吉西他滨

葫芦素B与吉西他滨联合应用对胰腺癌的抑制作用及其机理研究

Combined Inhibitory Effect of Cucurbitacin B and Gemcitabine in Pancreatic Cancer

吉西他滨是一种嘧啶类似物，通过干扰细胞DNA的合成与修复达到抑制肿瘤细胞生长、诱导凋亡的作用。

Gemcitabine is a pyrimidine analogs , which can inhibited tumor cell growth and inducted apoptosis by interfering with DNA synthesis and repair .

DNA断裂电泳可见典型的梯形DNA条带，大小约180~200bp的整倍数递增，随吉西他滨作用时间延长和浓度的增加而逐渐增强；

DNA ladder could be demonstrated on DNA electrophoresis and its intensity was increased with the increased concentration and prolonged time of gemcitabine .

p53正向凋亡调控因子在吉西他滨诱导胰腺癌细胞凋亡过程中的作用

Role of p53 up-regulated modulator of apoptosis in gemcitabine-induced apoptosis of human pancreatic cancer cell lines

吉西他滨治疗复发性卵巢癌的Meta分析

A Meta Analysis of Gemcitabine for Recurrent Ovarian Cancer

关于晚期胰腺癌的Meta分析：吉西他滨联合化疗与吉西他滨单药

Comparing Gemcitabine-based Combination Chemotherapy with Gemcitabine Alone in Inoperable Pancreatic Cancer : A Meta-analysis

盐酸吉西他滨对K562细胞增殖、凋亡及bcr/AblmRNA表达的影响

Effects of Gemcitabine on Proliferation , Apoptosis and Expression of bcr / abl Fusion Gene mRNA in K562 Cells

贝伐单抗联合吉西他滨的治疗的II期试验结果为吉西他滨-厄洛替尼联合贝伐单抗或安慰剂治疗的III期试验提供了理论基础。

Phase II results for bevacizumab plus gemcitabine provided the rationale for a phase III trial of gemcitabine-erlotinib plus bevacizumab or placebo .

吉西他滨联合外照射诱导人乳腺癌MCF-7细胞凋亡

Apoptosis of breast cancer cell line MCF-7 cells induced by gemcitabine and radiation

一项最新的III期试验显示吉西他滨联合厄罗替尼布可以显著延长生存期。

A recent phase III trial of the combination of gemcitabine with erlotinib was associated with a significant prolongation of survival .

靶向Survivin的siRNA对胰腺癌细胞增殖及对吉西他滨化疗敏感性影响

Effects of Survivin siRNA on Proliferation of Human Pancreatic Cancer Cells and Chemosensitivity to Gemcitabine

评价吉西他滨对曾接受治疗的宫颈非鳞状细胞癌患者的疗效：一项妇科肿瘤人群的II期临床研究

Evaluation of gemcitabine in previously treated patients with non-squam ous cell carcinoma of the cervix : A phase II study of the Gynecologic Oncology Group

结论吉西他滨联合铂类化疗药物是治疗晚期NSCLC安全、有效的联合化疗方案，值得临床进一步研究。

Conclusions Gemcitabine plus cisplatin or carboplatin chemotherapy is safe and effective for patients with advanced NSCLC .

非小细胞性肺癌用GP方案吉西他滨（GEM）1000mg/m2，第1天和第8天静脉注射；

GP adopted to non-small lung cancer . GEM 1000 mg / m2 , intravenously at the first day and eighth ;

本研究旨在观察国产吉西他滨（gemcitabine，GEM）与顺铂（cisplatin，DDP）联合化疗方案治疗晚期非小细胞肺癌的临床疗效及毒副反应。

This study is to observe the clinical effect and toxicity of combination of gemcitabine with cisplatin for advanced NSCLC .

采用吉西他滨和CD40抗体治疗后，30%的小鼠肿瘤瘤体缩小。

After treatment with gemcitabine and CD40 antibody , the tumors shrank in30 % of the animals .

结果与对照组比较，25mg/kg和50mg/kg的单剂量吉西他滨都对Lewis实体瘤生长有抑制作用（P<0.05）；

Results Single dose of 25mg / kg or 50mg / kg of gemcitabine had significant inhibiting effect on the growth of Lewis tumor .

Govindarajan解释说，目前最常见的胰腺癌治疗药物是吉西他滨，这个药物通过进入肿瘤细胞DNA并抑制DNA复制来发挥抗癌作用。

The drug most commonly used to treat pancreatic cancer is called gemcitabine and works by entering into the DNA of cancer cells and stopping replication .

IP-10基因治疗联合吉西他滨抗肿瘤实验研究

Anti-tumor Effects of Interferon-inducible Protein 10 Gene Therapy Combined with Gemcitabine

方法51例中晚期胰腺癌，其中25例采用经动脉持续灌注吉西他滨和5-Fu方案，26例采用经外周静脉灌注吉西他滨和5-Fu方案。

Methods Of 51 advanced pancreatic carcinoma patients , 25 received gemcitabine combined with 5-fluorouracil via transarterial continuous infusion chemotherapy ( group A ) .

目的：研究吉西他滨（Gemcitabine）加卡铂（Carboplatin）联合化疗在治疗后局部未控的晚期鼻咽癌病人中使用的效果。

Objective : To observe the value and results in treatment of uncontrolled advanced nasopharyngeal cancer with Gemcitabine and Carboplatin combination .

化疗是中晚期胰腺癌的主要治疗方法，其中吉西他滨已被美国FDA批准应用于胰腺癌的一线化疗。

Chemotherapy is the main treatment for advanced pancreatic cancer and gemcitabine has been approved by the FDA as firs-line agents for the treatment of pancreatic cancer .

目的：评价国产药与进口药盐酸吉西他滨治疗非小细胞肺癌（NSCLC）的疗效、安全性及不良反应。

Objective : To evaluate the curative effect , safety and adverse reaction of domestic and imported gemcitabine hydrochloride in non-small cell lung cancer ( NSCLC ) .

目的观察国产吉西他滨（GEM）联合顺铂（DDP）治疗复发性乳腺癌的疗效及毒副作用。

Objective To evaluate the efficacy and toxicity of combined chemotherapy with gemcitabine ( GEM ) plus cisplatin ( DDP ) in the treatment of recurrent breast cancer .

紫杉醇和吉西他滨对鼻咽癌HNE2细胞系协同放射增敏的作用

The Synergistic Radiosensitization of Paclitaxel and Gemcitabine on Nasopharyngeal Carcinoma Cell line HNE_2

目的：观察吉西他滨（GEM）、氟尿嘧啶（5FU）及顺铂（DDP）三药联合化疗对晚期胰腺癌的客观疗效及其临床受益反应（CBR）。

Purpose : To observe the curative effect and the clinical-benefit-response of patients with advanced pancreatic cancer who used a combine of Gemcitabine , 5-FU and PDD .

目的探讨放射性125I粒子植入联合吉西他滨治疗进展期胰腺癌的临床价值。

[ Objective ] To explore the significance of implanted 125I radioactive particles into tumor combined with gemcitabine to treat extended local pancreas cancer .

目的：观察和评价吉西他滨（GEM）联合长春瑞滨（NVB）治疗晚期非小细胞肺癌（NSCLC）的疗效和毒性。

Objective : To evaluate clinical efficacy and toxicity of gemcitabine ( GEM ) combined with navelbine ( NVB ) for stage ⅳ non-small cell lung cancer ( NSCLC ) .

目的：比较放射性I125粒子和I125+吉西他滨（gemcitabine，GEM）在治疗局部进展期胰腺癌中的作用。

Objective : To study the role of I125 and I125 plus gemcitabine ( GEM ) in the treatment of unresectable carcinoma of the pancrease .

吉西他滨诱导胰腺癌细胞株SW1990的耐药作用与硫氧还蛋白还原酶活性改变的观察

Induced Drug Resistance and Explored the Changes of the Activity of Thioredoxin Reductase in Pancreatic Cancer Cell Line