灵芝孢子

灵芝孢子合剂的安全性毒理学及保健功能评价

Appraisement of Safety Toxicology and Health Protection Function of Ganoderma lucidum Spore Mixture

灵芝孢子粉胶囊急性毒性及遗传毒性实验研究

Study on acute toxicity and genetic toxicity test of Ganoderma Lucidum Spore Powder Capsule

超临界CO2萃取灵芝孢子油中三萜类化合物

Study on the effects of supercritical co_2 extraction of spores oil and triterpenoid compounds from Ganoderma

从灵芝孢子粉（sporesofGanodermaLucidum）中提取出水溶性粗多糖，经G。

Water-soluble crude polysaccharide has been extracted from spores of Ganoderma Lucidum .

GC-MS法测定灵芝孢子油中5种有机酸的含量

Quantification of five kinds of organic acids in Ganoderma Lucidum Spores Oil by GC-MS

灵芝孢子粉对NOD小鼠自发性涎腺炎的作用及机制

Intervention Effects of GLS on Sialoadenitis of NOD Mice

灵芝孢子多糖还可增强S180肉瘤荷瘤小鼠NK细胞的杀伤活性。

In addition , GLSPs could strengthen the activity of NK cells in S180 tumor-bearing mice .

灵芝孢子粉对癫痫大鼠海马区TNF-α、ET-1影响的研究

Effects of Ganoderma lucidum spores on TNF - α and ET-1 in the hippocampi of epilepsy rat

灵芝孢子粉对癫痫大鼠学习记忆、caspase-3和livin的影响

Effect of ganoderma lucidum spores powder on caspase-3 , livin and learning memory in epileptic rats

灵芝孢子粉对荷HAC肝癌小鼠抗肿瘤的实验性研究

Experimental Study on the Antitumor Effect of Ganoderma Lucidum

结论：灵芝孢子多糖可以提高荷艾氏腹水癌和S180肉瘤小鼠的免疫系统功能。

Conlusion : GLSPs could strengthen the immune system of the EC and S180 tumor-bearing mice .

GC定量分析结果表明：灵芝孢子油中检出9种已知脂肪酸，不饱和脂肪酸总量为73.6%；

Kinds of known fatty acids were quantitatively analyzed by GC , among them , nonsaturated fatty acids made up the majority ( 73.6 % ) .

采用中性蛋白酶对灵芝孢子粉进行水解提取灵芝孢子油，考察了酶解时pH值、温度、反应时间以及酶用量和终止酶解反应的pH值5个因素对油脂提取率的影响。

Spore oil was extracted by hydrolysis of neutral proteinase . During hydrolysis , pH , temperature , time of enzyme reaction and enzyme consumption , pH of terminating reaction were studied .

目的：研究灵芝孢子多糖对荷艾氏腹水癌（EC）和S180肉瘤小鼠的免疫调节作用。

Aim : To investigate the immunomodulatory effects of Ganoderma lucidum spores polysaccharides ( GLSPs ) on EC and S180 tumor-bearing mice .

结果破壁灵芝孢子油对雌雄小鼠经口半数致死量（LD50）均大于10g/kg体重，为实际无毒级物质；

Results The orally LD50 of broken cellwall lucid ganoderma spore is more than 10 g / kg ;

灵芝孢子对大鼠脊神经腹根切断后脊髓运动神经元存活及其NT-3、NOS表达的影响

Effects of ganoderma spore on survival and expression of NT-3 and NOS of spinal motor neuron following ventral root cut in the rat

本文提出了一种测定灵芝孢子油中总三萜含量的可靠方法，即薄层色谱（TLC）-光度法。

In this paper a simple and reliable method to determine the content of triterpenoids in ganoderma spore lipids by the thin-layer chromatography ( TLC ) - spectrophotometry was produced .

灵芝孢子油对MPTP处理小鼠行为学及黑质区病理变化的影响

Effect of the oil from ganoderma lucidum spores on pathological changes in the substantia nigra and behaviors of MPTP-treated mice

120只SPF级昆明种雌性小鼠平均分成3组，菌草灵芝孢子粉分三个剂量组给小鼠灌胃，共30d。

120 mice were randomized into 3 groups : three groups of grass-cultivated Ganoderma lucidum spores powder through gastric tube for 30 days .

灵芝孢子油加深海鱼油组的小鼠大脑海马NOS阳性神经元与其它组的小鼠比较有显著性增加。

Compare with other groups of mice , NOS positive neurons of cerebral hippocampus enhanced significantly in the combination of ganoderma spore oil and deep sea fish oil group of mice .

灵芝孢子粉能够抑制痫性放电，使脑电图痫波发放减少和波幅降低，并通过抑制IL-10的神经元表达而发挥免疫调节作用。

Ganoderma spore powder can suppress epileptic discharge , reduce the amplitude of EEG epilepsy wave of and lower paid , inhibit IL-10 expression in neurons to regulate immune .

镜下观察，灵芝孢子粉组与空白对照组相比，肿瘤坏死组织较多，细胞异型性较小。灵芝孢子粉组VEGF、MVD表达水平较空白对照组有明显下降。

Morphologic study showed there were more necrosis and less degree of atypia , decreased MVD and VEGF expression in the LGS group , as compared with that in the blank control group .

目的：观察和探讨灵芝孢子粉对戊四氮（PTZ）致痫大鼠海马区肿瘤坏死因子-α（TNF-α）、内皮素-1（ET-1）含量变化的影响。

Objective : To observe and explore the influence of Ganoderma lucidum spores on the TNF - α and ET-1 content in the hippocampus of rat with epilepsy caused by Pentetrazole ( PTZ ) .

结果在Morris水迷宫检测中，灵芝孢子油组、深海鱼油组和灵芝孢子油加深海鱼油组小鼠的逃逸潜伏期明显缩短。

Results The escape latency obviously shortened on the test of Morris water maze in the ganoderma spore oil group , deep sea fish oil group , combination of ganoderma spore oil and deep sea fish oil group of mice .

灵芝孢子粉多糖Lzps-1的化学研究及其总多糖的抗肿瘤活性

Chemistry of polysaccharide Lzps-1 from Ganoderma lucidum spore and anti-tumor activity of its total polysaccharides

在Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验中均呈阴性反应，未显示有遗传毒性作用，表明灵芝孢子粉胶囊基本无毒性。

Ames test , Micronucleus test of bone marrow cell in mice and sperm shape abnormality test in mice appear negative reaction and a lack of toxic effect , indicating that Ganoderma Lucidum Spore Powder Capsule is non-toxicity .

破壁灵芝孢子粉多糖的GPC有两个多糖峰，相对分子质量分别为7.80×104和1.17×104，而不破壁灵芝孢子粉多糖只有相对分子质量为7.80×104的一个峰。

The polysaccharide of unbroken spore has only one GPC peak , its MW was 7.80 × 104 , and the broken one has two GPC peaks , their MW were 7.8 × 104 , and 1.17 × 104 , respectively .

用药组经灌胃给予灵芝孢子粉（灌胃前禁食6h），灌胃体积为1.0ml/次；模型组和正常组经灌胃给予同体积生理盐水。

The treatment group was given medication spores powder ( fasting 6 h before gavage ), by gavage volume of 1.0 ml / time ; model group and the normal group was given the same volume of normal saline .

方法对单侧坐骨神经切断再吻合后的大鼠ig给予萌动激活灵芝孢子，通过电生理、荧光金（FG）逆行标记和组织学等方法观察受损伤运动神经元轴突再生情况。

Methods Rat was ig administered by GASP after the sciatic nerve was cut and anastomosed unilaterally and the axonal regeneration of injured motor neuron was observed by electrophysiology , Fluorogold ( FG ) retrograde labeling , and histologic techniques .

探讨全破壁灵芝孢子治疗中老年男性部分雄激素缺乏症（PADAM）的疗效。

[ Objective ] To investigate the effect of sporoderm-broken spores of Ganoderma Lucidum in the treatment of partial androgen deficiency of the aging male ( PADAM ) .