激肽原

目的：通过观察结构上改变的体外连接蛋白（aVN）底物上激活的高分子激肽原（HKa）对细胞伸展的影响，比较VN与aVN上HKa对细胞抑制活性。

Objective : This paper was designed to analyze the effects of kinin free high molecular weight kininogen ( HKa ) on cell spreading to altered vitronectin ( aVN ) .

激肽原1可以在所有的PVR患者玻璃体和血清样本中检测到（24/24100%）。

Kininogen 1 could be detected in 100 % of vitreous and serum samples .

方法使用RTPCR的方法扩增人胰腺组织cDNA，从中扩增出激肽原酶基因。

METHODS The kininogenase gene was amplified from human pancreas cDNA synthesized by RT PCR .

胰激肽原酶（pancreatickininogenase）是一种催化大分子前体物释放生物活性肽的酶。

Pancreatic kininogenase ( PK ) is an enzyme which can serve as a catalyst to help macromolecular precursors release bioactive peptide .

目的：观察怡开（胰激肽原酶肠溶片）对2型糖尿病（T2DM）早期肾病的疗效。

Objective : To study the curative effect of YiKai ( pancreatic kininogenase tablets ) in the treatment of early diabetic nephropathy of type 2 diabetes .

内源性凝血途径的起始部分称为接触系统，包括高分子量激肽原、前激肽释放酶、XII因子和XI因子。

Contact system is the beginning of intrinsic coagulation pathway and comprises four components : high molecular weight kininogen , prekallikrein , factor XII ( FXII ) and factor XI ( FXI ) .

在PVR特异的蛋白质中，激肽原1是鉴定到的肽段数较多大的相对高丰度蛋白质；而IGFBP-6与增殖的信号转导有关。

Among the PVR special proteins , kininogen 1 was one of the relatively high abundance proteins of which more peptides could be identified ; IGFBP-6 was involved in signal transduction .

研究发现：激肽原分布于L4～L6脊神经节及腰骶髓灰质的第Ⅱ，Ⅲ，Ⅳ，Ⅸ层神经元及脊髓白质的神经胶质细胞和神经纤维。

The study has indicated that kininogens exist in the neurons of dorsal ganglion and gray matter layers ⅱ,ⅲ,ⅳ,ⅸ of the spinal cord , as well as exist in the nerve fibers and the neurogliocytes of white matter .

目的：体外实验研究活化型高分子量激肽原（HKa）轻链富含组氨酸区域5（HKD5）对人脐静脉内皮细胞（HUVECs）的粘附、游走及血管形成的影响。

AIM : To study the effect of domain 5 of the active high molecular weight kininogen ( HKa ) on the vitronectin-mediated adhesion and migration and angiogenesis of human umbilical vein endothelial cells ( HUVECs ) in vitro .

莫沙比利联合胰激肽原酶治疗糖尿病胃轻瘫疗效观察

Combined Treatment of Diabetic Gastro Paresis with Pancreatic Kininogenase and Mosapride

激肽原1作为增生性玻璃体视网膜病变血清分子标志物的验证

Verification of kininogen 1 as a serum molecular marker of proliferative vitreoretinopathy

目的考察胰激肽原酶的大鼠结肠吸收。

AIM The colon absorption of pancreatic kininogenase was investigated .

激肽原基因的选择性剪接与功能研究进展

Progress in the Study on Alternative Splicing and Functions of Kininogen Genes

胰激肽原酶治疗78例糖尿病性肾病临床观察

Clinical observation of pancreatic kininogenase for treating 78 cases of diabetic nephropathy

目的：制备胰激肽原酶油相制剂并对其稳定性进行考察。

The potency of the oil formulation was assayed by ultraviolet spectrophotometry .

胰激肽原酶治疗老年糖尿病肾病的临床研究

Clinical Research on Senile Diabetic Nephropathy Treated with Kallidinogenase

毕赤酵母表达重组人胰激肽原酶

Recombinant Human Pancreatic Kallikrein Expressed in Yeast Pichia Pastoris

目的提高胰激肽原酶的纯度。

Objective To improve the purity of pancreatic kininogenase .

活化型高分子量激肽原潜在的抗肿瘤作用及其分子机制

Potential Anti-tumor Function of Cleaved High Molecular Weight Kininogen and Its Molecular Mechanism

目的：研究胰激肽原酶对老年糖尿病肾病的影响。

OBJECTIVE : To study the effect of kallidinogenase on senile diabetic nephropathy .

离子交换色谱法制备高纯度胰激肽原酶

Preparation of high purity pancreatic kininogenase by ion-exchange chromatography

胰激肽原酶对大鼠微血管内血栓形成预防作用的研究

Study of the Preventive Effect of Pancreatic Kallidinogenase on Microvascular Thrombosis in Rats

大鼠结肠吸收胰激肽原酶的研究

Absorption of Pancreatic Kininogenase from the Perfused Rat Colon

蛇毒激肽原酶对大鼠脑缺血再灌注的作用及机制

Effect and mechanism of kallikrein from agkistrodon acutus venom to the cerebral ischemia-reperfusion rats

另外，此酶能够水解牛低分子量的激肽原，释放舒缓激肽。

Moreover , the enzyme hydrolyzed bovine low molecular mass kininogen and releasing bradykinin .

胰激肽原酶肠溶片对早期糖尿病肾病36例疗效观察

Clinical Efficacy of Pancreatic Kininogenase Enteric-coated Tablets on 36 Cases of Early Diabetic Nephropathy

人尿激肽原酶对急性脑梗死侧枝循环的影响

Effects of Human Urinary Kallidinogenase on Collateral Circulation in Patients with Acute Cerebral Infarction

激肽原基因在不同物种中有一定的差异，其编码的蛋白质产物也有所不同。

The kininogen gene and its coded proteins are slightly different in various species .

人胰激肽原酶的表达塞来昔布对胰腺癌的放疗增敏作用及其机制研究

Study on expression of human pancreatic kininogenase Radiosensitizing effect of celecoxib on human pancreatic carcinoma

人胰激肽原酶的表达

Study on expression of human pancreatic kininogenase