抑肽酶

结论用抑肽酶行脾动脉灌注、明胶海绵栓塞是治疗脾破裂Gall分级Ⅰ～Ⅲ级可靠而有效的方法；

Conclusions Trasylol perfusion and gelatin sponge embolization of the splenic artery is a reliable and effective way for treatment of splenic rupture with Gall grades of ⅰ to ⅲ .

本实验观察了国产加贝酯对大鼠实验性急性胰腺炎的治疗效果，并与进口药品FOY及抑肽酶作了比较。

The effects of Gabexate mesilate made in China in the treatment of acute experimental pancreatitis was observed , and was compared with that of FOY and Trasylol in the rats with acute pancreatitis .

结果：抑肽酶组较对照组术后失血和血制品的使用明显减少（P＜0.01）。

Results : In patients given aprotinin , postoperative blood loss and use of blood products were significantly low ( P < 0.01 ) .

方法取30只雄性新西兰家兔，随机分成三组：对照组（C组）、抑肽酶组（A组）和乌司他丁组（U组），建立兔在体肾脏缺血再灌注损伤模型。

Methods 30 rabbits were randomly divided into control group , aprotinin group and ulinastatin group respectively , and rabbit ischemia-reperfusion injury model was established .

选择健康献血员及心内直视手术病人，观察抑肽酶对全血活化凝血时间（ACT）的影响。

E selected healthy volunteers and patients undergoing cardiopulmonary bypass ( CPB ) to evaluate the effects of aprotinin on the activated clotting time ( ACT ) .

抑肽酶对常温体外循环中TNF-α、IL-6及IL-8的影响

Effects of aprotinin on expression of TNF - α, IL-6 , and IL-8 after warm cardiopulmonary bypass

抑肽酶对围术期急性失血性休克DIC转归的保护作用

Protection of Aprotinin on perioperative DIC following acute hemorrhagic shock

抑肽酶对心瓣膜置换术患者围术期IL-6、IL-8释放的影响

Effect of Aprotinin on IL-6 and IL-8 in the Serum of Patients with Cardiac Valve Replacement During Perioperative Period

抑肽酶对体外循环中性粒细胞CD（11b）表达的研究

Effect of Aprotinin on CD_ ( 11b ) Expression of Neutrophilic Granulocytes in Cardiopulmonary Bypass

抑肽酶抑制中性粒细胞对TNFα活化的人脐静脉内皮细胞黏附和迁移的实验研究

The Effect of Aprotinin on Polymorphonuclear Neutrophils ( PMN ) Adhesion and Transmigration Through TNF α Activated Human Umbilicus Vein Endothelial Cells in Vitro

目的：探讨抑肽酶和肿瘤坏死因子α（TNFα）抗体对大鼠肝缺血再灌注损伤的保护作用。

Objective : To study the protective effects of aprotinin and tumor necrosis factor α( TNF α) antibody on liver ischemia reperfusion injury in rats .

肾脏显象剂&~（99m）Tc-（Sn）-抑肽酶的制备及动物实验

A renal imaging agent ~ ( 99m ) tc ( sn ) aprotinin and its preparation and animal experiments

结论：含抑肽酶的肺保护液对肺的保护效果确切，其保护作用明显优于单纯LPD液。

Aprotinin contained lung preservation solution is superior to LPD for lung protection .

目的探讨小剂量抑肽酶对体外循环（CPB）下心脏手术术后出血的影响。

Objective : To study the effect of low dose aprotinin on postoperative blood loss of cardiosurgery after cardiopulmonary bypass ( CPB ) .

研究目的：观察小剂量抑肽酶及甲基强的松龙对体外循环（CPB）炎性反应的影响。

Objective : To observe the effects of low-dose aprotinin and methylprednisolone on the inflammatory response induced by cardiopulmonary bypass ( CPB ) .

大剂量抑肽酶组：CPB前静给抑肽酶200万KIU，随后持续静滴50万KIU／h至关胸结束，预充液中加入200万KIU。

High - dose aprotinin group .

心脏手术中小剂量抑肽酶对中性粒细胞CD（11b）/CD（18）表达的影响

The effect of low-dose aprotinin on the expression of neutrophil CD_ ( 11b ) / CD_ ( 18 ) in open heart surgery

应用抑肽酶阻断纤溶酶活性后能够完全阻断proMMP2与proMMP9的活化。

Inhibiting the activity of plasmin by aprotinin could totally block the conversion of pro-MMP-2 / 9 to active enzyme .

目的观察体外循环（CPB）心脏瓣膜置换手术中使用大剂量抑肽酶对心肌的保护作用。

Objective To investigate the myocardial protective effects of large dose of aprotinin on myocardium during cardiac valvular replacement operation under cardiopulmonary bypass ( CPB ) .

目的观察小儿体外循环术中、术后细胞因子肿瘤坏死因子（TNF）α、白细胞介素（IL）6、IL8的变化，评价抑肽酶对体外循环炎性反应的抑制作用。

Objective : To evaluated the inhibitory effects of aprotinin on plasma TNF α, IL 6 , IL 8 during and after cardiopulmonary bypass in children .

抑肽酶可抑制TNFα活化的人脐静脉内皮细胞ICAM-1的表达，可避免β-catenin的丢失。

Aprotinin could downgrade the expression of ICAM-1 of TNF α activating endothelial cells and prevent the loss of β - catenin of the cells , protect the adherens junctions of endothelials cells .

目的研究乌司他丁和抑肽酶对体外循环（CPB）小儿炎性反应及心肌损伤的影响。

Objective To investigate the effects of two protease inhibitors ( ulinastatin and aprotinin ) on inflammatory response and myocardial injury in children undergoing cardiopulmonary bypass ( CPB ) .

开放60min时抑肽酶组IL-8浓度与开放30min相比无继续升高的趋势（P>005），而对照组仍继续升高（P<005）。

IL-8 in the aprotinin group at 60 minutes did not increase , compared with that at 30 minutes after reperfusion .

再灌注24h和48h后，抑肽酶处理组的神经功能评分均显著高于缺血组（P<0.05）；

The neurological function score in aprotinin treatment group was significantly higher than that in ischemia group at 24 hours and 48 hours after reperfusion ( P < 0.05 ) .

抑肽酶能够显著的降低AQP4表达水平、脑水含量、IL-8含量的水平。

The level of brain water content 、 IL-8 content 、 AQP4 immune expression intensity was decreased and ion content disorder was improved after Aprotinin administration .

α-抗胰蛋白酶组和抑肽酶组的抑制效果虽不及前两组，但分别较对照组减少了20.04%和18.67%（P0.05）。

The inhibition effect of α - antitrypsin group and the aprotinin group is not the same as former two groups and compared with the control group , the concentration still respectively reduced 20.04 % and 18.67 % ( P0.05 ) .

结果再灌注后UTI组动脉血和肺组织中MDA水平、MPO活性较抑肽酶组及对照组低（P<0.05），血清SOD活性较抑肽酶组及对照组高（P<0.05和P<0.01）。

Results The levels of MDA , MPO in sera of venous blood and lung tissue in UTI group were significantly lower than those in aprotinin group and control group ( P < 0.05 ) .

抑肽酶使CPB中ACT略延长，与对照组相比无统计学意义，对肝素用量无影响，24小时胸液减少35%（P＜0.05）。

In the aprotinin group , ACT was slightly prolonged but both ACT and heparin requirements showed no significant differences than the control group . The first 24 hour chest tube drainage was reduced 35 % ( P < 0.05 ) than the control group .

抑肽酶总量成人为400万kIU，儿童为200万kIU。止血芳酸用量为40mg／kg；

To used aprotinin ( 4 000 000 kIU in adult , 2 000 000 kIU in children ) and tranexamic ( total 40 mg / kg );

缺血30min时缺血组波形消失，抑肽酶处理组波幅降下30%。

The waves of ischemia group disappeared at 30 minutes of ischemia , and the waves of aprotinin treatment group reduced to 30 % .