浸润癌

结论LEEP刀对宫颈疾病是一种非常理想的治疗方法，并有效阻断癌前病变发展为浸润癌。

ConclusionLEEP electrotome is a very ideal therapy of cervical disease and can block the development of precancerosis to infiltrating carcinoma effectively .

术后辅助治疗5例，均为宫颈浸润癌术后辅助放疗和/或化疗，分别于术后6～18个月出现更年期症状，术后未辅助治疗5例，其中1例出现更年期症状。

Five patients with auxiliary treatment after operation , auxiliary radiotherapy and / or chemotherapy after cervical infiltrating carcinoma operation and occur climacteric symptom . Five patients without auxiliary treatment after operation , one of five patients occurs climacteric symptom .

方法：收集子宫颈浸润癌Ⅰb～Ⅲ期患者30例，术前常规行盆腔介入治疗。

Methods : Thirty patients with invasive cervical cancer stage ⅰ b ~ⅲ were included .

P-选择素的表达率在原位癌、微小浸润癌和浸润癌中无显著差别（P0.05）；

There was no difference in P-selectin among carcinoma in situ , microinvasive carcinoma and invasive carcinoma ( P0.05 );

宫颈浸润癌组织中CD44V6、PCNA、CⅣ表达与转移潜能的关系研究

Expression of CD44V6 、 PCNA 、 C ⅳ in Cervical Invasion Cancer and Metastasis Potentiality

乳腺浸润癌的微血管数在癌转移中的意义用FⅧ相关抗原免疫组化染色定量观察48例乳腺浸润癌。

Microvessel quantitation in 48 patients with invasive breast carcinoma was analyzed by immunohistochemistry using antibody to factor ⅷ - related antigen .

DC三参数均联合表达者在管内癌组和浸润癌组最高（分别为33.33%、55.22%），并且这两组病例无DC三参数均阴性表达病例。

Combined expression rates of three parameters labeling DC were the highest in DCIS group ( 33.33 % ) and IDC group ( 55.22 % ) .

儿黄散通过对PCNA、EGFR和bcl-2的调控，抑制细胞增殖，促进细胞凋亡，使宫颈癌前病变细胞向良性转化，从而达到阻断宫颈浸润癌发生的目的。

By controlling PCNA 、 EGFR and bcl-2 , EHS resist proliferation and promote apoptosis , which make it can prevent occurrence of canceration in cervix .

术后为早期浸润癌和高级别的CIN、切缘阳性者，应根据具体情况进一步处理。

Cases with microinvasive carcinoma or high grade CIN after conization , with positive margin could be given further treatment .

宫颈外观的糜烂包括轻、中、重度宫颈糜烂、CIN、甚至早期宫颈浸润癌。

Cervical erosion include mild , moderate , severe degree , CIN , and early stage of cervical invasive carcinoma .

目的：探讨凋亡抑制基因Bcl-2和增殖细胞核抗原（PCNA）在乳腺导管浸润癌中的表达及与各临床参数的关系。

Objective : To examine the expressions of apoptosis suppressor gene Bcl 2 and proliferating cell nuclear antigen ( PCNA ) in invasive ductal carcinoma of breast and their clinical significance .

结果宫颈原位癌与浸润癌SCC阳性率分别为5.6%和46.9%。

Results Increased levels of SCC were found in 5.6 % and 46.9 % of the patients with carcinoma in situ and invasive carcinoma of the uterine cervix respectively .

结论：应用LEEP诊治CIN效果可靠，并可用于宫颈微小浸润癌的诊断。

Conclusion Application of LEEP is effective and reliable in CIN diagnosis and treatment , which is also applicable to diagnosis of cervical microinvasive carcinoma .

不同病变之间的HPV16病毒载量不完全相等，浸润癌组低于HSIL组。

The viral load was different among groups , which was higher in cancer group than that in HSIL group . ( 3 ) .

结果：1.HPV6/11只见于CINⅠ和CINⅡ，而HPV16/18是感染CINⅢ和浸润癌中主要类型。

Results : ( 1 ) HPV 6 / 11 was only detected in CIN I and II , whereas HPV l6 / 18 are dominant types in CIN III and invasive cancer .

结果（1）与慢性宫颈炎相比，CINⅡ级、CINⅢ级、浸润癌HPV16、18杂交信号阳性率显著增高（P<0.01）；

Results ( 1 ) The positive rate of HPV hybrid signals in CIN ⅱ, CIN ⅲ and SCC were all significantly higher than in chronic cervicitis ( P < 0.01 ) .

近期研究证实，MBT和它伴同的上皮内癌及微浸润癌在排除了腹膜假黏液瘤和转移癌后，预后良好。

Recent researches prove that MBT , MBT with intraepithelial carcinoma and MBT with microinvasion have well prognosis when pseudomyxoma peritonei ( PMP ) and ovarian metastatic carcinoma are removed .

结果：研究发现各期中Langerhans细胞的数量不同，不典型增生中最少（P<0.05），早期浸润癌数量明显增多（P<0.05）。

Results : The number of Langerhans cells in atypical hyperplasia was decreased ( P < 0.05 ), but the number of langerhans cell in carcinoma in site was increased ( P < 0.05 ) .

结果正常宫颈、宫颈上皮内瘤变、宫颈原位癌、宫颈浸润癌组织中HIF-1α的阳性表达率分别为0%、12.5%、43.5%、81.4%。

Results The expression rates of HIF-1 α protein were 0 % , 12.5 % , 43.5 % , 81.4 % respectively in normal cervical tissue , CIN , cervical carcinoma in situ and invasive carcinoma of cervix uteri .

目的研究环氧化酶2（COX2）在乳腺浸润癌中的表达情况及其与乳腺癌临床病理特征的关系。

Objective To study the expression of cyclooxygenase - 2 ( COX-2 ) in breast invasive carcinoma and its clinicopathologic significance .

结果：筛查并经病理诊断为HPV感染365例，宫颈上皮内瘤变（CIN）Ⅰ级71例，CINⅡ48例，CINⅢ55例，宫颈浸润癌31例。

Results : Final pathological diagnosis was HPV infection in 365 cases , cervical intraepithelial neoplasia ( CIN )ⅰ in 71 cases , CIN ⅱ in 48 cases , CIN ⅲ in 55 cases , invasive cervical cancer 31 cases .

结果：从正常宫颈上皮到原位癌再到浸润癌，Survivin、CD44v6、MMP-2阳性表达量显著升高（P<0.05）。

Results : It was found that the positive level of survivin , CD_ ( 44v6 ) and MMP-2 expression followed this increasing order : normal cervical epithelium → cervical carcinoma in situ → invasive carcinoma of cervix ( P < 0.05 ) .

结果宫颈炎性病变占宫颈病变88.27%，宫颈损伤及良性肿瘤等病变占1.79%，宫颈上皮内瘤样病变（CIN）占8.98%，宫颈浸润癌占0.96%。

( Results ) Of all the cervix disease cases , the percentage of the inflammation diseases was 88.27 % , injury and benign tumor , 1.79 % , cervical intraepithelial neoplasia ( CIN ), 8.98 % , and invasive carcinoma , 0.96 % .

子宫颈炎的HPV-DNA含量为414±38，子宫颈癌前病变及浸润癌的HPV-DNA含量为418±32，两者比较无显著性差异（P>0.05）。

The HPV-DNA amount of cervicitis was 414 ± 38 and that of cervical precancerous lesion and infiltrate cancer was 418 ± 32.The parallel difference between the two was not notable ( P > 0.05 ) .

宫颈锥切术后，因发现早期浸润癌，行广泛子宫切除术者2例（37%）；因CINⅢ级（CINⅢ）或微小浸润癌行全子宫切除术者13例（241%）。

After conization radical hysterectomy was performed in 2 cases ( 3 7 % ) because of early invasive carcinoma and simple hysterectomy was performed in 13 cases ( 24 1 % ) because of CIN ⅲ involved the gland and microinvasive carcinoma of the cervix .

ICAM-1、E-cadherin在原位癌中的阳性表达率均显著高于微小浸润癌（P<0.05），微小浸润癌中的阳性表达率均显著高于浸润癌（P<0.05）。

Both the expression ratio of ICAM-1 and E-cadherin in carcinoma in situ were higher than that of microinvasive carcinoma ( P < 0.05 ), and the expression ratio of ICAM-1 and E-cadherin in microinvasive carcinoma were both higher than that of invasive carcinoma ( P < 0.05 ) .

中、重度异型增生上皮细胞核DI及超过2.5c细胞的百分数处于单纯增生+轻度异型增生与浸润癌之间，3组DI及超过2.5c细胞的百分数差异显著。

The DI and percentage exceeding 2.5c of moderate + severe dysplasias were in between those of simply hyperplastic + midly dysplastic lessions and invasive carcinomas , the differences of DI and percentage exceeding 2.5c among the 3 groups were significant .

根据细胞与病理学诊断有无宫颈病变及其病变程度分组。①宫颈癌与高度鳞状上皮内瘤变（HSIL）组：包括宫颈浸润癌9例、CINⅢ57例、CINⅡ53例；

According to the cytological and pathological diagnosis , the patients were divided into three groups : ① cervical cancer and high-grade squamous intraepithelial lesions ( HSIL ) group , including 9 cases of invasive cervical cancer , 57 CIN ⅲ and 53 CIN ⅱ;

结果COX2在乳腺浸润癌中的阳性表达率为73.5%（61/83），显著高于癌旁组织（P<0.001）；

Results The positive rate of COX-2 in breast invasive carcinoma was 73.5 % ( 61 / 83 ), which was significantly higher than those in non-cancerous specimens ( P < 0.001 ) .

青年妇女宫颈浸润癌77例临床分析

Cervical carcinoma of young women : Clinical analysis of 77 cases