嵌合病毒

嵌合病毒技术在黄热病毒属病毒研究中的应用

The application of chimeric virus in research on the Flavivirus

脊髓灰质炎I型/柯萨奇B3型嵌合病毒基因的构建及其生物学特性的初步研究

Poliovirus I / Coxsackievirus B3 Chimeric Gene : The Construction and Primary Research of Its Biological Character

三重融合PCR法构建感染性辛德毕斯嵌合病毒cDNA克隆

Construction of Infectious Chimeric cDNA Clone of Sindbis Virus by Triple Fusion PCR

用此SHIV原病毒DNA转染293T细胞，细胞中能够检测到嵌合病毒基因的转录与翻译；

The gene expression of chimeric virus could be detected in 293T cells transfected by SHIV proviral DNA .

在艾滋病的相关研究中，各种SHIV嵌合病毒及其动物感染模型得到了广泛的应用。

Various chimeric SHIVs and their animal models have been widely used in AIDS research .

BIV/HIV嵌合病毒的构建与活性分析

Construction and Characterization of Chimeric BIV / HIV

然后取不同的时间点来验证病毒的增殖趋势，发现嵌合病毒在早期的增殖能力也明显的低于亲本病毒。

Then we observed the proliferation trends in different time , the proliferation in BHV-5 was lower than parental virus in early times .

同时，为了研制新型的AIDS疫苗，本文也介绍了甲型减毒嵌合流感病毒诱导HIV-1广谱中和抗体的分子机制。

At the same time , in efforts to develop AIDS vaccine components , we also introduced the molecule mechanism that live attenuated influenza A virus as vector elicited broadly neutralizing antibody of HIV-1.1 .

阴道毛滴虫核酶嵌合型病毒载体FRzS的构建

Construction of TV Hammerhead Ribozyme Mosaicism Virus Transfer Vector FRzS

SG511是E1855KD区缺失的嵌合型溶瘤病毒，此病毒克服了以前需要依赖肿瘤细胞表面CAR高表达的局限性，特异性的针对P53缺失或者突变的肿瘤细胞，而对正常细胞没有影响。

This virus overcome the limitation that are necessarily dependent on high expression of CAR on cancer cell surface , and specially target on P53 deficient or any mutant cancer cell , while have no cytotoxic effect on those normal cells .

中国HIV-1B亚型P55和嵌合的P55-V3病毒样颗粒候选疫苗免疫效果的研究

Immunogenicity Study of P55 and Chimeric P55-V3 Virus-like Particles of Chinese Strain of HIV-1 Subtype B

其机理除了应用免疫抑制治疗所带来的后果外，也不能忽视移植术本身带来的影响，如癌基因嵌合、致癌病毒的转移等。

Besides the outcome of immunosuppression , the effects of transplantation itself , such as oncogene chimera , transition of carcinogenic virus and so on , can not be neglected .

嵌合人牛免疫缺陷病毒cDNA的构建及其在MT4细胞中的活性分析

Construction and analysis of activity of an HIV-1 / bovine immunodeficiency virus chimeric clone cDNA