磷酸肌醇

神经营养因子作用于Trk受体酪氨酸激酶后能激活细胞内磷酸肌醇3-激酶、细胞外信号调节激酶等信号通路，促进神经元的存活和分化。

Neurotrophic factor activates signal pathways of intracellular phosphoinositide 3-kinase and extracellular signal-regulated kinase after acting on Trk receptor tyrosine kinase . It promotes the survival and differentiation of neurons .

小牛血清去蛋白注射液的主要成分是小分子激活肽和磷酸肌醇寡糖，临床上用于治疗缺血性脑血管病。

Essential components of free protein serum of cow injection are micromolecule active peptide and phosphoinositide oligosaccharide .

嵌合受体失去与G蛋白偶联的能力，也不能产生磷酸肌醇水解。

But the chimeric receptor failed to couple to G-protein and subsequent stimulation of PI turnover .

T淋巴细胞内三磷酸肌醇传递conA诱导的增殖信号

Con A induced proliferative signal transduction mediated by ip_3 in T cells

三磷酸肌醇在IL-2诱导的T细胞增殖分化中的信息传递作用

Role of IP_3 in the signal-transduction of IL-2 & induced proliferation of human T Iymphocytes

吗啡长时程作用下小鼠脑组织磷酸肌醇含量和PKC活性的变化

Effects of chronic morphine treatment on inositol phosphates contents and PKC activity in mouse brain

本文简要介绍心肌细胞内皮素激活蛋白激酶C、丝裂原激活蛋白激酶、磷酸肌醇3'羟基激酶/蛋白激酶B等信号通路的调节作用。

This article briefly reviews the regulative effects of these signaling pathways including protein kinase C , mitogen activated protein kinase , and phosphoinositide 3 ' - OH kinase / protein kinase B.

磷酸肌醇钙信号系统和二酰基甘油蛋白激酶C信号系统可能与NE诱导心肌CFos和cMyc表达增强有关。

The signal transduction pathway of NE-induced c-fos and c-myc expressions may be associated with inositol phosphates-Ca 2 + system and diacylglycerol-protein kinase C system .

吗啡耐受依赖小鼠脑组织cAMP、cGMP及磷酸肌醇含量的变化：吗啡耐受依赖小鼠纹状体、海马、大脑皮层cAMP水平升高而相应部位cGMP含量明显下降，以纹状体、皮层变化最为显著。

Effect of morphine tolerance and dependence on cAMP , cGMP and inositol phosphates contents in the brain regions of mice .

先分别提取细胞内三磷酸肌醇（IP3）及环磷酸腺苷（cAMP），分别应用液体闪烁测量法、γ&闪烁记数仪测定其含量；

Intracellular 1 , 4 , 5-trisphosphate ( IP3 ) and cyclic adenosine monophosphate ( cAMP ) were extracted , their concentrations were measured by liquid scintillation technique and gamma scintillation counter respectively .

磷酸肌醇特异性磷脂酶C（PI-PLC）作为一种重要的酶，在真核生物多种信号传导途径中发挥重要作用。

Phosphatidylinositol-specific phospholipase C ( PI-PLC ) known as a critical enzyme plays an important role in various signal-transduction pathways in eukaryotic cells .

例如，科学家能够开发一种预防BAD被抑制的药物，或者他们用这些发现来检验当前设计来用于阻止其中一种分子如磷酸肌醇3-激酶发挥效应的药品。

For example , scientists could develop a drug to prevent BAD from being inhibited . Or , they could use the findings to test current drugs designed to block the effects of PI3K , one of the molecules .

细胞内贮存钙的释放主要由1，4，5－三磷酸肌醇（IP3）受体系统和ryanodine（暂译为兰尼定）受体系统调控。

The release of intracellular stored Ca2 + is mainly regulated by an inositol 1,4,5 triphosphate ( IP_3 ) receptor system and a ryanodine receptor system .

结论PTEN可能是一种重要的负性调节因子，调节三磷酸肌醇激酶（PI3Ks）/蛋白激酶B（Akt）所介导的信号传导通路，在胰岛素抵抗的发生、发展中起着重要的作用。

Conclusion PTEN might be a negative modulator of the PI3K-Akt pathway and then plays an important role in the development of insulin resistance .

钙库膜上的钙释放通道（ryanodine受体和三磷酸肌醇受体）受许多因素调控，其中之一就是新近研究得相当多的FK506结合蛋白。

The activities of calcium release channel on these calcium stores , ryanodine receptor and inositol trisphosphate receptor , are affected by several factors .

以对照和盐处理的拟南芥幼苗为材料，利用mRNA差异显示技术筛选得到一个受盐诱导的的3′端cDNA部分序列，其相应的基因AtITL1编码1,3,4三磷酸肌醇5/6激酶类似物。

By mRNA differential display from control versus NaCl_shocked Arabidopsis seedlings , we screened an Arabidopsis 3 ′ partial cDNA , which represents a gene encoding inositol 1,3,4_trisphosphate ( Ins ( 1,3,4 ) P 3 ) 5 / 6_kinase_like protein .

结果（1）心肌细胞膜上磷酸肌醇4激酶活性在心肌缺血后1h达到最高，为对照组的6.1倍，随着时间的延长，其活性逐渐下降，48h接近于正常水平；

Results The phosphatidylinositol 4-kinase activity reached its maximum in myocardium one hour after ischemia , being 6.1-folds higher than that of control and its activity declined with the lapse of time .

采用~3H-肌醇参入方法测定易卒中型自发性高血压（SHR~（SP））大鼠与WKY大鼠离体主动脉磷酸肌醇（IPs）的蓄积。

The accumulation of inositol phosphates ( IPs ) was measured by the method of 3H-inositol incorporation in aortae isolated from stroke prone spontaneously hypertensive ( SHRsp ) rats and WKY rats .

结论1,25（OH）2D3能刺激髁突软骨细胞内三磷酸肌醇受体（IP3R）钙释放通道开放，使细胞内钙离子水平显著升高；

Conclusion 1,25 ( OH ) - 2D-3 could stimulate the intracellular calcium release channel of inositol triphosphate ( IP3 ) receptor open in MCC in vitro and increases the level of intracellular calcium concentration .

目的：观察三磷酸肌醇（IP3）对大鼠逼尿肌肌条自发收缩频率及收缩幅度的作用。

Objective : To investigate the role of IP_3 on the range and frequency of the automatic contractility of isolated detrusor strip in rats .

PKC调节的1,4,5-三磷酸肌醇受体磷酸化在CCK-8S介导的胃窦平滑肌细胞钙动员中的作用

The role of PKC mediating the phosphorylation of type ⅲ inositol 1,4,5-triphosphate receptor in CCK-8 S induced calcium mobilization in gastric antral smooth muscle cells

目的：探讨顺铂诱导瘢痕细胞凋亡过程中细胞内游离Ca2+浓度和三磷酸肌醇（IP3）浓度的变化特点和意义。

Objective To study the change and significance of intracellular-free calcium levels and inositol 1,4,5-trisphosphate levels in the process of scar cell apoptosis induced by cisplatin .

方法：使用结合法测定三磷酸肌醇，根据Fura－2AM荧光变化测定钙离子浓度。

Methods : IP3 and calcium concentration were determined by the use of binding assay and from the change of Fura 2AM fluorescence , respectively .

最近的研究表明：G蛋白、cGMP、Ca2+和钙调素、三磷酸肌醇（IP3）及蛋白质磷酸酶（PP1和PP2A）都不同程度的参与了GA响应的信号传导过程。

Recent researches proved that G_protein , cGMP , Ca 2 + and CaM , IP 3 and protein phosphatases 1 and 2A were involved in the signal transduction pathways of GA response event .

目的研究灵芝多糖（GLB7）对小鼠T细胞三磷酸肌醇（IP3）和二酰基甘油（DAG）的作用，确定其对T细胞信号转导途径。

OBJECTIVE To investigate the effects of GLB 7 on inositol trisphosphate ( IP 3 ) and diacylglycerol ( DAG ) in murine T cell and to provide a scientific evidence for its immunomodulatory mechanism .

目的探讨CD28协同结核杆菌（M.tb）低分子多肽激活人外周血γδ+T细胞时，其胞内信号的传递经过磷酸肌醇3激酶（PI3K）的介导作用。

Objective To explore the role of phosphatidylinositol 3 kinase ( PI3K ) in the intracellular signaling transduction pathways of human peripheral blood γδ T cells activated by CD28 with Mycobacterium tuberculosis ( M.tb ) low molecular peptide antigen .

心肌缺血过程中磷酸肌醇4-激酶变化的研究

Study on changes in phosphatidylinositol 4-kinase activity during prolonged myocardial ischemia

用小麦麸皮植酸酶制备三磷酸肌醇的研究

Study on Producing Inositol Triphosphate Through the Phytase Extraction of Wheat Bran

固定化植酸酶及低磷酸肌醇的制备研究

Studies on the Preparation of Immobilized Phytase and Inositol Low-Phosphates

罗格列酮通过阻断磷酸肌醇-3激酶抑制醛固酮诱导的肾小球系膜细胞增殖的作用

Rosiglitazone Inhibited Aldosterone-Induced Mesangial Cell Proliferation via Blocking Phosphatidyl Inositol 3-Kinase Activation