卡巴胆碱

卡巴胆碱对LPS刺激外周血白细胞释放TNFα的影响

Effect of carbachol on TNF α release from peripheral blood leukocytes stimulated by lipopolysaccharide

结论：①淀粉样β蛋白降低基础肌醇1,4,5-三磷酸的含量，并能抑制卡巴胆碱及KCl诱发的肌醇1,4,5-三磷酸的生物合成。

CONCLUSION : 1 β - amyloid protein can reduce basal contents of inositol 1 , 4 , 5-trisphosphate and inhibit carbachol and KCl-induced synthesis of inositol 1 , 4 , 5-trisphosphate .

蛋白激酶C激动剂可以抑制上述反应，提示介导卡巴胆碱诱发钙离子稳态变化的毒蕈碱样胆碱能受体可以被PKC负性调节。

PKC agonist could inhibit the responses indicating that muscarinic receptors mediating the carbachol-induced intracellular calcium mobilization were negatively regulated by intracellular PKC .

2.17p-雌二醇对卡巴胆碱所引起的去卵巢SD大鼠离体小肠平滑肌张力升高起到抑制作用，与浓度呈正相关，这种抑制可被受体拮抗剂氟维司群所消除。

In vitro 17 β - estradiol could inhibit the contraction tension enhancement of small intestine smooth muscles pieces from ovariectomized SD rats caused by carbachol , moreover the effect was correlated with the concentration of 17p-estradiol . This inhibition could be eliminated by Fulvestrant . 3 .

肠道缺血期给予卡巴胆碱后，血浆内ALT、SCr、CK-MB和TNF-α水平显著降低（P均<0.05），术后24~72h心、肺、肝、小肠病理学损伤明显减轻。

While in carbachol treatment groups , the levels of TNF - a , Cr , ALT , CK - MB in plasma were decreased dramatically after enteral administration of carbachol during ischemia stage . The pathological injuries were alleviated in the heart , liver , and kidney .

卡巴胆碱对烧创伤后肠道功能障碍影响的研究

Influence of carbachol on intestinal dysfunction after traumatic or burn injury

卡巴胆碱对内毒素刺激大鼠腹腔巨噬细胞炎症细胞因子表达的影响

Effects of carbachol on inflammatory cytokines expression of rat abdominal macrophages stimulated by lipopolysaccharide

卡巴胆碱对小鼠多器官功能障碍综合征早期树突细胞作用的研究

Effects of carbachol on the splenic dendritic cells in early stage of MODS in mice

卡巴胆碱对脓毒症大鼠小肠组织含水率和促炎症因子水平的影响

Effects of carbachol on intestinal proinflammatory factors and tissue water content in rats with sepsis

卡巴胆碱治疗创伤和感染后胃肠功能障碍78例

Treatment of severe trauma-or infection-induced gastrointestinal dysfunction with carbachol : an analysis of 78 cases

卡巴胆碱对脓毒症大鼠肠组织缺血和氧自由基损伤的保护作用

The protective effect of carbachol against intestinal ischemia and free radical injury in rats with sepsis

卡巴胆碱干预大鼠腹腔粘连的作用及机制研究

Study on the Effects of Carbachol on the Postoperative Intra-abdominal Adhesions and Its Mechanism in Rat

卡巴胆碱治疗感染后胃肠功能障碍患者的临床随机对照研究

Effect of carbachol on gastrointestinal dysfunction in patients with serious infection : a randomized controlled clinical trial

卡巴胆碱可抑制肠缺血引起的外周血淋巴细胞凋亡率的增加，但增加中性粒细胞的凋亡率。

Carbachol could reduce the apoptosis rate of lymphocytes , but enhance that of neutrophils after gut ischemia .

该工艺以氯化胆碱为原料，经三光气酰氯化，氨化反应制得卡巴胆碱。

This process use choline chloride as raw material to get carbachol through triphosgene acyl chlorination reaction and amination .

卡巴胆碱对50%TBSA烧伤犬口服补液时组织灌流和脏器功能的影响

Effect of carbachol on splanchnic perfusion and organ function during oral fluid resuscitation in 50 % TBSA full-thickness burn in dogs

卡巴胆碱对大鼠腹腔粘连形成和粘连组织TGF-β1表达的影响

Effect of carbachol on formation of intra-abdominal adhesions and expression of transforming growth factor - β _1 in adhesions tissues in rats

卡巴胆碱对肠部分缺血-再灌注损伤所致全身炎症反应和多器官功能障碍的影响

Enteral administration of carbachol on systemic inflammatory response and multiple organ dysfunction induced by partial ischemia / reperfusion injury to the gut

卡巴胆碱对肠缺血-再灌注大鼠外周血白细胞凋亡及细胞因子表达的影响

Effects of carbachol on apoptosis of peripheral white blood cells and expression of cytokines in rats suffering from gut ischemia / reperfusion injury

曲伏前列腺素和卡巴胆碱对白内障术后眼压的影响卡巴胆碱对大鼠40%失血口服补液时胃排空和胃血流量的影响

Effects of carbachol on gastric emptying and gastric blood flow in the oral fluid resuscitation of 40 % blood volume loss in rats

结论：卡巴胆碱能减轻缺血再灌注大鼠肠道局部炎症反应，机制可能与其对抗致炎因子的作用有关。

Conclusion : The results suggest that carbachol could alleviate gut inflammatory response during gut ischemia / reperfusion injury by inhibiting proinflammatory cytokine release .

目的：研究拟胆碱药卡巴胆碱对缺血再灌注肠道局部炎症反应的影响及意义。

Objective : To investigate the effects of carbachol on local inflammation in gut tissue during ischemia / reperfusion ( I / R ) .

目的研究卡巴胆碱对失血性休克口服补液时胃排空和胃血流量的影响。

Objective To investigate the effects of carbachol on gastric emptying and muscosal blood flow with dogs in oral fluid resuscitation of hemorrhagic shock .

目的研究烫伤休克大鼠肠内补液时给予卡巴胆碱对肠血管通透性及组织水肿的影响。

Objective To investigate the effects of carbachol on intestinal vascular permeability and tissue edema with enteral glucose ? electrolyte solution ( GES ) resuscitation in scald shock rats .

目的观察肠道内给予卡巴胆碱对兔肠部分缺血再灌注（I/R）损伤及重度烧伤患者肠道功能障碍的影响。

Objective To investigate the influence of enteral administration of carbachol on the intes - tinal dysfunction of both severely burn patients and rabbits with partial intestinal ischemia / reperfusion ( I / R ) injury .