组蛋白乙酰转移酶

组蛋白乙酰转移酶CBP/p300对人白细胞介素-5基因表达调控的影响及其分子机制研究

Influence of Histone Acetyltransferase CBP / p300 on Interleukin-5 Gene Expression Regulation and Its Molecular Mechanisms

组蛋白乙酰转移酶（HATs）通过对核心组蛋白进行乙酰化修饰来调节组蛋白的乙酰化水平，从而调控基因的转录，参与基因的表达，并由此介导基因的激活或沉默。

The level of histone acetylation is regulated by the histone acetyltransferase ( HATS ) with the acetylation modification of core histone . This further control gene transcription and gene expression regulation which resulted in gene activation or silence .

经RNA干涉试验，确定过氧化氢酶基因、髓鞘蛋白脂蛋白基因、组蛋白乙酰转移酶基因是外周血淋巴细胞中Clock基因下游的钟控基因。

Three of the 10 cDNA were identified as the clock-controlled genes ( CCG ), that is , the catalase , myelin proteolipid protein ( plp ) and histone acetylase gene .

人Elongator复合物及其组蛋白乙酰转移酶活性在基因表达调控中的功能研究

Roles of Human Elongator Complex and Its HAT Activity in Gene Regulation

此外，组蛋白乙酰转移酶的活性对HIV的增殖是必要的，至少一个科学小组建议组蛋白乙酰转移酶或相似的酶做为靶点也许是抑制病毒一个新方式。

In addition , HAT activity is necessary for the multiplication of HIV , leading at least one scientific group to suggest that targeting HATs or similar enzymes might be an new way to thwart the virus .

组蛋白乙酰转移酶（HAT）和组蛋白去乙酰化酶（HDAC）调节组蛋白乙酰化程度，HDAC在基因表达和染色体形成等方面起着重要的调节作用。

Histone acetyltransferases ( HATs ) and histone deacetylases ( HDACs ) are emerging as important components of protein complexes that affect the dynamics of chromatin folding during gene transcription .

组蛋白乙酰转移酶和去乙酰化酶以及液泡型H+-ATPase（V-ATPase）在昆虫生长发育过程中具有重要作用。

Histone acetyltransferases ( HATs ) and deacetylases ( HDACs ) as well as Vacuolar H + - ATPase ( V-ATPase ) play an important role in insect growth and development .

Elongator是真核生物中一个保守的组蛋白乙酰转移酶复合物，由六个亚基组成，被认为具有辅助转录延伸的功能。

The Elongator is a conserved protein complex , which consists of six subunits with the histone acetyl transferase activities in eukaryotes . The biological function of this protein complex was thought to facilitate transcriptional elongation .

本文主要就组蛋白乙酰转移酶调节基因转录以及组蛋白去乙酰化酶抑制剂促进记忆形成的作用机理进行综述。

In this paper , we reviewed the mechanisms on histone acetyltransferases regulating gene transcription and histone deacetylase inhibitors promoting memory formation .

研究重点是属于以组蛋白乙酰转移酶为代表的酶蛋白家族的p300/CBP。

The investigators focused on a protein called p300 / CBP that belongs to a family of enzymes known as histone acetyltransferases , or HATs .

目的：组蛋白乙酰基转移酶（HAT）和组蛋白去乙酰化酶（HDAC）的平衡共同调节着正常细胞的分化和代谢行为，而肿瘤的发生往往是二者的失衡所引起的。

Objection : The balance between histone acetyltransferase ( HATs ) and histone deacetylases ( HDACs ) regulates normal cell differentiation and metabolism activity .

本文讨论染色质动态调整的本质、组蛋白乙酰基转移酶和去乙酰基酶的作用、以及通过甲基化CpG结合蛋白而产生对染色质结构影响的机制等。

The nature of chromatin remodeling , the role of histone acetyltransferase and deacetylase , the repression mechanisms of chromatin induced by the methylated CpG binding proteins are discussed in this paper .

去甲基化和组蛋白去乙酰化转移酶抑制剂对K562细胞增殖和肿瘤相关基因表达的影响

Effect of Inhibitors for Demethylation and Histone Deacetylase on Proliferation of Cell Line K562 and Expression of Tumor Related Genes

去甲基化抑制剂和组蛋白去乙酰化转移酶抑制剂对前列腺癌细胞株雌激素受体的影响

Effects of DNA Demethylation and Histone Deacetylase Inhibition to Estrogen Receptor of Prostate Cancer Cell-Lines