生物学标志

目的：寻找视网膜母细胞瘤（retinoblastoma，RB）的生物学标志。

Objective : Our purpose was to define a biological marker of retinoblastoma ( RB ) .

OPN可能是肿瘤形成过程中的早期分子事件，可作为监测肿瘤恶性进展的一个生物学标志。

OPN expression may be an early molecular event in the process of tumorigenesis and could be used as a biological marker to monitor the malignant process of osteosarcoma .

结果：⑴在伤后1、6、24小时双肺生物学标志均出现明显的变化（P＜0.05～0.01）；

Results : ⑴ The significant changes of pulmonary biological markers appeared in both lungs at different time after trauma ( P ﹤ 0.05 ~ 0.01 ) .

而非侵入性检查的炎性生物学标志物可用于CAD的危险分级和实时病情监测，有相当高的临床应用价值。

However , non-invasive inflammatory biological markers can be used in risk stratification and disease monitoring of ACS , and have a high clinical value .

结果表明：P53基因蛋白产物的高表达在食管癌的发生中是一个早期生物学标志。

It is suggested that the overexpression of P53 protein may be an early event in carcinogenesis of the esophagus .

结论血清AGEs水平可作为北京地区30岁以上健康人群的年龄指征及DM人群初筛的生物学标志。

Conclusions Serum AGEs level might be age indication of healthy people over 30 years old and biomarker to screen diabetes patients .

目前临床上缺乏辅助AD早期诊断的特异性生物学标志，也没有有效的防治手段。我们主要在这两方面进行了研究。

There are no specific biomarkers for assisting the early diagnosis of AD and no efficient approaches for preventing or treating AD. The present study included two principal issues as follows .

血浆LEP水平则是反映人体内脂肪总最的生物学标志之一。

LEP can serve as a biomarker of total body fat mass .

研究背景及目的：血清胱抑素C（CysC）是近年来用于评估肾小球滤过率（GFR）的新型内源性生物学标志。

Background and Objectives Cystatin C ( CysC ) is a novel endogenous biomarker to estimate glomerular filtration rate ( GFR ) recently .

结论E-cadherin蛋白低表达与Snail蛋白高表达可能是胃黏膜恶性转变以及胃癌发生浸润转移的重要生物学标志。

Conclusions The decreased expression of E-cadherin and overexpression of Snail might be important biological markers for malignant transformation and invasion and metastasis of gastric carcinoma .

内皮祖细胞（endothelialprogenitorcells，EPCs）是一类具有异质性的内皮前体细胞群体，已被证明在血管新生过程中有重要作用，并被视为一种评价血管疾病危险因素的生物学标志。

Endothelial progenitor cells ( EPCs ) are heterogeneous precursor cell population of endothelial cells . EPCs are considered to play an important role in neovascularization and be as biomarkers to assess cardiovascular diseases risk .

探讨高血压对血管衰老生物学标志之一&晚期糖基化终末产物（AGEs）水平及其对血管组织结构的影响。

Objectives 1 . To explore the influence of hypertension on the advanced glycosylation end products ( AGEs ) which is looked as the signal of aging and it 's damage to the structure of the vascular tissue ;

目的探讨多种临床病理指标和生物学标志物在预测T1期膀胱移行细胞癌复发中的价值。

Objective To investigate the prognostic value of some clinicopathologic indexes and biologic tumor markers in predicting recurrence in T1 transitional cell carcinoma ( TCC ) of the bladder .

肠易激综合征（IBS）是一种常见的以腹痛／腹部不适伴排便习惯改变为特征的功能性肠病，缺乏形态学和生化学改变的生物学标志。

Irritable bowel syndrome is a common functional gastroenteropathy which is the characteristics of abdominal pain / abdominal discomfort and bowel evacuation habit , is short of change of morphology and biochemics .

结论：外周血淋巴细胞粘附分子CD44可作为早期诊断口腔颌面部恶性肿瘤、监测肿瘤复发和转移的一个生物学标志物。

Conclusion : The study suggest that CD44 with be used as an indicator in the diagnosis of oral and maxillofacial tumors , and for discovering recurrence and metastasis of tumors .

p53基因cDNA突变是大肠癌预后差的分子生物学标志物（P＜0.05）。p53基因蛋白产物受多种因素影响不能反映大肠癌的预后。

P53 cDNA mutation could provide poor prognostic information and was the molecular biomarker of poor survival of colon cancer ( P < 0.05 ), and P53 protein overexpression could not , and might be interfered by multiple factors existing in colon cancer .

[结论]MMP-2、TIMP-2是OSCC转移的重要生物学标志，MMP-2/TIMP-2比值对评估淋巴结转移的潜能有重要意义。

[ Conclusion ] MMP-2 and TIMP-2 are important biological marker reflecting metastasis of OSCC and MMP-2 / TIMP-2 may play an important role in evaluating lymph-node metastasis potential .

观察病理形态和ALI生物学标志，并测定肺组织中ICAM-1、NF-κB和抑制蛋白I-κBα的蛋白表达含量，以及氧化／抗氧化指标。

The expression of protein in lung tissues about ICAM-1 , NF - к B and I - к Ba ( the inhibitory protein of NF-KB ) as well as oxidative / antioxidative parameters in the homogenate of the rat lungs were determined .

本研究为PCNA、AgNORs、Bcl-2蛋白、Bax蛋白以及ras-p21蛋白等作为大肠癌人群化学预防研究的生物学标志物的可行性和有效性提供了依据。

The study provided evidence supporting that PCNA LI , AgNORs , Bcl 2 , Bax and ras p21 protein could be used as effective biomarkers for colorectal carcinogenesis in human chemopreventive trials .

方法采用免疫组化染色检测乳腺癌患者骨髓中肿瘤细胞的生物学标志及骨髓血浆的uPA活性。

Methods Immunocytochemical staining was used to study the biologic markers of disseminated tumor cells , and U-PA activity of the plasma in the bone marrow was assayed in breast cancer patients .

鸟氨酸脱羧酶（ODC）是多胺合成的关键酶，ODC活性的改变可作为反映脑胶质瘤恶性程度的可靠的生物学标志；

Ornithine decarboxylase ( ODC ) is the first metabolic key enzyme of polyamine metabolism , and the activity of ODC represent biochemical markers of malignancy in glioma .

MMP一2、MMP一9、TIMP一2、TIMP一1是OSCC转移的重要生物学标志，对它们的检测对评估淋巴结转移的潜能有重要意义。

MMP-2 MMP-9 , TIMP-2 and TIMP-1 are important makers for metastasis of OSCC , it may be useful for the evaluation of the potential ability of lymph-node metastasis of OSCC to detect these markers by immunohistochemistry .

目的：以锌卟啉（zpp）作为铅生物学标志物，探讨铅对儿童血红蛋白及智商的影响。

Objective : To explore the lead effect on haemoglobin ( Hb ), IQ of children in industrial area , using Zinc protorphyrin ( zpp ) as a biological effect remark of lead .

结论作为散发性CJD新的潜在生物学标志物H&FABP的检测结果有助于该病的生前诊断，进行血液筛查也能降低CJD通过输血进行医源性传播的危险性。

Conclusions The detection of H-FABP as a new potential biomarker of sporadic CJD could therefore be helpful for a pre-mortem diagnosis of the disease and applying a blood screening test may prevent the risk of iatrogenic transmission of CJD through blood transfusion .

生物学标志在产肠毒素性大肠埃希菌同源克隆鉴定中的应用

Application of Biomarkers in Homologous Clone Identification of Enterotoxigenic Escherichia Coli

三唑磷原药90天喂养大鼠生物学标志物的改变

Biomarker Changes on Rats after Feeding Raw Triazophos for 90 Days

因此，β-葡聚糖是与真菌感染相关的生物学标志物。

β - glucans are also biological markers of fungal infections .

生物学标志的概念与应用

The Concepts and Use of Biological Markers in Toxicology

实验目的：人类基因的异常改变是癌症发生发展的重要生物学标志之一。

Purpose : Genetic alteration is one of the biomarkers of human cancer .

人体衰老生物学标志的三维表示方法

Biomarker Expressed in Three dimension Method of Aging