泰利霉素

简要介绍大环内酯类抗生素发展近况，讨论了大环内酯类抗生素的作用机制、耐药机制、构效关系及泰利霉素（Telithromycin）和ABT-773（Cethromycin，喹红霉素）的药理、临床性质。

The Development of Macrolide Antibiotics was introduced briefly and the action mechanism , structure-activity relationships , and resistant mechanisms of the macrolides were discussed . The pharmacological and clinical characteristics of Telithromycin and ABT-733 ( Cethromycin ) were reviewed as well .

酮内酯中最具代表性的药物泰利霉素已于2001年成功上市，其对包括大环内酯耐药菌在内的革兰氏阳性菌具有良好的抗菌活性。

Telithromycin , which is the representative of ketolides , has come into market in 2001 . It shows very good activity against some macrolide-resistant bacteria .

目的合成制备泰利霉素的关键中间体。

OBJECTIVE Studies on the synthesis of the key intermediate of Telithromyin .

以克拉霉素为原料，经多步反应制得酮内酯类抗生素泰利霉素。

A new process for preparation the ketolide antibiotic telithromycin by multistep reactions started from clarithromycin is reported .