巴氯芬

研究了巴氯芬与细胞色素C间的结合。巴氯芬能够使细胞色素C发生增色效应。

Explored the combine of baclofen with cytochrome C and found that reactant baclofen could make cytochrome C having a hyperchromic effect .

红外光谱结果表明巴氯芬及γ-氨基丁酸对细胞色素C的二级结构产生了影响，而使细胞色素C的结构松散。

The secondary structure of cytochrome C have been influenced by both baclofen and γ - aminobutyric acid and then loosen its structure .

继而，左旋巴氯芬抑制场电位作用强于GABA。

Baclofen was more effective in inhibiting field potentials than GABA .

巴氯芬对大鼠新鲜分离DRG细胞异四氢烟酸及蝇蕈醇激活电流的抑制作用

Inhibitory Effects of Baclofen on Isoguvacine - and Muscimol-activated Currents in the Neurons Freshly Isolated from Rat DRG

巴氯芬合成中Hofmann重排反应的改进

Improved Hofmann rearrangement in baclofen synthesis

影响巴氯芬缓解脑源性肌痉挛效果的原因分析

Cause analysis of weakening Baclofen effect in treating brain-derived muscular spasm

巴氯芬联合综合康复疗法治疗偏瘫肌痉挛的临床疗效分析

The clinical effect on hemiplegic muscle spasticity with Baclofen treatment plus comprehensive rehabilitation therapy

过量巴氯芬导致的酷似脑死亡的昏迷

Coma mimicking brain death following baclofen overdose

观测到巴氯芬使胃蛋白酶的最大紫外吸收峰蓝移。

Baclofen caused the blue shift of the maximum of UV absorption peak of pepsin .

目的观察巴氯芬对脑血管疾病后肌张力增高的改善，从而反映其对脑血管病后早期康复的作用。

Objective To explore the effect of Baclofen on the muscular tension after the cerebrovascular diseases .

采用荧光光谱法和紫外可见吸收光谱法研究了巴氯芬与胃蛋白酶的结合。

The binding interaction between baclofen and pepsin was studied by ultraviolet absorption and fluorescence spectra .

鞘内注射吗啡联合巴氯芬对切口痛大鼠脊髓兴奋性氨基酸含量的影响

Effect of intrathecal injection of morphine and baclofen on contents of spinal excitatory amino acids in rat model of incisional pain

鞘内注射巴氯芬被证明是优于从基线的痉挛阿什沃思等级和频率变化的痉挛安慰剂。

Intrathecal baclofen was shown to be superior to placebo in the change from baseline in the Ashworth rating of spasticity and the frequency of spasms .

通过红外光谱法表征可得，巴氯芬和γ-氨基丁酸都能够改变牛血清白蛋白的二级结构。

Measured by the FT-IR spectroscopy , it was the result that both baclofen and γ - aminobutyric acid could change the secondary structure of BSA .

用红外光谱法研究了巴氯芬对胃蛋白酶的影响，结果表明，巴氯芬改变了胃蛋白酶的二级结构。

FT-IR spectroscopy was used to investigate the effect of baclofen on pepsin . The results showed that the secondary structure of pepsin has been changed by baclofen .

根据非辐射能量转移理论，胃蛋白酶与巴氯芬之间发生了能量转移，从而使胃蛋白酶发生了荧光猝灭。

Meanwhile , according to the non-radiation energy transfer theory , there is a energy transferring between pepsin and baclofen , so the fluorescence intensity of pepsin was quenched .

荧光光谱法和紫外光谱法研究表明：巴氯芬与牛血清白蛋白结合的结合不属于非辐射共振能量转移。

Being improved by fluorescence spectra and UV spectra , we are assured that the binding interactions between baclofen and BSA were not belonging to the unradioactive resonate energy transfer .

目的：分析影响巴氯芬缓解脑源性肌痉挛效果的原因，探讨巴氯芬应用中的注意事项。

AIM : To analyze the cause of weakening Baclofen effect in treating brain derived muscular spasm and explore what we should pay attention to in the application of Baclofen .

巴氯芬是γ-氨基丁酸的脂溶性衍生物，属于神经递质类药物。主要用于骨骼肌松驰，解痉挛及外伤等。

Baclofen belongs to the neurotransmitter pharmaceutical , which is the fat-soluble derivate of γ - aminobutyric acid and it always been adopted in the cure of relaxation of skeletal muscle , hyperkinesias and some traumatic injuries .

利用胃蛋白酶的催化性质研究巴氯芬对胃蛋白酶活性的影响，结果表明，巴氯芬抑制了胃蛋白酶46.50%的活性。

Took advantage of the catalysis of pepsin , a study on the influence of baclofen to pepsin had been carried out , with its result showed that reactant baclofen restrained the activity of pepsin for about 46.50 % . 4 .