染色体不分离

结果提示TOPOⅡα表达的变化是小剂量照射引起有丝分裂染色体不分离的机制之一。

The results suggest that low dose irradiation may causes chromosome non-disjunction , and its mechanism is related with the change of TOPO ⅱ α expression .

结论低剂量电离辐射是引起卵细胞染色体不分离的重要环境因子。

Conclusion : Low dose irradiation can cause meiotic chromosome non-disjunction .

小剂量电离辐射引起体细胞染色体不分离及其与拓扑异构酶Ⅱα的关系

Effects of low dose radiation on chromosome non-disjunction and the relation with topoisomerase ⅱα

低剂量电离辐射引起小鼠胚胎上皮细胞中染色体不分离的研究

The effect of low dose ionizing radiation on meiotic chromosome non - disjunction of mice

21号染色体不分离与年龄的关系极显著，无论在体内还是体外，21号染色体不分离远远高于丢失。

Nondisjunction of chromosome 21 is much more frequent than loss in vivo and in vitro .

重组异常是染色体不分离的重要风险因子，并可能进一步导致不育。

Altered recombination may be an important risk factor for non-disjunction , which in turn contributed infertility .

结论同源染色体不分离和姐妹染色单体平衡性及非平衡性过早分离这三种机制均参与了卵细胞非整倍体的产生。

Conclusion Both nondisjunction , balanced and unbalanced predivision of chromatids are involved in the oocyte aneuploidy formation .

研究结果表明，紫鸭跖草（Tradescantiareflexa）植物具有较高的染色体不分离自发频率，是一种研究诱发非整倍性的较好体系。

Tradescantia reflexa plant which has high spontaneous frequencies of non-disjunction is an ideal system for the study of aneuploidy induction .

在减数分裂的过程中同源染色体不分离而造成的一条或多条染色体的缺失或增加。

Aneuploidy The condition , resulting from nondisjunction of homologous chromosomes at meiosis , in which one or more chromosomes are missing from or added to the normal somatic chromosome number .

小剂量电离辐射引起人淋巴细胞染色体的不分离

Effect of low dose ionizing radiation on human lymphocytes chromosome non-disjunction

STR-PCR分析诊断常见染色体三体及其亲源性、染色体不分离时期

Diagnosis of Common Trisomies and Identification of Parental Origins of Extra Chromosomes and Stages of Nondisjunction by STR-PCR Analysis

unicolor小孢子母细胞减数分裂异常进行了研究，发现存在不等二价体、同源染色体早分离、染色体桥、不均等分离、滞后染色体、核外染色体、微核等。

There were unequal bivalents , homologous chromosome deconjugation , chromosome brige , unequal separation , laggard chromosomes , chromosome outside nucleus , micronuclei and so on .

结论：根据这3个遗传标记可确定大多数先天愚型患儿额外染色体的双亲起源，为研究染色体不分离的机制奠定基础。

Conclusion : The parental origin of the extra chromosome 21 can be detected in most Down syndrome using these three loci , and this experiment is helpful to illustrate the mechanism of chromosome nondisjunction .

目的：本文从DNA分子水平对Klinifelter综合征患者及双亲X染色体着丝粒区域的α-卫星DNA变异进行研究，探讨Klinefelter综合征患者X染色体不分离形成的原因。

Objective : To study the variation of X chromosome centromeric Alpha Satellite DNA in Klinefelter 's syndrome patients , their parents and normal individuals and to discuss the mechanism of Klinefelter 's syndrome X chromosome nondisjunction .

88-428BY-827雄性不育株小孢子母细胞减数分裂的染色体的行为出现了多种类型的异常现象：联会异常、单价体、三价体、染色体落后、染色体粘连、染色体桥、染色体不均等分离等；

Different kinds of abnormal chromosomal behavior occurred at its meiosis of the pollen mother cell of the sterile plant including the synaptic variation , univalent , trivalent , chromosome lagging , chromosome hauling , chromosome bridge , chromosome sticking and unequal distribution , etc.

采用STR-PCR技术，扩增21号染色体4个位点；18、13号染色体各3个位点，诊断这些染色体三体综合征，与染色体核型对照：并判断额外染色体双亲来源和染色体不分离发生时期。

STR-PCR technique was used to amplify 4 loci on chromosome 21 , 3 loci on chromosome 18 and 3 loci on chromosome 13 to diagnose those chromosomal trisomies as well as the parental origins of the extra chromosomes and the stages of nondisjunction .