普萘洛尔

双相识别HPLC法拆分普萘洛尔对映体

The Resolution of Propranolol Enantiomers by HPLC with Two-Phase Discrimination

尿中普萘洛尔对映体葡醛酸苷的HPLC测定

Determination of Propranolol Enantiomer Glucuronides in Urine by HPLC

HPLC手性离子对试剂法拆分普萘洛尔对映体

Resolution of Propranolol enantiomers by HPLC with chiral ion pair agent

普萘洛尔对21例长QT综合征的临床疗效观察

The Clinical Effect of Propranolol on Long QT Syndrome in 21 Patients

盐酸普萘洛尔脂质体鼻腔喷雾剂的研究HPLC法测定盐酸纳洛酮鼻腔喷雾剂的含量及有关物质

Studies on Nasal Nebula of Propranolol Hydrochloride-Containing Liposome Determination of Naloxone Hydrochloride Nasal Sprays and Its Related Substances by HPLC

结果1.普萘洛尔+光动力组较普萘洛尔组、光动力组抑制内皮细胞增殖作用强（P0.05）。

The cytostatic action of propranolol and photodynamic therapy was Stronger than propranolol or photodynamic therapy ( P0.05 ) 2 .

结论普萘洛尔能有效地预防OVX大鼠的骨丢失，同时降低血清IL-6水平。

Conclusion Propranolol prevent bone loss and reduce serum IL-6 in OVX rats .

普萘洛尔在人肝细胞色素P450转基因细胞中的立体选择性测定

Stereoselective determination of propranolol enantiomer in transgenic cell lines expressing human cytochrome P450

目的：确定口服普萘洛尔（Pro）的体内分布与代谢是否在健康中国人中存在性别二态性。

AIM : To determine if the gender-based dimorphism of the distribution and metabolism of oral propranolol ( Pro ) exists in the healthy Chinese volunteers .

依那普利和硝苯地平组CMAI较普萘洛尔组明显升高（p＜0.05）。

The CMAI obviously heightened in enalapril or valsartan groups compared with propranolol group ( p < 0.05 ) .

本文采用离体兔门静脉环的方法，观察了普萘洛尔（Propranolol，Pro）和维拉帕米（Verapamil，Ver）对门静脉血管的作用。

The effects of propranolol and verapamil on portal vein vessels were studied in rabbits isolated portal vein rings in this paper .

盐酸普萘洛尔（Propranolol）是非选择性、抑制、竞争肾上腺素的阻滞剂，针对于β受体。

Propranolol hci ( Propranolol ) is selective , inhibit , competition adrenaline blockers , aim at the beta receptors .

结果：施他宁和普萘洛尔均能降低PVP、GMBF，而对胃粘膜下层血管无影响；

Results : GMBF and PVP were reduced whereas submucosal blood vessels were not changed after intravenous stilamin and propranolol .

方法：通过显微镜观察细胞形态学特点，测定跨上皮细胞膜电阻，碱性磷酸酶活性和标志物普萘洛尔的转运特性等指标对Caco-2细胞模型进行评价。

Methods : Caco-2 cell model was evaluated by morphology feature , TEER alkaline phosphatase and the transport of Propranolol .

此结果提示，普萘洛尔参与了血浆ANP水平的调控，这种作用尚难以用β肾上腺素能效应进行解释，可能与抑制ANP的体内降解过程有关。

These results suggest that propranolol is involved in the control of plasma ANP level , and beta-adrenoceptor mechanisms are not directly responsible for the regulation .

目前研究表明普萘洛尔可通过抑制NE诱导的MMPs分泌从而逆转其促肿瘤侵袭作用，但其内在机制尚不明确。

The present study showed that propranolol can inhibit the NE-induced MMPs secretion and thus reversed the induction of tumor invasion and its internal mechanism is not yet clear .

静脉给予β受体阻断剂普萘洛尔，可部分削弱EA对胃黏膜损伤的保护作用，与0.85%氯化钠组比较P<0.01；

Injection of β receptor blocker propranolol could partly weaken the protective role of EA in gastric mucosa lesion , and the significant difference between the propranolol group and the 0.85 % saline group .

目的探讨抗心律失常药盐酸普萘洛尔（PL·HCL）在猪口腔颊黏膜上的渗透作用及药物经口颊黏膜吸收的影响因素。

Purpose To investigate the permeation of model drug , propranolol hydrochloride , through the excised porcine buccal mucosa . To study the influences of various factors on the buccal absorption also studied .

目的探讨普萘洛尔对高脂血症兔外周血白细胞CD11a的表达及动脉粥样硬化病变形成的影响。

Aim To observe the effects of propranolol on peripheral blood leucocyte CD11a expression of experimental hyperlipemia rabbits and the formation of atherosclerosis .

近来研究表明应激激素尤其是去甲肾上腺素可明显促进多种恶性肿瘤的侵袭，而应用β受体阻滞剂普萘洛尔（Propranolol）可以有效地逆转该效应。

Recent studies have shown that stress hormones-especially norepinephrine could promote the invasion of various malignant tumors . The β - blocker , propranolol can effectively reverse the effects above .

目的：观察普萘洛尔、司坦唑与左旋米唑联合用药（PSL）治疗再生障碍性贫血的疗效。

AIM : To observe the therapeutic results of the combination regimen of propranolol , stanozolol , and levamisole ( PSL ) on aplastic anemia .

方法：制备豚鼠离体气管环标本，通过测定其张力变化，观察Sco对离体气管平滑肌的舒张作用及与组胺（His）、乙酰胆碱（Ach）、普萘洛尔（Pro）之间的相互作用。

Methods : By measuring the force of guinea pig isolated tracheal rings , we observed both relaxing effect of Sco and interactions between Sco and histamine ( His ), acetylcholine ( Ach ) or propranolol ( Pro ) on isolated TSM .

普萘洛尔可以增高血清瘦素水平，增加去卵巢大鼠下丘脑瘦素全长受体Ob-R的表达，对长型受体Ob-Rb的影响不明显，OB-Rb／Ob-R的比值下降，导致瘦素在中枢神经系统敏感性下降。

Conclusions Propranolol prevented bone loss of ovariectomized rat . Propranolol can increased serum Leptin level and decreased the ratios of Ob-Rb and OB-R in OVX rats .

基于盐酸普萘洛尔诱导纳米金团聚并使溶液瑞利散射光（RLS）强度显著增强的现象，提出了瑞利散射光谱分析盐酸普萘洛尔的新方法。

The addition of propranolol to the solution of gold nanoparticle could induce its aggregation and the RLS intensity would increase quickly , based on which , a novel approach for the determination of propranolol by RLS spectrum was proposed .

结果显示，脂质体制剂与药物水溶液相比，可显著降低盐酸普萘洛尔的鼻纤毛毒性，纤毛运动时间由5min延长到250min；

The conclusion was that the liposome preparation had less toxicity than its solution , for example it prolonged the ciliary vibration duration from 5 minutes to 250 minutes .

目的研究应激对实验性家兔动脉粥样硬化（AS）斑块的病理形态学和外周血黏附分子CD11a的影响及普萘洛尔的干预作用，以探讨普萘洛尔稳定AS斑块的免疫学机制。

Objective To study the effects of psychological stress on experimental rabbit atherosclerotic plaque pathomorphology and peripheral blood adhesion molecule CD11a and intervenient action of propranolol , in order to find out the immunological mechanism of propranolol in stabilizing atherosclerotic plaque .

普萘洛尔组动脉粥样硬化斑块面积与内膜面积比为59.1%±11.3%，斑块内巨噬细胞含量为56.3%±4.9%，外周血CD11a阳性的白细胞比率为61.9%±4.2%；

In propranolol group , the ratio of atherosclerotic plaque area to intima area and content of macrophage and the positive percentage of peripheral blood leucocyte CD11a expression were 59.1 % ± 11.3 % , 56.3 % ± 4.9 % , 61.9 % ± 4.2 % respectively .

布诺洛尔和普萘洛尔对β肾上腺素受体阻断作用的比较

Beta-adrenergic receptor blocking effect of bunolol : a comparison with propranolol

肾上腺素能受体拮抗剂普萘洛尔和哌唑嗪对应激大鼠的影响

The Effects of Adrenoceptor Antagonist Propranolol and Prasozin on Stressed Rats

普萘洛尔对T波异常者倾斜试验的影响

The effect of propranolol on T wave abnormalities in tilt test