激肽

目的探讨急性和慢性呼吸道炎症过程中激肽的生成途径和机制。

Objective To investigate the kinin generation pathways in acute and chronic airway inflammation .

急性和慢性呼吸道炎症疾病激肽形成机制探讨

Kinin generation in acute and chronic airway inflammation

血液稀释治疗对急性脑梗塞血浆激肽释放酶原、蛋白C和蛋白S含量的影响

Effect of Hemodilution on Plasma Prekallikrein , Protein C and Protein S in Patients with Acute Ischemic Stroke

速激肽受体拮抗剂对白三烯C4诱导豚鼠气道收缩和微血管渗漏的作用

Effects of tachykinin receptor antagonists on leukotriene C 4 induced bronchoconstriction and airway microvascular leakage in guinea pigs 1

方法：（1）利用基因重组（geneticrecombination）制备人组织激肽释放酶。

In the present study : ( 1 ) We used the genetic recombination method to produce kallikrein .

P物质属于速激肽家族成员，在哺乳动物神经系统中可能作为一种神经递质或调质。

Substance P ( SP ), belong to the tachykinin neuropeptide-family likely to function as a neurotransmitter and / or neuromodulator in the mammalian nervous system .

方法使用RTPCR的方法扩增人胰腺组织cDNA，从中扩增出激肽原酶基因。

METHODS The kininogenase gene was amplified from human pancreas cDNA synthesized by RT PCR .

提示NGF与速激肽的产生有直接关系。

It prompts that NGF has the direct relationship to produce tachykinin .

近期的研究表明，内皮素、P物质前体分子-前体速激肽及黑皮素等三种非阿片小肽与吗啡镇痛和耐受密切相关。

Recent research indicated that three small non-opiate peptides such as endothelin , the precursor of substance P-protachykinin , melanocortin have been presumed to be involved in morphine tolerance .

多发性硬化症患者单核细胞激肽B1受体的表达：T2加权MRI所示病灶体积和临床残疾相关性的研究

Kinin B_1 receptor expression on multiple sclerosis mononuclear cells : Correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability

5―HT的输注不能引起类癌性潮红，相反，舒缓激肽的注入则可得到较近似的阳性结果。

Carcinoid flush cannot be reproduced by 5-HT infusion though bradykinin injection will produce a tolerably close imitation .

在介导这一炎症特别是神经源性炎症过程的炎性介质中，缓激肽、P物质、速激肽在哮喘的发病机理中起重要作用。

Among the mediators implicated in the genesis of this inflammatory process , bradykinin > tachykinin and substance P are considered to play important roles in the pathogenesis of asthma , especially in neurogenic inflammation .

激肽原1可以在所有的PVR患者玻璃体和血清样本中检测到（24/24100%）。

Kininogen 1 could be detected in 100 % of vitreous and serum samples .

血管舒缓激肽促进剂的QSAR研究

The QSAR research of bradykinin-potentiating pentapeptides

方法提取人胰腺组织总RNA，逆转录后PCR扩增激肽释放酶cDNA。回收、补平后插入质粒KS，构建出中间载体KSKK，酶切鉴定后双向测序分析激肽释放酶基因序列。

[ Methods ] Total RNA was extracted from human pancreas and then human tissue kallikrein gene cDNA was amplified by reverse-transcription PCR and cloned to the KS plasmid .

胰激肽原酶（pancreatickininogenase）是一种催化大分子前体物释放生物活性肽的酶。

Pancreatic kininogenase ( PK ) is an enzyme which can serve as a catalyst to help macromolecular precursors release bioactive peptide .

激肽释放酶&激肽系统基因相关SNPs及其单体型与长沙汉族人群脑出血的关系研究

The Study of the Association of SNPs and Haplotype of Genes Involved in the Kallikrein-kinin System with Cerebral Hemorrhage in Changsha Han Chinese

将编码人组织激肽释放酶成熟蛋白的基因片段扩增并分别克隆到原核表达载体pET28（b）及分泌型表达载体pET20（b）中，使其C端融合6×Histag序列。

Human tissue kallikrein gene fragment encoding mature kallikrein was amplified and cloned into pET 28 ( b ) and pET 20 ( b ) plasmid with C terminal 6 × His Tag .

目的：观察实验性脑缺血再灌注损伤后不同时期组织型激肽释放酶活性、缓激肽含量、缓激肽B1、B2受体的动态表达情况，并探讨其在脑缺血病理生理过程中的作用。

Aim : To observe the concentration of bradykinin , the expression of B1 and B2 bradykinin receptors at different time points after cerebral ischemia and reperfusion .

人腺体激肽释放酶基因重组表达载体pPICZαChK2的构建

Construction of recombinant human glandular kallikrein expression vector pPICZ α ChK2

本文主要就激肽释放酶激肽系统（KKS）在心血管领域的研究进展进行综述。

This paper is to review the researches on the kallikrein kinin system in cardiovascular system .

生物体内的许多系统都与血压形成有关，而肾素-血管紧张素系统（RAS）和激肽-激肽释放酶系统（KKS）是两个重要的血压调节控制系统。

In organism many systems affect the blood pressure in which renin-angiotensin system and bradykinin-Kallikrein system are two important modulators for blood pressure control system .

克隆人胰腺组织激肽释放酶基因（hKK），构建融合荧光蛋白基因的真核表达载体，在CHO细胞中表达，为开发激肽释放酶基因工程产品以及开展基因治疗高血压研究奠定了基础。

Molecular cloning and expression of human tissue kallikrein gene fused with EGFP report gene in CHO cells for the development of human kallikrein products and further study in gene therapy .

目的：观察怡开（胰激肽原酶肠溶片）对2型糖尿病（T2DM）早期肾病的疗效。

Objective : To study the curative effect of YiKai ( pancreatic kininogenase tablets ) in the treatment of early diabetic nephropathy of type 2 diabetes .

方法用比色法测定激肽释放酶（TKA）活性，用HOE140和胰激肽释放酶改变激肽系统的功能。

Methods The TKA activation was measured and the function of kinin-system was changed by the antagonist of bradykinin B2 receptor-HOE 140 and kallikrein .

我们研究了胸腺激肽与胸腺细胞的温育时间、不同剂量及酸、碱、热和酶处理后的胸腺激肽对PNA受体的影响。

The effect of thymic peptide hormone on the changes of PNA receptors on the cell surface of mouse thymocyte was found to be both concentration and time dependent .

血管紧张素Ⅰ转换酶（ACE）在血压调节中起着重要的作用，它可以促进血管紧张素Ⅱ的形成和舒缓激肽的降解，引起血压升高。

Angiotensin ⅰ - converting enzyme ( ACE ) plays a pivotal role in the regulation of blood pressure . It increases blood pressure by promoting the generation of angiotensin II and the degradation of bradykinin .

内源性凝血途径的起始部分称为接触系统，包括高分子量激肽原、前激肽释放酶、XII因子和XI因子。

Contact system is the beginning of intrinsic coagulation pathway and comprises four components : high molecular weight kininogen , prekallikrein , factor XII ( FXII ) and factor XI ( FXI ) .

缓激肽是血浆激肽释放酶&激肽系统的基本组成部分，具有缓激肽B1和缓激肽B2两种受体，其中缓激肽B2受体在糖尿病肾病的发生、发展中起着重要作用。

Bradykinin is an essential component of kallikrein kinin system , which have two receptors : bradykinin B1 receptor and bradykinin B2 receptor . The latter receptor plays an important role in diabetic nephropathy .

浙江蝮蛇（Agkistrodonhalyspallas）蛇毒中舒缓激肽增强肽的研究&Ⅱ.舒缓激肽增强肽组分Ⅰ结构与功能的关系

Studies on the bradykinin potentiating peptide ( bpp ) from the venom of the Zhejiang pit viper ( agkistrodon halys pallas ) & ⅱ . relationship between structure and function of bpp_1