东莨菪碱

采用HPLC和GC法分别测定了东莨菪碱和麝香酮的含量。规定了乌头碱的限量检查。

The content of scopolamine and muscone were determined separately by HPLC and GC .

兔扣带回亚区东莨菪碱干预对P（3a）波影响的实验研究

An experimental study of the effects of scopolamine on rabbit P_ ( 3a ) potential

结论腹腔注射咪达唑仑50mg/kg（连续3d）可短暂加重东莨菪碱致大鼠认知功能障碍。

Conclusion Midazolam can aggravate transiently the cognitive dysfunction induced by scopolamine in rats .

HPLC测定氢溴酸东莨菪碱的含量和有关物质

Determination of content and related substances of Scopolamine hydrobromide by HPLC

HPLC法测定氢溴酸东莨菪碱注射液的含量

HPLC determination of scopolamine hydrobromide injection

本文用FT－Raman光谱研究了东莨菪碱和神经鞘磷脂的相互作用。

The interaction of scopolamine with sphingomyelin was investigated by FT Raman spectroscopy .

东莨菪碱EVA控释膜的物理化学性质与释药速率关系的研究

Relationship between physicochemical properties of membranes and release rate of scopolamine from EVA rate-controlling membranes

目的研究东莨菪碱致记忆障碍大鼠模型中枢电压依赖性钾通道亚型mRNA表达的差异。

AIM To study mRNA expression difference of voltage dependent potassium channels in the brain of scopolamine induced memory impaired rats .

本文用离子对HPLC法测定了天仙子中莨菪碱和东莨菪碱的含量。

The contents of hyoscyamine and scopolamine in the seeds of Hyoscyamus niger were determined by applying reverse phase ion-pair HPLC .

侧脑室注射40μg的东莨菪碱后，海马神经元的自发活动无明显改变。

After intraventricular injection of scopolamine ( 40 μ g ) which inhibits the conditioning performance , the discharge rate of spontaneous unit activity showed no obvious changes ;

东莨菪碱对实验性ARDS动脉血气及血浆ET-1的影响

The influence of scopolamine on the change of artery blood gas and plasma ET-1 in experimental ARDS rabbits

针药结合治疗学习记忆障碍的机制&对东莨菪碱所致获得性学习记忆障碍大鼠海马NO和NOS的影响及其相关性

Influence of Combining Acupuncture and Medicine on NO and NOS in Rats ' Hippocampi with Acquired Learning-memory Disturbance and Their Correlation

FT-Raman光谱研究东莨菪碱和神经鞘磷脂的作用

FT Raman Spectroscopic Study of the Interaction of Scopolamine with Sphingomyelin

结果：小鼠给予东莨菪碱（1mg·kg-1，ip）后，其潜伏期显著减少，表明造成了明显的记忆损伤。

RESULTS : Animals displayed marked decrease in the step-through latency after administration ( scopolamine 1 mg · kg - 1 , ip ) .

东莨菪碱（i.p.）

Scopolamine ( 0.05 mg / kg , i.p. )

结果：东莨菪碱和阿托品的平均回收率分别为99.6%和100.4%；RSD为1.8%和1.5%。

Result : The mean recovery was ( 99.6 ± 1.8 ) % for scopolamine and ( 100.4 ± 1.5 ) % for atropine .

200mg/kg剂量的DHA能拮抗东莨菪碱所致的记忆障碍，提高记忆获得能力。

The results also showed that DHA , at 200 mg / kg , could antagonize dysmnesia caused by scopolamine and had hypermnesia effect .

结果提示：M胆碱能受体阻断剂东莨菪碱可以同时调制HPC癫痫网络成员电场和细胞的瞬时编码信息；

It suggested that the temporal coding information of the member fields and neurons could be modulated by the scopolamine simultaneously within hippocampal epileptic network .

结果：纳洛酮可易化杏仁核点燃，可乐定、东莨菪碱、MK-801和尼卡地平则可抑制杏仁核点燃发作（P0·05）。

Results : Naloxone facilitated , while clonidine , scopolamine , MK-801 and nicardipine inhibited amygdala kindling ( P0.05 ) .

东莨菪碱与绞股蓝皂甙XLⅢ对记忆调节系统Glu/GABA的作用比较

Comparison of Effects of Scopolamine and GynosaponinXL ⅲ on Levels of Glu / GABA in Memory Regulation System of Mice

方法：采用东莨菪碱、D-半乳糖和老年大鼠三种痴呆动物模型，使用Y型电迷宫和Morris水迷宫法，从整体动物水平研究药物对大鼠的学习记忆的影响；

Methods : MG-2 type Y-electronic maze and morris water maze were used to study the behaviors of senile model rats and dementia model rats induced by scopolamine and D-galactose .

结论由α受体、M1和M2受体介导的室旁核神经元能分别被东莨菪碱所阻断。

These results suggest that the changes of electric activity of PVN mediated by α and M1 and M2 receptors can be antagonized by scopolamine separately through blockade of those receptors .

GLS能够改善东莨菪碱所致小鼠的记忆获得障碍和乙醇所致记忆再现障碍。

GLS improve acquisition impairment of memory induced by scopolamine and reappearance impairment of memory induced by alcohol in mice . 3 .

结论：东莨菪碱干预疗法可以使HIE患儿脑组织及脑功能在前6个月得到充分改善，减少了HIE后遗症。

Conclusion : During treating infants with HIE , scopolamine can make the cerebral functions improved at the key age , alleviate cerebral ischemia injury obviously and reduce the rate of sequelae .

与39例未用东莨菪碱的患儿比较，在治疗HIE所致的反复窒息与惊厥方面取得良好的效果。

Compared with the results of the treatment of the other 39 cases in whom hyoscine was not employed , the hyoscine treatment was far better in handling repeated apnea and convulsion caused by HIE .

方法：采用小鼠水迷宫行为实验法，检测SSF对东莨菪碱、戊巴比妥钠引起小鼠学习、记忆障碍的作用。

Methods : The mice water maze performance was used to evaluate the effects of SSF on learning and memory deficits of mice induced by scopolamine and carbrital .

结论：TAK-147作为一个新的胆碱酯酶抑制剂，能明显改善东莨菪碱造成的大鼠空间学习记忆障碍。

Conclusion : A novel acetylcholinesterase inhibitor , TAK 147 ameliorates the scopolamine induced impaired spatial memory in rats .

HSH-971对东莨菪碱致记忆障碍大鼠学习记忆的影响及其机制探讨

Effect of HSH-971 on scopolamine induced impairment of learning and memory in rats and its related mechanisms

目的观察电针对麻醉状态下正常和东莨菪碱引起的学习记忆减退模型大鼠海马突触EPSP长时程增强（LTP）的作用。

OBJECTIVE To observe the effect of electrical acupuncture on long-term potentiation ( LTP ) of excitatory postsynaptic potential ( EPSP ) of normal rats and rats with hypomnesia induced by scopolamine .

8日龄组每日分别腹腔注射东莨菪碱（3mg/kg）、酚妥拉明（5mg/kg）和生理盐水，连续注射10d后，进行SAC实验。

Eight-day rats received daily intraperitoneal injection of scopolamine ( 3 mg / kg ), phentolamine ( 5 mg / kg ) and saline respectively for 10 days . The SAC test was performed after 10 days .