克霉唑

两性霉素B和制霉菌素、酮康唑和克霉唑都是已知的作用机制类似的抗真菌药物。

Amphotericin B and nystatin , ketoconazole and clotrimazole have been known to have similar antifungal mechanism respectively .

本文报道pH指示剂吸收度比值法测定克霉唑的含量。该法采用指示剂为稀溴酚蓝，测定波长433nm和599nm；

The pH indicator absorbance ratio method was applied to the quantitative determination of clotrimazole .

HPLC测定复方硫酸新霉素口腔溃疡药膜中克霉唑的含量

Determination of clotrimazole in Compound neomycin sulfate oral ulcer pellicles by HPLC

HPLC法测定双唑泰泡腾片中甲硝唑、克霉唑和醋酸洗必泰的含量

HPLC Determination of Metronidazole , Clotrimazole and Chlorhexidine Acetate in Their Compound Effervescent Tablets

结果表明：第4周时，特比萘芬组治疗趾间型足癣临床有效率91.2%（克霉唑组92.8%，P＞0.05）；

Overall effective treatment rates at 4 weeks were 91.2 % for terbinafine group and 92.8 % for clotrimazole group ( P > 0.05 );

目的观察应用维生素AD滴剂联合克霉唑治疗婴儿尿布性皮炎的临床疗效。

Objective To study the clinical effects of vitamin AD combined with clotrimazole on infant diaper dermatitis .

结论应用维生素AD滴剂联合克霉唑治疗婴儿尿布性皮炎有良好效果，并无明显不良反应。

Conclusion Vitamin AD combined with clotrimazole is effective and has no side-effect for infant diaper dermatitis .

两组治疗耐受性均好，特比萘芬组的药物不良反应发生率2.1%（克霉唑组0.8%，P＞0.05）。

Tolerability was good in both treatment groups , with drug-related cutaneous adverse events in 2.1 % of terbinafine patients and 0.8 % of clotrimazole patients .

在9种抗真菌药药敏试验中，5-氟胞嘧啶、氟康唑、克霉唑、两性霉素B、制霉菌素有较高的敏感性。

Sensitivity results to nine antifungals showed that 5-flucytosine , fluconazole , clotrimazole , amphotericin B , and nystatin had higher drug sensitivity to these fungi .

体外药敏试验显示对伊曲康唑、两性霉素B、制霉菌素高度敏感，酮康唑、克霉唑低度敏感，氟康唑耐药。

The drug sensitive test in vitro indicated that itraconazole , amphotericin B and nystatin were highly sensitive , ketoconazole and clotrimazole were low sensitive , fluconazole was resistant .

RP-HPLC法测定克霉唑溶液中克霉唑的含量

Determination of Clotrimazole in Clotrimazole Solution by RP-HPLC

结果：检测出的念珠菌对特比萘芬耐药，对氟康唑、酮康唑、咪康唑、克霉唑中度敏感，对制霉菌素、伊曲康唑、两性霉素B、氟胞嘧啶高度敏感。

Result : Candida species are resistant to terbinafine , medium susceptible to fluconazole 、 ketoconazole 、 miconazole and clotrimazole , high susceptible to nystatin 、 itraconazole 、 amphotericin B and flucytosine .

结果：克霉唑分解反应的活化能E为131.0kj·mol-1，反应级数n为1029。

Was Used . RESULTS : The Energy and Progression of decompose reaction of clotrimazole are 131.0 kj · mol - 1 and 1.029 respectively .

益康唑和克霉唑对血小板聚集及TXB2和PGE2生成的影响

Effects of econazole and clotrimazole on platelet aggregation and TXB_2 and PGE_2 production in platelets

结论：克霉唑对人结肠癌细胞系CCL229有明显的凋亡诱导作用，并且能特异地诱导G1期细胞凋亡。

Conclusion : CLT can induce apoptosis in vitro in human colon cancer cell line CCL 229.The apoptosis inducing effect may be G1 phase specific .

克霉唑对Paneth细胞防御素分泌的抑制作用

Inhibition of clotrimazole on Paneth cell defensins

并对克霉唑乳酸配方阴道栓和制霉菌素治疗RVVC的疗效进行观察。

The efficacy of clotrimazole vaginal suppositories and nyspapinum in treating RVVC was observed .

用注射方法分别制备3种双分子层脂膜（BLM），并运用循环伏安法测量了修饰物克霉唑加入前后人工双分子层脂膜的电性质。

Using the injecting method , we prepared three bilayer lipid membranes ( BLM ) respectively , and by the cyclic voltammetry method we determined properties of BLM before and after adding clotrimazole into the membranes .

差热分析法测定克霉唑分解反应动力学参数

Determination of the kinetics parameters of decomposition reaction of clotrimazole by DTA

克霉唑大剂量一次给药治疗真菌性阴道炎

Single-high-dose treatment of Candida vaginitis with clotrimazole vaginal tablets

分光光度法测定复方克霉唑软膏中克霉唑的含量

Determination of Clotrimazole in Compound Clotrimazole Ointment by Spectrophotometry

目的：测定克霉唑分解反应动力学参数。

OBJECTIVE : To determinate the kinetics parameter of decompose reaction of clotrimazole .

克霉唑溶液的平均回收率为100.9%。

The average recovery of clotrimazole was 100 . 9 % in clotrimazole solution .

化合物3-苄基-6-氯硫色满酮的抗真茵活性与克霉唑相当。

The activity of3-benzyl-6-chlor-thiochromanone is equal to clotrimazole 's.

超过反抗霜通常包括药物，如克霉唑和咪康唑。

Over the counter antifungal creams usually include drugs such as clotrimazole and miconazole .

结论：大佛康治疗真菌性角膜溃疡疗效优于克霉唑。

Conclusions : Diflucan is more powerful than miconazole on the treatment of fungicidal keratohelcosis .

克霉唑的一锅合成工艺

One - pot synthesis of clotrimazole

乳杆菌活菌制剂辅助克霉唑阴道片治疗阴道假丝酵母菌病临床观察

Clinical observation of mycobacterium lacticola preparation in treatment of vaginal vini candidiasis using clotrimazole effervescent tablets

采用反相高效液相色谱法测定妇康载体栓中的甲硝唑、克霉唑和醋酸氯己定。

Methods : The contents of metronidazole , clotrimazole and chlorhexidine acetate were detected by RP-HPLC .

目的：介绍克霉唑甘油搽剂的制备、质量控制及其临床应用。

Objective : To introduce the preparation , quality control and clinical effect of clotrimazole glycerol solution .