沙星

司氟沙星CHL细胞体外染色体畸变试验

Effects of sparfloxacin on chromosome aberration of CHL cell in vitro

方法：对56例细菌性泌尿道感染患者予司氟沙星100～200mg·d-1，po，疗程7～14d。

METHODS : Fifty six patients with urinary tract bacterial infections were treated with oral sparfloxacin in dose of 100-200 mg · d - 1 for 7-14 d.

光谱法研究普利沙星与小牛胸腺DNA的结合作用

Spectroscopic Studies on the Binding of Prulifloxacin and ct-DNA

pH在4.0～5.5之间的葡萄糖酸依诺沙星溶液稳定性较好。

When the pH value was at 4.0 ~ 5.5 enoxacin gluconate solution was stable .

HPLC柱切换法测定人血浆及尿中洛美沙星浓度

Determination of lomefloxacin in human plasma and urine by HPLC column switching technique

耐诺氟沙星的细菌的R质粒接合试验的阳性率为51.2%。

The positive rate of the R plasmid conjugation experiment was 51.2 % in norfloxacin resistant strains .

目的：用HPLC法测定甲磺酸培氟沙星胶囊的含量。

Objective : To establish a HPLC method for the determination of pefloxacin mesylate capsules .

盐酸洛美沙星及其胶囊的HPLC测定

HPLC determination of Lomefloxacin and its capsules

表明单诺沙星对DNA旋转酶的抑制是PAE产生的机制之一。

The results indicated that the danofloxacin inhibited the DNA gyrase mainly .

方法利片J荧光光谱研究巴罗沙星与DNA的作用强度并计算热力学数据ΔH；

Methods Fluorescent spectroscopy was used to study the interaction of balofloxacin with DNA and to calculate the thermodynamic constants .

实验结果表明，铜（Ⅱ）和DNA均能与洛美沙星作用而猝灭洛美沙星分子的内源性荧光。

The results show that the fluorescence intensity of LMX can be quenched in the presence of Cu (ⅱ) or DNA in LMX system .

目的：建立洛美沙星人血浆及尿药浓度HPLC柱切换测定法。

OBJECTIVE : To establish a simple HPLC column switching method for measuring lomefloxacin in human plasma and urine .

RP-HPLC内标法测定甲苯磺酸托氟沙星原料及其胶囊的含量

Determination of Tosufloxacin Tosilate and its Capsules by RP-HPLC

大鼠血浆中克林沙星的RP-HPLC测定

Determination of Clinafloxacin in Plasma of Rats by RP-HPLC

目的建立RP-HPLC法测定盐酸洛美沙星及其制剂的含量。

OBJECTIVE RP-HPLC method was established to determine the Lomefloxacin and its preparations .

结论巴罗沙星以沟槽键合方式与DNA相瓦作用；Mg~（2+）对巴罗沙星与DNA的结合有中介作用。

Conclusion Balofloxacin interacted with CT-DNA in the mode of groove binding and Mg ~ ( 2 + ) could mediate the binding of balofloxacin to DNA .

RP-HPLC法测定天门冬氨酸洛美沙星注射液的含量

Determination of lomefloxacin aspartate injection by RP-HPLC

选用Wistar大鼠和昆明系小鼠对马波沙星的遗传毒性进行研究。

Wistar rat and closed Kunming strain mice were selected to study the genetic toxicity of marbofloxacin .

红霉素及左氧沙星单用和联合时抗解脲脲原体MIC的影响

In vitro effect of erythromycin and levofloxacin alone or in combination against ureaplasma urealyticum

RP-HPLC同时测定中华绒螯蟹肝脏中诺氟沙星、环丙沙星和恩诺沙星残留

Simultaneous determination of norfloxacin , ciprofloxacin and enrofloxacin residues in liver of Eriocheir sinensis by RP-HPLC

采用HPLC法测定血中恩诺沙星及其代谢产物环丙沙星的浓度，用统计矩原理处理药物浓度时间数据。

Concentrations of enrofloxacin and its metabolite ciprofloxacin in plasma were determined by HPLC and the concentration-time data were analyzed by statistical moment principle .

目的：建立普卢利沙星的RP-HPLC含量测定及有关物质检测方法。

Objiective : To establish a RP-HPLC method for the determination of prulifloxacin and its relevant substances .

目的：建立测定人唾液中依诺沙星浓度的RP-HPLC法。

Objective : A RP-HPLC method has been developed for the determination of enoxacin in human saliva .

恩诺沙星对鸡细胞色素P450酶系的影响

Effects of Enrofloxacin on Cytochrome P450s in Chickens

Nafion修饰电极测定动物血清中马波沙星

Determination of marbofloxacin in animal serum at a Nafion-modified electrod

恩诺沙星在天然水中的降解与光照有关，在室外自然光照条件下恩诺沙星降解很快，3d后水中已经检测不出恩诺沙星。

The degradation of enrofloxacin in natural water was strongly affected by light . Under outdoor natural light condition , enrofloxacin degraded quickly and was not examined after 3 days ;

在NaCl含量0.85%～5.00%的培养基中能够生长；恩诺沙星、诺氟沙星对其有抑制作用。

It could grow in the solid culture added 0.85 % ~ 5.00 % NaCl and was inhibited by enrofloxacin and norfloxacin .

目的：建立科学合理的高效液相色谱法（HPLC）测定甲磺酸培氟沙星注射剂的有关物质及含量。

Objective : To establish a High Performance Liquid Chromatography ( HPLC ) method to determine related substance and assay in Pefloxacin Mesylate Injection and Pefloxacin Mesylate for Injection .

给10头猪分别按体重5mg／kg单剂量内服和肌注恩诺沙星。

Ten pigs were treated with enrofloxacin by oral or intramuscular administration , at a single dosage of 5 mg / kg .

左旋氧佛沙星凝胶与左旋氧氟沙星单体MIC、MBC值无显著差异；

The MIC and MBC of Levofloxacin gel and Levofloxacin had no significant difference without any harmful effect .