内源性物质

Ghrelin是目前为止除了生长激素释放激素和生长抑素外，第二个调节GH分泌的内源性物质。

Ghrelin is at present except that the growth hormone release hormone , endogenous material that the second regulation GH secreted .

磷脂和胆固醇均为人体内源性物质，对人体无毒无害，已经被FDA批准为药用辅料，目前已有抗真菌药两性霉素B脂质体上市应用于临床。

Phospholipids and cholesterol are endogenous substances and non-toxic to human , they have been approved as medicinal materials by FDA , and there is liposomal amphotericin B used in clinic as antifungal agents .

CYP2J就是这样一种主要代谢内源性物质花生四烯酸的细胞色素酶P450超家族。

Among such Cytochrome P450 enzymes , CYP2J2 mainly metabolizing arachidonic acids into epoxyeicosatrienoic acids , was detected recently in human beings .

API-MS离子化规律及LC-MS联用技术在药物和内源性物质代谢中的应用研究

Ionization Regulation of API-MS and Application Studies on LC-MS Hyphenated Technique in the Metabolism of Drugs and Endogenous Substances

特别时近年来，API质谱与色谱的成功联用，这种技术越来越广泛被用在药物代谢和内源性物质的分析中，使微量成分的分析成为可能。

Recently , the API-MS has been successfully hyphenated with HPLC , this kind of technique is used widely in drugs , metabolites , and endogenous substances , which makes trace analysis of the composition of medicinal samples become possible .

结果：PAS，AcPAS和内标化合物在生物样本中的测定不受内源性物质干扰。

Results : No endogenous fluorescent interferences were observed during the measurement of PAS , AcPAS and internal standard compound in bio-samples .

结果测定条件下OND基本达到基线分离，大鼠血浆样品测定不受内源性物质干扰。

RESULTS Two enantiomers were separated at baseline level under the determination conditions . The determination was not interfered by endogenous components from rats .

主动转运似乎只限于其结构类似于机体内源性物质的那些药物。

Active transport appears to be limited to drugs structurally similar to endogenous substances .

血浆中内源性物质对样品测定无干扰。

The endogenous substance in plasma did not interfere with the determination of the samples .

针刺预处理可通过调控内源性物质的表达对缺血缺氧心肌组织起保护作用。

Acupuncture preconditioning can protect ischemic and hypoxia cardiac muscle tissue by controlling endogenous substances .

结果：茴三硫与人血浆中的内源性物质完全分离且无其他干扰，保留时间约为3.7min。

Results : Anethole trithione was completely separated from the impurity , the retention time was 3.7 min.

结论：甲胎蛋白是促进某些新生细胞或肿瘤细胞增殖的内源性物质。

Conclusion : AFP could be an endogenous substance which can enhance the proliferation of some neoplastic or tumor cells .

结果39种药毒物可同时从尿中提出，内源性物质不干扰测定。

Results 39 drugs could be determined simultaneously in urine , which was not influenced by intrinsic substances in the sample .

这是由于氨基葡萄糖作为一种内源性物质可以迅速地被用于其它成分的生物合成。

Because it is an endogenous substance which is rapidly utilized by the body for the biosynthesis of other normal constituents .

结果：本文所建立的血浆样品中甲氯噻嗪液质联用色谱测定方法，血浆内源性物质不干扰样品峰，相对回收率为93.7%～105.4%；

Result : In this method , the endogenous factors do not disturb the determination . Method recovery of Methyclothiazide is 93.7 % ~ 105.4 % .

但胆酸作为内源性物质，在3小时产生双峰现象，这可能是由于体内代偿性胆酸分泌所致。

Because it is endogenous substance cholic acid and hyodeoxycholic acid forms two-humped phenomenon , which results from compensated cholic acid secreted in the body . 2 .

蛋白多肽类药物由于其在生物体内含量低、半衰期短和易受内源性物质干扰等特点而使其体内动力学的研究面临很多挑战。

Kinetics studies of protein polypeptide drugs face many challenges because of their low content in organisms , short half-life and vulnerability to interference by endogenous substances .

其作用机制可能有：1、促进内源性物质的释放，减轻氧自由基的氧化损伤；2、减轻心肌梗死面积，减少心肌酶的释放。

Its mechanism may be : 1 、 promote the release of endogenous substances , reduce oxidative damage of oxygen free radicals . 2 、 reduce myocardial infarct area and the release of enzymes .

手性药物因其不同对映异构体在体内的吸收转运、分布、起效、代谢和排泄的过程中均可能对内源性物质有不同甚至相反的作用而成为药物开发领域的一个研究热点。

Chiral drugs has been a research hotspot in drug development field because its different enantiomer may possess different pharmacodynamic and pharmacokinetics effects in absorption , translocation , effect , metabolism and excretion process because there are chiral locus in most endogenous substance .

甾体激素是在研究哺乳动物内分泌系统时发现的内源性物质，具有极重要的医药价值，在维持生命、调节性功能、机体发育、免疫调节、皮肤疾病治疗及生育控制方面有明确的作用。

Steroid was discovered in the investigation of endocrine in the mammal , which has very important value in the medication , such as : maintaining life , adjusting Sex Hormones , growth of human body , adjusting the immune system , treatment for skin diseases and contraception .

内源性活性物质一氧化氮（NitricOXide，NO）的发现，是20世纪80年代生命科学的一大突破性进展。

The discovery of endogenous active substance nitric oxide ( NO ) is a great progress of life science research in the 1980s .

近来研究提示物质依赖戒断后焦虑产生的神经生物学机制与内源性焦虑物质&苯甲二氮卓结合抑制因子（DBI）密切相关。

Current study proves the diazepam binding inhibitor involved in the mechanism for anxiety after drug withdrawal .

精氨酸加压素（argininevasopressin，AVP）也是一种内源性解热物质，它通过作用于VSA的受体而发挥解热作用。

Arginine vasopressin ( AVP ) is another endogenous fever - reduced peptide , which may acted its antipyretic effect by combining with VSA receptor .

以上实验结果提示，脑缺血状态下热应激的保护作用可能是通过激活信号蛋白CREB进而促进内源性保护物质CGRP释放而实现。

The results indicate that heat stress can induce CGRP excretion through CREB signal pathway and thus to exert protective roles for hippocampal neurons under ischemic condition .

红细胞抗高血压因子（AHF）是从人的红细胞中提取出来的一种新的内源性降压物质，其降低血压作用可能是通过刺激血管内皮细胞产生一氧化氮来实现的。

Endogenous antihypertensive factor ( AHF ) is one extraed from human erythrocytes AHF may stimulate the endothelial cell to release nitric oxide ( NO ), which mediates vasodilation , i.d.

电针预处理与艾灸预处理可以增加MIRI兔血清中内源性保护物质NO、NOS及腺苷的释放，诱导心肌保护蛋白HSPs的表达。

Electric acupuncture pretreatment and moxibustion pretreatment can increase the release of endogenous protection materials in serum of MIRI rabbits such as NO , NOS and adenosine , and induce the expression of myocardial protection protein HSPs ; 3 .

因此，在生理和病理条件下，DCN作为脑微血管内皮细胞特异地内源性活性物质具有抗粘附，降低内皮细胞的通透性，抑制炎症反应，对维持内皮完整性发挥重要作用。

In physiological and pathological conditions , DCN , as an endogenous active substance , played a vital role in the maintenance of endothelial integrity by the functions of anti-adhesion , induction of endothelial cell permeability and inhibition inflammatory reaction .

目的观察电针内关对心肌缺血再灌注损伤心肌肌酸激酶（Creatinekinase，CK）和内源性保护物质腺苷的影响，探讨电针内关对心肌缺血再灌注损伤的保护作用及机制。

Objective To investigate the protective mechanism of electroacupuncture at Neiguan point on myocardial cells of myocardial ischemia and reperfusion injury models of rats to see its relations to creatine kinase ( CK ) and Adenosine ( Ado ) which are endogenetic protective material after myocardial ischemia and reperfusion injury .

大鼠心脏预处理后产生的内源性保护物质的研究

Study on endo protective materials produced in heart of rats by

神经递质可同其它内源性活性物质相互作用。

There is interactions of some neurotransmitters with other endogenous active substances .