恶病质

目的是建立一种癌性恶病质动物模型，并观察其营养指标和体液因子的变化。

Objective to establish an experimental cancer cachectic model , and observe the nutritional and hormonal disorders .

核因子κB与癌症恶病质骨骼肌萎缩的研究进展

The Research Progress on NF - κ B and Skeletal Muscle Atrophy in Cancer Cachexia

癌症恶病质（cancercachexia）发生于恶性肿瘤晚期。

Cancer cachexia occurs in the late stage of malignant tumor .

同时，对现在住院的患者选择不同辨证分型的恶病质病人检测IL-1、IL-6，TNF-α。

IL-1 , IL-6 , and TNF-ain cachexia patients with different syndromes were examined .

细胞因子IL-1、IL-6和IL-8水平与胃窦癌恶病质关系

Association of cytokine il-1 , il-6 and IL-8 levels with cachexia in patients with antral gastric cancer

实验研究以移植Lewis肺癌诱导小鼠发展为恶病质模型。

In the animal experiments , mice with inoculated Lewis pulmonary carcinoma were used as cachetic model .

大量研究发现，恶病质状态下骨骼肌蛋白降解通过ATP泛素蛋白酶体途径。

In recent years , accumulating evidences suggest that the ATP ubiquitin proteasome pathway may be crucial in muscle cachexia .

利用该动物模型观察沙利度胺对癌症恶病质的治疗作用，以细胞因子（TNF-α和IL-6）为靶点，研究沙利度胺治疗恶病质的作用机制。

To observe the effect of thalidomide on cancer cachexia and research the mechanism in cytokine level ( TNF - α and IL-6 ) .

至第15天，所有荷瘤小鼠去瘤体重较健康组均明显降低（P0.05），即所有荷瘤小鼠均进入恶病质状态。

On the fifteenth day , the mean non-tumor weight in the tumor bearing mice became lower than that in healthy mice ( P0.05 ), all the mice were in condition of cancer cachexia .

目的研究核因子（NF）κB和促炎细胞因子在癌性恶病质形成中的作用以及吲哚美辛（IND）对其调控作用。

Objective To assess the putative involvement of NF κ B and pro inflammatory cytokines in the pathogenesis of cancer cachexia and the therapeutic efficacy of indomethacin ( IND ) on cachexia .

以前在人类神经细胞中发现的一种存活促进肽以及人体内与一种鼠恶病质因子同源的多肽均被证实为DCD衍生肽。

It has been confirmed that a survival-promoting peptide and a human homologous of a mouse cachexia factor reported previously are both DCD-derivative peptides .

320例有伴有恶病质的晚期肿瘤患者在TNA液治疗后，Karnofsky（Kps）计分平均提高了11.6分。

The Karnofsky performance score ( Kps ) of 320 patients with cachexia caused by malignant tumour treated with TNA increased by 11.6 in average .

目的：研究泛素蛋白质酶途径在癌性恶病质小鼠骨骼肌中的表达以及吲哚美辛（IND）对其的调控作用。

Objective : To investigate the expression of ubiquitin-proteasome pathway in skeletal muscle of cachectic mice and the effect of indomethacin ( IND ) on it .

方法建立T739小鼠癌症恶病质模型，观察KLT对模型鼠细胞免疫功能的作用。

METHODS T739 murine model of cancer cachexia was established to observe the effect of KLT on the cellular immunological function of the mouse .

目的：通过分析慢性心力衰竭（HF）恶病质患者血清瘦素（leptin）及肿瘤坏死因子α（TNFα）的浓度变化，探讨其在心源性恶病质发病过程中的可能作用及临床意义。

Objective : To explore the significance of leptin to the pathogenesis of cardiac cachexia according to alteration of serum leptin and TNF - α levels in chronic heart failure patients . Methods : Serum leptin and TNF - α concentration were measured by radioimmunoassay .

目的利用荷瘤动物模型初步探讨癌症恶病质发生机理，评估肿瘤坏死因子抗体（TNF－αAB）及高聚金葡素（BM828）治疗恶病质的疗效。

Objective To evaluate the role of TNF α in the development of cancer cachexia , and the effects of TNF α antibody and high agglutinated staphylococcin ( BM828 ) in the treatment of experimental cancer cachexia .

锌-α2-糖蛋白（ZAG），又名脂肪动员因子，是参与癌性恶病质形成的一种分泌性蛋白，它通过促进机体脂肪分解和增加产热双重途径减少体内脂肪。

Zinc - α 2-glycoprotein ( ZAG ) is identical with a lipid mobilizing factor capable of inducing loss of adipose tissue in cancer cachexia through an increased lipid mobilization and utilization .

癌症恶病质小鼠中，消炎痛治疗组小鼠的体重明显高于生理盐水对照组且生存时间延长（P<0.05），而血清IL1、IL6、TNFα的水平显著低于生理盐水对照组（P<0.05）。

Compared to saline treatment , indomethacin intervention apparently down regulated the levels of IL 1 , IL 6 and TNF α ( P < 0.05 ), and remarkably prolonged the survival of mice ( P < 0.05 ) .

结果癌症恶病质组小鼠血清IL1、IL6、TNFα的水平显著高于健康对照组（P<0.05），而体重明显低于健康对照组（P<0.05）。

Results The mice in cancer cachexia group had significantly higher serum levels of IL 1 , IL 6 and TNF α ( P < 0.05 ) and lower body weight ( P < 0.05 ) than those in healthy control group .

营养支持治疗心力衰竭恶病质的临床观察

The clinical observation of treating cardiac failure cachexia with nutritional support

吲哚美辛对癌性恶病质小鼠肌肉泛素-蛋白质酶途径的影响

Effects of indomethacin on ubiquitin-proteasome pathway in muscles of cancer cachectic mice

癌症恶病质与肿瘤坏死因子关系的临床研究

A Clinical Study of Cachexia and its Relationship to Tumor Necrosis Factor

风湿性心脏病合并恶病质的围手术期营养支持

Perioperative nutritional support of rheumatic heart disease associated cardiac cachexia

合并心脏恶病质瓣膜病的围手术期处理

The Perioperative Management in Valvular Disease Associated with Cardiac Cachexia

扶正合剂治疗肿瘤恶病质60例疗效观察

Clinical observation on treating 60 cases of cancer cachexia with Fuzheng Composition

113例肺癌恶病质发生原因分析

An Analysis of the Cause of Cachexia in 113 Cases with Pulmonary Carcinoma

癌性恶病质的药物治疗与营养支持

The management of cancer cachexin : drug and nutrition

癌性恶病质发病机制及治疗的研究进展

Advances in mechanism and therapy of cancer cachexia Q & A on Sex

癌性恶病质代谢的研究现状

The Present Status of Research on Cancer Cachexia Metabolism

癌症恶病质的发生及治疗的实验研究

Experiments on the Development and Management of Cancerous Cachexia