转录延伸

RNA聚合酶Ⅱ转录延伸因子

RNA Polymerase ⅱ Transcription Elongation Factors

此外，转录延伸速率也与可变剪接相关。

Moreover , the rate of transcription elongation has been linked to alternative splicing .

在RNA聚合酶Ⅱ介导的转录延伸过程中，其和模板DNA及转录产物RNA紧密结合，形成一个非常稳定的延伸三维复合物（elongationcomplex，EC）。

The sliding clamp model of transcription processivity suggests the formation of a highly stable elongation complex ( EC ), in which RNA polymerase is tightly bound to the nascent transcript and template forming the characteristic transcription " bubble " .

RPS5具有转录延伸因子3（EF-3）的功能；

RPS5 has the duplication to extend the factor 3 ( EF-3 ) function .

Elongator是真核生物中一个保守的组蛋白乙酰转移酶复合物，由六个亚基组成，被认为具有辅助转录延伸的功能。

The Elongator is a conserved protein complex , which consists of six subunits with the histone acetyl transferase activities in eukaryotes . The biological function of this protein complex was thought to facilitate transcriptional elongation .

已经证明该复合物在以染色质为模板的转录延伸中具有非常重要的作用。

This complex has been shown to be important for transcription elongation through a chromatin template .

通过乙酰化特异染色质区组蛋白尾部的赖氨酸残基，Elp3参与特异染色质区结构的改变，为染色质结构调控蛋白提供识别信号，在转录延伸中发挥重要的作用。

As a transcription elongation factor , it plays important roles in recruiting chromatin remodeling proteins , and in modulating chromatin structure by acetylating the highly conserved lysine residues in N-terminal tails of histones .

下调蛋白与蛋白的转录和延伸、RNA的加工和合成、糖降解、氨基酸的转运和代谢、泛素蛋白酶体途径、信号转到、基因调控相关。

The down-regulated protein associated with protein translation and elongation , RNA processing and biosynthesis , carbohydrate degradation , amino acid transport and metabolism , the ubiquitin-proteasome pathway , signal transduction , and gene regulation .

RNA聚合酶对转录调节作出抉择依赖于对转录延伸复合物内在的或外来的信息输入，其功能在很大程度上都像是一个信息加工者。

The decision of RNA polymerase for transcriptional regulation depends on the intrinsic or extrinsic imputs of information to transcription elongation complex . Thus , the function of RNA polymerase looks like an information processor to a great extent .

在体外去除HeLa细胞抽提物中的Elongator复合物可降低其转录染色质模板的速率，也为人Elongator复合物参与转录延伸提供了生化证据。

In vitro , the removal of Elongator complex from the HeLa nuclear extracts can decrease the rate of transcription of chromatin templates , which also provides biochemical evidence that human Elongator complex takes part in the transcription elongation .

RNA聚合酶II是在真核生物中负责转录和加工mRNA的聚合酶，由12个亚基组成，最大的亚基Rpb1是其主要的功能亚基，决定了转录的起始和延伸。

RNA polymerase II is responsible for the synthesis and process of mRNA in eukaryotic cells and is composed of 12 subunits . The largest subunit of RNA polymerase II ( Rpb1 ) plays the most important role , which determinates the initiation and elongation of transcription .