崩解剂

【方法】以自制吸水装置考察三种崩解剂的吸水性能；制备了一系列不同磺化度的SPES膜，测试了膜的接触角、含水率和电导率。

[ Method ] : The hygroscopicity of disintegrants was measured by a self-made apparatus for measurement of water uptake . Membrane properties were characterized with contact angle , water uptake and conductivity .

在片芯处方筛选方面，考察了崩解剂、填充剂、润滑剂的影响，最终确定采用CMS-Na为崩解剂。

Screening prescription of the core tablets , we study the Influence of disintegrants , fillers , lubricants , and ultimately determine to use the CMS-Na disintegrant .

用途：本品主要用作药物固体制剂，全粉末直接压片的干燥粘合剂，胶囊填充剂，崩解剂，湿法造粒粘合剂和着色的延展剂。

Use : That is a padhesive with the powder Diecty , Compress tablets and replenisher , Disinteante , adhesive of the capsula .

采用半干法合成片剂崩解剂校甲基淀粉（CMS）；

Carboxymethylstarch ( CMS ) tablets disintegrant was synthesized with hemi-dry process .

采用淤浆法新工艺制备了药剂辅料用羧甲基纤维素钙（CaCMC），并与常用崩解剂、根据其它方法制备的CaCMC进行了比较。

Carboxymethylcellulose calcium for pharmaceutical necessities is prepared by slurry process . Compared with other disintegration agents , the present Ca_CMC has quicker disintegration rate .

目的：对国产交联聚维酮（PVPP）用作片剂崩解剂初步评价。

OBJECTIVE : To estimate domestic PVPP as a tablet disintegrant .

国产PVPP用作片剂崩解剂的初步评价

Preliminary estimation of domestic PVPP as a tablet disintegrant

方法以PVPP为崩解剂、MCC为填充剂、CMCCa为溶胀性辅料、1%HPMC水溶液为粘合剂，制备麝香保心分散片；

Methods Heart protecting musk dispersible tablets were prepared by selecting PVPP as disintegration , MCC as filler , CMC Ca as sweller and 1 % HPMC solution as adhesive agent .

本文叙述了羧甲基淀粉（Carboxymethylstarch；CMS）中H/Na比值的改变对崩解剂CMS的吸水溶胀性能和崩解性能的影响。

The effect of the change of H / Na ratio in disintegrator Carboxymethyl Starch ( CMS ) on its functions such as of water-absorbing , swelling and disintegrating had been described in this article .

采用L9（3~3）正交表设计实验，对崩解剂的用量、MCC的用量、压片硬度等因素进行考察，优选出口崩片的基本处方。

Through the orthogonal experiment design , selected the basic formulation of ODT by studying the content of super-disintegrant , the content of MCC and the consistency of the tablets .

作为新型辅料，MCC不仅可以作为崩解剂，而且还可作为粘合、稀释剂使用；而CCMC-Na是一种超级崩解剂。

As new material , MCC not only used as disintegrating agent , but also used as adhesive and diluent . CCMC-Na is used as super disintegrant .

结论：AvicelPH102微晶纤维素和40～80目乳糖作为主要稀释剂可用于粉末直接压片工艺。PVPPXL是一种优良的超级崩解剂。

Conclusion : Microcrystalline cellulose ( Avicel PH102 ) and lactose ( 40 ~ 80 meshes ) are better candidates as major diluents in direct compression and PVPP XL as an excellent disintegrant .

崩解剂羧甲基淀粉干（半干）法合成及性能研究

Influence of Synthetic Processes for Disintegrant Carboxymethyl Starch and its Performance

应用单因素实验选择使用不同的崩解剂和赋形剂以确保最佳崩解。

Different disintegrants and excipients were decided by single factor test .

应用范围：在药剂中主要用作崩解剂。

Applications : Mainly used in the pharmaceutical disintegrating agent .

新型崩解剂钠基膨润土在阿司匹林口服片剂中的应用研究

Study on Sodium Bentonite Used as Disintegrant to Aspirin Tablets

介绍了羧甲基淀粉的制备方法与工艺及其做为崩解剂在各种药物中的应用。

The product can be used as disintegrating agent in many fields of medicine .

目的：研究崩解剂交联聚维酮对对乙酰氨酚片溶出度的影响。

OBJECTIVE : To study crospovidone effect on the dissolution rate of paracetamol tablets .

药用小麦羧甲基淀粉崩解剂的合成及性能

Synthesis and Properties of Medical Wheat Carboxymethyl Starch

目的优选雷公藤多苷分散片的崩解剂，并考察其成品的质量。

Objective To optimize the disintegrating agent from Tripterygium Glucosides dispersible tablet and study its quality .

超强药片崩解剂羧甲基淀粉的合成

Synthesis of Tables Disintegrant Carboxymethyl Starch

结果：确定了以羧甲基淀粉钠、交联聚乙烯吡咯烷酮作为崩解剂的分散片处方；

RESULTS : Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula ;

测定了以羧甲淀粉钠为崩解剂的菲牛蛭提取物肠溶胶囊的体外释放。

In vitro release of enteric capsules of Poecilobdella manillensis Lesson extract using sodium carboxy-methyl starch as disintegrant was investigated .

结论：改用羧甲基淀粉纳、液体石蜡为崩解剂效果好，保证了药品质量。

Conclusion : Take Sodium carboxymethylation and liquid paraffin as disintegration preparation are more available and can im-prove the medicine quality .

方法：经多次试验，我们采用了针对土霉素作用效能更好的崩解剂&羧甲基淀粉钠、液体石蜡进行试验。

Method : After several experiments , we take Sodium carboxymethylation and liquid paraffin as better disintegration preparation to do experiment .

结论：崩解剂以及片剂的吸水滞后时间是影响片剂崩解效果的主要因素之一。

CONCLUSION : The lag time of water uptake of disintegrants of tablets could be helpful in evaluating disintegrated effect of disintegrants .

结论：3%交联羧甲基纤维素钠作崩解剂使于氏萎胃宁浓缩丸崩解时间符合药典规定。

Conclusion : The disintegrating time of Yushi Weiweining concentrated pill accords with The Chinese Pharmacopoeia when CCNa is used in3 % .

方法：分别考察稀释剂、崩解剂、黏合剂及包衣对氯沙坦钾片溶出度的影响。

METHODS The effects of diluents , disintegrants , bonding agents and coating process on the dissolution profile of the losartan potassium tablets were studied .

结果：崩解剂、润滑剂的种类、用量、压片的压力等对分散片的质量有影响。

Results : The types , dosage and the pressure of preparations and so on had something to do with the quality of dispersible tablets .

研究几种新型崩解剂在阿奇霉素分散片中的作用，考察颗粒流动性、片剂崩解时限等质量控制指标，确定分散片中几种崩解剂的最佳用量。

These combined disintegrants were selected to obtain the best dosage of azithromycin dispersible tablets according to the fluidity of the granules and the disintegration of tablets .