the lower level of estrogen in old castrated female rats .

当你吸烟时，它会在身体里扩散，迅速穿过肝脏代谢并释放出NNAL，然后产生NNK，进入血液。

It releases into your body when you inhale smoke , quickly passes through the liver , gets metabolized and releases NNAL , a byproduct of NNK , into the bloodstream .

胆汁是肝脏代谢活动的副产品。

Bile is produced as a byproduct of liver metabolism .

雌激素对老年雌性去势大鼠肝脏代谢能力及抗氧化功能的影响

Influence of estrogen on metabolism and antioxidative functions in old castrated female rats

结论：肝硬化时，肝脏代谢脂肪的能力已受损；

Conclusions : The ability of fat metabolism was decreased in the cirrhotic liver .

经肝脏代谢后，奥美拉唑转化为两种主要代谢产物：5-羟基奥美拉唑和奥美拉唑砜。

Omeprazole is metabolized in the liver to two major metabolites : 5-hydroxy-omeprazole and omeprazole sulfone .

鲫鱼肝脏代谢酶和血清性激素对低浓度五氯酚的响应

Response of Metabolic Enzymes in Liver and Serum Hormone of Cyprinus Carpios to Low Concentrations of Pentachlorophenol

椰子也能使肝脏代谢率最多增长30%。

Coconuts also increase the livers rate of rate of metabolism by up to 30 per cent .

结论：该模型适用于研究药物在肝脏代谢中的相互作用及其发生机制，也可用于研究某些药物特殊的代谢动力学特征。

CONCLUSION : This model is reliable and suitable for the study of metabolic drug-drug interactions occurring in the rat .

肝脏代谢药物的能力和肾脏排泄药物的能力随着年龄的增长而下降。

The abilities of the liver to metabolize drugs and of the kidney to excrete drug metabolites decline with the aging process .

酒精性脂肪肝的发病机理是进入体内的酒精90%在肝脏代谢，它能影响脂肪代谢的各个环节，最终导致肝内脂肪堆积。

ACA etiopathogenesis : 90 % alcohol in body metabolism in liver , which influence fatty metabolism each component element that result in ALD at last .

老鼠的肝部基因恢复活力不会逆转老鼠在其他方面的老化，但却有助于肝脏代谢药物或出去毒素。

The genetic rejuvenation won 't reverse other damage caused by time for the mouse , but could help its liver metabolize drugs or get rid of toxins .

背景：异丙酚是临床广泛应用的静脉麻醉药，它主要在肝脏代谢，其在体内的分布、代谢和清除受肝功能的影响；

Background : Propofol was an intravenous anesthetic agent which was employed widely in clinical practice . While hepatic metabolism was considered as the main elimination pathway of propofol .

这可能是高原低气压，缺氧对肝脏代谢的影响，调节甲状腺激素，以求机体对高原坏境的适应。

This may be the low-atmosphere at high altitude effect the liver metabolism , and regulated the Thyroid Hormone by the body in order to adapt the plateau environment .

当酒精在肝脏代谢，它创建的自由基损伤肝细胞线粒体和防止使用足量的氧气产生能量他们。

When alcohol is metabolized in the liver , it creates free radicals that damage mitochondria in the liver cells and prevent them from using sufficient amounts of oxygen to produce energy .

其可能机制是小鼠骨髓间充质干细胞平均直径较大，多数细胞滞留于肺的微血管处死亡并在肝脏代谢。

The possible mechanism is that the average diameter of Bone marrow mesenchymal stem cells are large , most of them remain in the microvascular of pulmonary at death and metabolism in the liver . 2 .

酒精大部分由肝脏代谢（小部分在胃和口腔代谢），而人到了50岁的时候就会不一样。年纪越大，肝脏就会越大，但功能却越来越弱。

The majority of alcohol is metabolized by the liver , which changes when people hit their 50s . ( A small amount is metabolized in the stomach and mouth . ) The liver gets bigger as people get older , but the organ becomes less efficient .

结论：ASP具有调节肝脏药物代谢酶活性作用。

Conclusion : ASP can modulate the activities of drug metabolism enzymes .

改善肝脏脂肪代谢，减轻炎症状态可能有利于减轻IR。

Amelioration of lipometabolism in liver and mitigation of inflammation may help to reduce the extent of IR .

transT主要在肝脏内代谢，经肾脏消除。

Trans T is mainly metabolized in liver , and eliminated by kidney into urine .

细胞色素P450调节肝脏药物代谢的途径

The Pathway of Cytochrome P450 Regulating Drug Metabolism in Liver

医用黏合剂ZT胶延缓碘化油在肝脏内代谢实验研究

Experiment research of ZT glue postpone iodinated oil metabolism in liver

运用cDNA微阵列结合荧光半定量聚合酶链反应技术，首次大规模分析人胚发育过程中肝脏脂代谢相关基因的表达情况，比较孕早、晚期人胚肝脂代谢相关基因的表达谱。

Aim To analyze the expression profile of lipid metabolism related genes in human fetus liver by cDNA microarray and fluorescent semi quantitative PCR .

克伦特罗对大鼠肝脏氮代谢及IGF-I水平的影响

Effects of clenbuterol on the metabolism of nitrogen and IGF-I level in isolated perfused rat liver

EDF在肝脏中代谢。

EDF is metabolize in liver .

糖耐康含药血清具有改善高糖环境下肝脏糖脂代谢紊乱的作用，可能与增加肝细胞胰岛素敏感性改善IR有关。

TNK can improve the disorder of glucose and lipid metabolic in liver under the high glucose environment , which may be associated with increasing insulin sensitivity of hepatic . 3 .

漂白纸浆废水对鲫鱼（Carassiusauratus）肝脏微粒体代谢酶的影响

Effects of Bleached - Kraft Pulp Mill Effluent on Microsome Enzyme in Carp ( Carassius auratus ) Liver