抗肿瘤药物

DNA拓扑异构酶Ⅱ与抗肿瘤药物靶点的研究进展

New research approaches in DNA topoisomerase ⅱ targets and antitumor drug

以调控Ras信号传导为靶标的抗肿瘤药物研究进展

Progress in the study of antitumor drug targeting on the Ras signaling pathway

其中，许多临床上使用的抗肿瘤药物的作用机理涉及到DNA的交联。

Many anticancer drugs are involved in DNA cross-linking mechanism .

抗肿瘤药物与DNA相互作用的热动力学规律

Thermokinetic rules of mutual effect between antitumour drugs and DNA

以DNA拓扑异构酶为靶点的抗肿瘤药物筛选

Screening for Antitumor Drugs Targeting DNA Topoisomerases

在生物医用材料方面的应用主要包括抗肿瘤药物、DNA荧光探针和荧光分子开关；

The applications in the biomedical materials included mainly anticancer drugs , DNA fluorescence probe and fluorescence molecular switch .

野生型p53基因替代结合抗肿瘤药物对于提高肿瘤细胞的药物敏感性，克服耐药方面可能有一定的帮助。

Wild-type p53 substitution therapy may enhance the sensitivity of lung cancer to chemical drugs .

以人MMP-2和整合素αvβ3为靶点的抑制新生血管生成的抗肿瘤药物研究

The Studies of the Anti-angiogenesis Drug Directed Against Human MMP-2 and Integrin α _v β _3

Survivin特性与抗肿瘤药物研究

Research of specific properties of survivin and anti-tumor drugs

基于c-myc启动子的抗肿瘤药物筛选系统

C-Myc Promoter Based Anti-Tumor Drug Screening System

长春新碱（VCR）为重要和常用抗肿瘤药物之一。

Vincristini sulfas ( VCR ) is an important common antitumor drug .

抗肿瘤药物的研究Ⅹ.放线菌素K对Ehrlich腹水癌细胞核分裂的影响

Studies on antitumor drugs ⅹ . the effect of actinomycin K on mitosis of Ehrlich ascites carcinoma cells

采用微量热方法，从热动力学角度，建立抗肿瘤药物与DNA作用的热动力学模型，计算系列相关的热力学函数。

Using the means of microcalorimetry , from the view of thermokinetics , we established thermokinetic model of mutual effect between antitumour drugs and DNA , calculated mutual thermodynamic function .

PHA体外增强某些抗肿瘤药物对小鼠肝癌细胞DNA合成的抑制作用

The Enhancing Effect of PHA on the Inhibition of DNA Synthesis of Hepatocarcinoma Cells of Mice in vitro by Some Antitumor Drugs

本文就肿瘤血管生成、VEGF家族的特性、VEGF在抗肿瘤药物开发中的应用做一综述。

This thesis gives a review on tumor angiogenesis , the features of VEGF family , the application of VEGF on anti-tumor drugs .

靶向蛋白激酶AuroraA的抗肿瘤药物筛选模型的建立和评价

Establishment Models to Screen for New Antitumor Drugs Targeting Aurora A Kinase Inhibitors

基于GFP的荧光成像方法具有在细胞水平和活体水平抗肿瘤药物筛选的潜力。

GFP-based optical imaging has potential to screen antitumor drugs at cellular and in vivo levels .

方法用MTT比色法测定Ma及Ma联合常用抗肿瘤药物对K562细胞的抑制率。

Methods MTT colorimetric assay was used to detect the inhibition rate of Ma combined with antineoplastic on K562 cells .

SPC-A1/TAX较SPC-A1除对原诱导药物TAX具有耐受性外，对其他5种抗肿瘤药物也表现出不同程度的耐药性。

In addition to the original repulsive TAX , SPC-A_1 / TAX cells also resisted to other 5 anticancer drugs .

多糖修饰的PLGA纳米粒作为抗肿瘤药物载体的研究

The Study of PLGA Nanospheres Surface Modified with Biotinylated Chitosan as the Antitumor Drug Delivery Carriers

实验结果表明N-琥珀酰壳聚糖和K562肿瘤细胞间存在着较强的亲和性，可以作为抗肿瘤药物的靶向载体，并且随着分子量的增加，其亲和性逐渐减弱。

The results indicated that N-Succinyl-Chitosan demonstrated high affinity for K562 leukemia cell declining with the increasing of MW of chitosan .

苦参碱（Mat）是豆科槐属植物苦豆子的主要生物碱，是一种新型的抗肿瘤药物。

Matrine ( Mat ) is the main alkaloid of foxtail-like sophora herb and seed and one of newfashioned antitumor drugs .

为此我们建立了基于c-myc启动子的新型抗肿瘤药物筛选系统，用于抗肿瘤药物的筛选和研究药物作用机理，并对这一系统从原则上进行了验证。

For this reason we developed a c-myc promoter-based cell system for the screening and mechanism study of anti-cancer drugs .

microRNA影响抗肿瘤药物敏感性相关研究进展

Progression of anti-tumor drugs ' sensitivity influenced by microRNA

抗肿瘤药物的研究Ⅸ.Sb-71对Ehrlich腹水瘤细胞核分裂的影响

Studies on antitumour drugs ⅸ . effects of sb-71 on mitosis in Ehrlich carcinoma cells

这些化合物是一类具有应用研究前景的先导化合物，对于开发新一代MMP抑制剂类抗肿瘤药物具有重要意义。

These compounds are promising lead compounds for application prospect and developing new generation of MMP inhibitors as antitumor agents .

前者主要作用于增殖周期各期的细胞，包括G0期细胞，这类药物包括烷化剂和大部分抗肿瘤药物，其疗效与剂量成正比，即呈现出剂量依赖性，以大剂量冲击治疗为主；

The former mainly contributes to the cells of reproductive cycle , including G_0-stage cells , and this kind of drugs consists of aldyl agents and antineoplastic antibiotics , whose therapeutic effects are dose-dependent .

以PI3K信号通路中关键分子为靶点的抗肿瘤药物研究成为肿瘤靶向治疗的热点之一。

Targeting the key components of PI3K pathway has become one of the hotspots in anticancer drug developments .

实验用药：表阿酶素（E-ADM）和丝裂酶素（MMC）为含有活性醛基的抗肿瘤药物；

E-ADM and MMC were experimental drug consisting of active aldehyde group .

目的探讨职业接触抗肿瘤药物对护士外周血淋巴细胞凋亡及Fas、bcl-2基因表达的影响。方法选择接触抗肿瘤药物5年以上，每日接触5人次以上的护士为接触组；

Objective To study the effects of antineoplastic agents on lymphocyte apoptosis and expression of Fas , bcl-2 gene in nurses with occupational exposure to these drugs .