内源性介质

目的由血红素氧合酶（HO）催化血红素分解代谢而形成的一氧化碳（CO）可能作为一种新的内源性介质参与感染性休克一系列病理生理过程。

Objective Endogenous carbon monoxide ( CO ), which was mainly produced through the metabolism of heme catalysed by hemeoxygenase ( HO ), was suggested to play a role in the pathophysiology of septic shock .

TNF-αmRNA在肺组织中的表达增加，提示内源性炎症介质在继发性肺损伤的发生、发展过程中发挥重要作用。

Increasing of TNF - a mRNA expression in both lungs indicated that endogenous inflammatory mediator played an important role in development of secondary lung injury .

由于内毒素（LPS）是常见的致炎物质，组织胺则是内源性炎症介质，两者均可导致微血管内皮细胞通透性升高，但两者作用存在较大差异。

Lipopolysaccharide ( LPS ) and histamine , the common inflammation-inducing substances and endogenous pro-inflammatory mediator respectively , can result in increased vascular permeability , but there is a difference in their regulating effects .

结论：兴奋诱导性癫痫发作过程中内源性NO介质的变化可能具有重要的抗发作作用。

Conclusion : The endogenous NO ( NO or NO derivatives ) mediators may play an important role against excitotoxin induced seizures in rats .