水蛭

单相思如同一只贪婪的水蛭，吸走了我的时间和欢笑。

One-side love like a greedy leech absorbed my time and my mirth .

复方水蛭滴眼液抑制H2O2诱导的晶状体上皮细胞凋亡的信号转导机制研究

The Signal Transduction Mechanism of Inhibitory Effect of Compound Leech Eye Drops on Apoptosis of Lens Epithelial Cells

布鲁赛是第一个把水蛭当成万灵药的医生。

Broussais was the first physician to use leeches as a cure-all .

五种水蛭对不同pH值的生物效应

Biological effect of pH values on 5 species of common leeches

以次黄嘌呤为考察指标，建立了水蛭注射液的HPLC指纹图谱。

HPLC fingerprint of hirudo injection was established , using hypoxanthine as the target .

建立了HPLC法测定水蛭提取液中总氨基酸和游离氨基酸的含量。

HPLC method was established for the determination of total amino acids and free amino acids in hirudo extract .

目的观察渗滤法水蛭提取液对体外培养视网膜色素上皮细胞（RetinalPigmentEPithelium，RPE）增殖的影响。

OBJECTIVE To observe effect of hirudinoid extract by percolation leech on proliferation of retinal pigment epithelium ( RPE ) cultured .

从而探讨中药水蛭用于防治PVR的作用机制。

For exploring effect and mechanism of leech preventing and curing PVR .

水蛭微粉对急性脑梗塞患者血液vWF、GMP-140的影响

Effect of vWF , GMP-140 of ultra-fine particle of leeches in treating acute brain infarction disease

水蛭桃仁汤对肝纤维化大鼠HSC活化及TGFβ1表达的影响

Effects of Decoction of Leech and Peach Kernel on Activation of HSC and Expression of TGF - β 1 in Rat Liver Fibrosis

大鼠脑缺血-再灌注的C3、C4和NO变化及复方水蛭合剂对其影响

Changes of C3 , C4 and NO after Cerebral Ischemia Reperfusion in Rats and the Effect of Complex Hirudo

不同炮制工艺水蛭的水溶性蛋白组成的差异检测采用SDS-PAGE，定量分析采用ScionImage软件；

The difference of the components of water-solubility proteins in leech between the two processing technology was qualitatively and quantitatively determined by SDS-PAGE and Scion Image software .

水蛭微粉对脑缺血再灌注损伤大鼠ICAM、VCAM、PDGF的影响

Effect of Hirudo Micropowder on ICAM , VCAM and PDGF in Rats with Cerebral Ischemia-Reperfusion Injury

结论：早期应用水蛭注射液溶栓治疗AMI，可明显提高冠脉再通率，降低病死率，有较好的溶栓效果。

Conclusions : The solving thrombus therapy of leech injection in early stage can improve the reflowing rate of coronary artery , and decrease mortality with good solving thrombus effect .

目的观察水蛭粉及煎剂对老龄自发性高血压大鼠（SHR）血压、血脂及血流动力学的影响。

Aim To investigate the effects of powder , decoction Leech on blood pressure , blood lipid and hemorrheology of old spontaneously hypertensive rat ( SHR ) .

方法：以二甲基亚硝胺（DMN）制备大鼠肝纤维化模型，同时给予水蛭桃仁汤灌胃治疗。

Methods : The rat liver fibrosis model was induced by the intraperineal injection of Dimethylnitrosamine ( DMN ) .

目的观察水蛭提取液对视网膜色素上皮细胞（RetinalPigmentEPithelium，RPE）内游离钙离子（Intracellularlibercalciumion，[Ca2+]i）浓度的影响。

OBJECTIVE To observe effect of percolation leech extract on intracellular liber calcium ion [ Ca ~ ( 2 + ) ] I of retinal pigment epithelium ( RPE ) cultured in vitro .

结果：用药各组均有明显降低TC、TG、LDL-C及升高HDL-C作用，以复方水蛭胶囊高剂量组为优。

Results : All medicines had the notable effects of decreasing TC , TG , LDL-C and increasing HDL-C. The effect in group treated with high-dosage TCM was the most significant .

结论：水蛭桃仁汤对DMN诱导的实验性大鼠肝纤维化具有良好的防治作用。

Conclusion : Decoction of leech and peach kernel showed good effects on the treatment of hepatic fibrosis induced by DMN .

目的：用晶体混浊分类系统Ⅲ（lensopacitiesclassificationsystemⅢ，LOCSⅢ）探讨复方水蛭（shuizhi，SZ）滴眼液对老年性白内障的防治作用。

AIM : To investigate the protection and treatment of compound leech ( Co SZ ) eye drops on senile cataract by the lens opacities classification system ⅲ ( LOCS ⅲ) .

水蛭提取液体外对人视网膜色素上皮细胞PAR-1表达的影响

Influences of leech extracting solution on expression of thrombin receptor-1 in cultured human retinal pigment epithelial cells

水蛭对VEGF-mRNA的表达具有一定的促进作用。

The Leech can promote for expression of VEGF - mRNA .

目的：研究水蛭注射液对小鼠体内血栓形成和血浆纤溶酶原激活物（tPA）及抑制物（PAI）的影响。

Objective : To investigate the effect of leech injection on thrombosis and plasma tissue plasminogen activator ( t PA ) and its inhibitor ( PAI ) in the thrombosis model of mice .

结果：水蛭免加热提取物能延长高凝模型小鼠的BT、CT和高凝模型大鼠的PT、APTT，抑制凝血因子Ⅱ的活性，降低血小板聚集率。

Results : Non-heating leech extract was able to prolong BT and CT in the model mice , PT and APTT in the model rats and to decrease activity of coagulation factor ⅱ and platelet aggregation in the model rats .

结果五种水蛭提取液抑制LEC生长的24h、72hID（50）介于20.56mg／ml至68.78mg/ml之间，其中水提醇沉液、渗滤液具有更明显生长抑制作用（P＜0.05）；

Results The ID50 of these extracting solution exposed to LEC for 24h and 72h were between 20.56mg/ml to 68.78mg / ml , and inhibition of water extracting-alcohol precipitating solution and percolation filtration solution was more strongly ( P < 0.05 );

目的探讨光化学法诱导大鼠脑血栓形成中丙二醛（MDA），NO和SOD含量的变化及水蛭提取物（EFH）对其脑组织保护作用的机理。

AIM To observe changes in contents of malondialdehyde ( MDA ), SOD and NO during photo-chemically induced thrombosis in the rat 's brain , and to study mechanism of EFH in protection of its brain .

目的：观察水蛭桃仁汤对肝纤维化大鼠肝星状细胞（HSC）活化及转化生长因子β1（TGFβ1）表达的影响，并探讨其对肝纤维化是否具有治疗作用及其作用机制。

Objective : To study the effects of Decoction of leech and peach kernel on activation of HSC and expression of TGF - β 1 in rat liver fibrosis and investigate the possible mechanisms of it in protection of liver fibrosis .

结果：水蛭注射液能显著降低脑缺血再灌注损伤大鼠脑组织含水量及Ca2+含量，降低血清及脑组织中MDA，NO的含量，提高SOD的活性。

Results : Compared with the control group , the injection could greatly lower the water contents , Ca 2 + contents in the rat brain tissue and MDA and NO contents in brain homogenate and blood serum and increase SOD activity in the treatment group .

hVEGF（165）和嵌合水蛭肽融合基因的构建、表达和活性检测

Construction , Expression and Characterization of a Fusion Gene of hVEGF_ ( 165 ) and Fused Hirudin Peptide

并观察水蛭粉（250mg/kg口服，每天2次，治疗5d）治疗脑水肿的疗效。

Twenty rats were treated with hirudo powder ( 250mg / kg , twice daily for 5d , po ) . Brain water and electrolyte levels in these rats were measured at different times .