染色体融合

白血病和淋巴瘤常见染色体融合基因的检测分析

Detection and Analysis of Common Fusion Genes Related to Leukemias and Lymphomas

结论一步法RT-PCR技术检测染色体易位融合基因为临床RMS疑难病例的诊断和研究提供了有效技术手段；

Conclusion One-step RT-PCR assay for detection specific fusion gene provides a useful tool for confirmation of the diagnosis of RMS in diagnostically difficult cases and in retrospective studies .

结果该患儿经骨髓细胞形态学、染色体以及融合基因检查确诊为APL，缓解期间PML/RARα融合基因始终阳性；

Results This child was diagnosed as APL through the examination of blast cell morphology , chromosome and blending gene . The blending gene of PML / RAR α was positive during the complete remission .

特定的染色体和融合基因可作为白血病的标志物，对白血病的诊断、预后估计、监测治疗和微小残留白血病等方面具有一定的价值。

The specific chromosome and fusion gene are regarded as marker of leukemia , and helpful in leukemia diagnosis , evaluating prognosis , monitoring of treatment and minima residual leukemia .

Ph染色体阴性bcr/abl融合基因阳性2例，最长生存27个月。

Two cases with Ph chromosome negative but bcr / abl fusion gene positive , and they had survived 2 ~ 27 months .

目的：观察Ph染色体，bcr/abl融合基因与慢性粒细胞白血病（CML）的诊断指标。

Objective : To investigate the value of detection of Ph chromosome and bcr / abl fusion gene in the diagnosis of CML .

目的了解儿童急性髓细胞性白血病（AML）染色体及相关融合基因的变化。

Objective To investigate the chromosomal abnormalities and fusion genes of childhood acute myeloid leukemia ( AML ) .

结论儿童AML进行染色体分析及融合基因的检测，有助于AML诊断及亚型之间的鉴别诊断。

Conclusion Chromosome analysis and detection of fusion genes are helpful in the diagnosis of AML and the differentiation diagnosis of AML subtype .

4例慢性髓细胞白血病（CML）经alloPBSCT后，Ph染色体和bcr/abl融合基因阳性1例，经供者淋巴细胞输注加干扰素治疗，已生存70个月。

In four CML patients after allo-PBSCT , one had Ph chromosome positive and bcr / abl fusion gene positive , and he had survived up to 70 months after donor lymphocyte infusion and interferon treatment .

目的：探讨Ph1染色体和bcr/abl融合基因检测在慢性粒细胞白血病诊断中的意义。

Objective To study the clinical significance of detection of Ph 1 chromosome and bcr / abl fusion gene in the diagnosis for chronic granulocytic leukemia .

结论：Ph1染色体、bcr/abl融合基因的检测有助于慢性粒细胞白血病的诊断和鉴别诊断。

Conclusion The results indicated that the detection of Ph 1 chromosome combined with bcr / abl fusion gene could improve the diagnosis and differential diagnosis of chronic granulocytic leukemia .

90%以上患者骨髓细胞中有特征性的费城染色体或BCR/ABL融合基因，中位生存期为3&4年。

More than 90 percent patients ' myelocytes have characteristic Ph chromosome or bcr / abl fusion gene . Most patients exist three or four years . Chronic myelocytic leukemia is one of malignant diseases which threaten to our health seriously .

本研究的目的旨在了解急性髓细胞性白血病患者染色体核型及融合基因的分布规律，同时结合国内外细胞遗传学危险度划分标准，了解核型与预后的相关性。

The purpose of this article is to study the distribution of karyotype and the relationship between chromosome abnormalities and prognostic in AML according to known domestic and international hierarchical cytogenetic classification . Methods : Cytogenetic examination of bone marrow cells was performed by short-turn culture method .

9号和22号染色体相互易位形成融合基因bcr／abl，是慢性粒细胞性白血病（CML）的主要发病机制。

Chronic myeloid leukemia ( CML ) is characterized by the reciprocal translocation of chromosome 9 ;

秋水仙碱阻滞细胞周期于分裂中期，DAPI荧光染色分析染色体端-端融合；

Cell cycles were blocked in metaphase by colchicina . Chromosome end-to-end fusions were analyzed by DAPI fluorescein stain .

目的研究儿童急性髓细胞性白血病（AML）染色体畸变所形成融合基因的临床和实验关系。

Objective To investigate the fusion genes derived from chromosome structural aberrations in children with acute myelocytic leukemia determined by multiplex RT_PCR and explore its potential clinical significance in diagnosis , treatment and prognosis evaluation .

本研究旨在探讨急性髓系白血病（AML）患者6；9染色体易位与DEK-CAN融合基因表达之间的关系及临床意义。

This study was aimed to explore the relationship of6 ; 9 chromosome translocation with DEK-CAN fusion gene expression in patients with acute myeloid leukemia ( AML ) and its clinical significance .

SSX基因家族由9个成员组成，其中ssx-1、SSX-2和SSX-4经常出现在滑膜肉瘤t（x：18）染色体易位的SYT-SSX融合基因中。

The SSX gene family is composed of 9 members , among which SSX-1 , SSX-2 , and SSX-4 have been found existing in SYT-SSX fusion gene resulting from the t ( X : 18 ) chromosomal translocation in almost all synovial sarcomas .

白血病29种染色体畸变形成的融合基因分析

Analysis of fused genes resulting from 29 chromosomal aberrations in leukemia

造血干细胞移植后白血病细胞染色体核型和bcr/abl融合基因表达观察

Detection of chromosome karyotype and bcr / abl fusion gene after hematopoietic stem cell transplantation in leukemia

端粒（telomere）是位于真核细胞线性染色体末端的天然结构，对于保护染色体、防止染色体融合、降解是非常重要的。

Telomere is natural structure located at the ends of linear eukaryotic chromosomes , which is essential for protecting chromosomes from degradation and fusion .

端粒蛋白质-DNA功能复合体不稳定会在染色体末端引起DNA损伤反应，导致细胞衰老、凋亡、染色体末端融合和基因组不稳定性等严重细胞生物学后果。

The instability of telomere DNA – protein function complex at the end of chromosome will cause DAN damage , and then leads to severe cell biology consequences including cell senescence , cell death , end-to-end fusion of the chromosome , genomic instability and so on .

端粒酶维持线形染色体的端粒末端结构的完整性，防止染色体的缩短及与其它染色体的融合。

Telomerase maintains the telomeric ends of linear chromosomes and protects them from degradation and end-to-end fusion .