tregs

Immunotherapy based on Tregs infusion is therefore a potential treatment for many immune disorders .

而且基于CD4+CD25+调节性T细胞输注的相关免疫治疗可能成为许多免疫失调疾病有效的治疗方法。

Expression and Significance of CD4 + CD25 + Tregs in Leukemia

CD4~+CD25~+调节性T细胞在白血病中的表达及临床意义

But potential roles of Notch signaling in the development and functional maintenance of Tregs are still unclear .

但是Notch信号在nTregs的发育和功能维持中具体作用仍不清楚。

In a word , our study investigates the relationship and the interaction between IDO and Tregs cells .

总之，本研究探讨了IDO和Tregs细胞在体内外的相互联系与作用。

Regulatory T cells ( Tregs ) play an essential role in modulating the immune system and maintaining peripheral tolerance .

调节性T细胞（Tregs）在免疫调节和维持外周免疫耐受方面起重要作用。

Background and Objectives : It is currently known that regulatory T cells ( Tregs ) play an important role in transplantation and tumor immunity .

背景：目前已知调节性T细胞（Tregs）在移植和肿瘤免疫中都发挥了重要的作用。

Recent studies of immune tolerance have focused on the role of a subset of T cells , called regulatory T cells ( Tregs ) .

关于免疫耐受的近期研究集中在一种称为调节性T细胞（Treg）的T细胞亚群的作用。

The results indicated that the paw swelling is negatively related to the percentage of CD4 + CD25 + Tregs in CIA rats , and the coefficient correlation is -0.786 .

结果表明：CIA大鼠足爪肿胀与CD4+CD25+调节性T细胞（CD4+CD25+Tregs）的比例呈负相关，相关系数为-0.786。

AIM To investigate the effects of total base of Sophora alopecuroides on expression of CD4 + CD25 + , CD8 + CD28 - Tregs in rats with experimental colitis .

目的：观察苦豆子总碱对实验性结肠炎大鼠的外周血和结肠组织中调节性T细胞（Tregs）CD4+CD25+、CD8+CD28-表达的影响。

Tregs mediate the incidence and outcome of CM in P.bANKA infected mice by modifying the pro-inflammatory response to modulate the balance of pro-and anti-inflammatory responses .

Tregs通过修饰前炎症应答从而调控前炎症应答与抗炎症应答之间的平衡以介导CM的发生和感染结局。

Establishing an appropriate balance between pro-and anti-inflammatory immune responses is essential to control pathogenesis of severe malaria , and Tregs is an important regulator if this balance can be maintained . 2 .

结论1、前炎症应答和抗炎症应答之间平衡的设立对控制重型疟疾发生至关重要，Tregs是维持此平衡的重要调节因子。

As a necessary subset of natural occurring regulatory T cells , CD4 + CD25 + regulatory T cells ( Tregs ) play an important role in modulating the immune system and maintaining peripheral tolerance .

CD4+CD25+调节性T细胞（regulatoryTcells，Tregs）是天然产生的调节性T细胞的重要亚群之一，在调控免疫系统和维持外周耐受方面起着重要作用。

CONCLUSION Total base of Sophora alopecuroides can regulate down the expression of CD4 + CD25 + 、 CD8 + CD28 - Tregs in order to improve the symptom with colitis .

结论：苦豆子总碱通过下调CD4+CD25+、CD8+CD28-Tregs的表达来减轻或改善实验性结肠炎大鼠的症状，为临床应用做一探讨。

Effects of the total base of Sophora alopecuroides on the expressions of CD4 ~ + CD25 ~ + and CD8 + CD28 ~ - Tregs in rats with experimental colitis

苦豆子总碱对大鼠实验性结肠炎CD4~+CD25~+，CD8~+CD28~-表达的影响

Objective To evaluate the proportion of CD4 ~ + CD25 ~ + - Tregs in the peripheral blood of the patients with nervous autoimmune diseases in order to investigate its effect on nervous autoimmune diseases .

目的通过分析神经免疫性疾病患者外周血中CD4~+CD25~+-Tregs的变化，探讨其在神经免疫性疾病发病中的意义。

The expression of CD4 + CD25 + Tregs on colon of colitis rats by midst and high dose of total base of Sophora alopecuroides was lower than model group ( P < 0.05 ) .

苦豆子总碱中、高剂量组对结肠部CD4+CD25+Tregs的调节与模型组相比有统计学意义（P<0.05）；

Because the number of Tregs that can be obtained from donor peripheral blood is limited , freshly isolated Tregs need to be expanded ex vivo to generate a sufficient number of cells for therapeutic applications .

由于从供者外周血采集分离到的Tregs的数量有限，新鲜分离的Tregs需要在体外进行扩增以获得临床应用所需的Tregs细胞数。

The expression of CD4 + CD25 + Tregs in autoimmune disease has been focused on , but the expression and mechanism of CD4 + CD25 + Tregs in RA is still not well-known and need further studying .

CD4+CD25+Tregs在自身免疫性疾病中的表达已成为目前研究的热点，但有关CD4+CD25+Tregs在RA中的表达与作用机制尚不明确，值得进一步深入研究。

Most critically , they then demonstrated that donor-derived Tregs were induced by the transfer of ECP-treated splenocytes , and that in vivo purging of Tregs eliminated the benefits of ECP .

最关键的，他们随后证明了在移植入ECP处理的脾细胞后诱导了捐者来源的Tregs，在体内清除Tregs会消除ECP的益处。

In peripheral blood of patients with gastric cancer , the percentage of Tregs in pre-operation was significantly higher than that of the control ( P0.01 ), the percentage of Treg in post-operation had no significant difference with the control ( P0.05 ) .

结果：1.胃癌患者术前外周血中Treg比例显著高于对照组，并具有统计学意义（P0.01）。手术后外周血Treg比例与对照组的比较，两者无统计学意义（P0.05）。

Compared with control group , the proportion of CD4 + CD25 + Tregs in colon was significantly increased in colon during the first week after week after establishing model ( t ≥ 2.2 , P < 0.05 ), and decreased to the normal range at the third week .

在第一周，CD4+CD25+Tregs在结肠部位较对照组增加（t≥2.2，P<0.05），于第三周回落至对照组水平。

Objective : To investigate the relationship between CD4 + CD25 + regulatory T cells ( CD4 + CD25 + Tregs ) and acute / chronic graft versus host disease ( a / cGVHD ) after allogeneic peripheral blood stem cell transplantation ( Allo-PBSCT ) .

目的：研究异基因外周血干细胞移植（Allo-PBSCT）后CD4+CD25+调节性T细胞（CD4+CD25+Tregs）与急、慢性移植物抗宿主病（a/cGVHD）的关系。

The abnormality of CD4 + CD25 + Tregs in quantity and function related to the development of autoimmune disease . More and more evidence indicate that CD4 + CD25 + Tregs are abnormal in RA patients and its disability is related to the occurrence and development of RA .

越来越多的证据表明，RA患者体内CD4+CD25+Tregs存在异常，CD4+CD25+Tregs的数量和/或功能不足可能与RA的发生、发展有关。