蛋白酶体

泛素依赖的蛋白酶体水解通路对p53转录活性的作用

Ubiquitin - dependent Proteasome Proteolysis is Involved in Both p53 Transactivation and Degradation

蛋白酶体抑制剂在TRAIL诱导恶性淋巴瘤细胞凋亡中的协同作用

Synergistic Effects of Proteasome Inhibitor on TRAIL-induced Apoptosis in Malignant Lymphoma Cells

泛素-蛋白酶体系统在核因子κB途径中的作用

Role of Ubiquitin-proteasome System in the NF - κ B Signaling Pathway

CHIP可以作为α-突触核蛋白蛋白酶体降解途径和溶酶体降解途径的分子开关。

CHIP acts as a molecular switch between proteasomal and lysosomal degradation pathways .

高温胁迫促进了泛素蛋白酶体系统（UPS）基因表达。

Ubiquitin-proteasome system ( UPS ) was enhanced under heat stress .

2条参与蛋白酶体降解途径的基因显著上调，多条与细胞信号传导、RNA加工及蛋白质合成相关的基因下调。

Among the 9 up regulated genes , 2 genes were involved in proteasome degradation pathway .

目的：探讨泛肽蛋白酶体对TRAIL诱导细胞凋亡作用的影响。

Objective To determine the influence of ubiquitin-proteasome in regulating the TRAIL-mediated apoptosis .

细胞内ATP浓度决定蛋白酶体抑制诱导细胞死亡的敏感性

Intracellular ATP Concentration Determines the Sensitivity of Cell Death Induced by Proteasome Inhibition

有研究证明，蛋白酶体抑制可以通过降低NF-κB的活性而减轻压力负荷导致的心肌重构，从一定程度上逆转心肌肥大。

Proteasome inhibitor could reduce the myocardium remodeling caused by pressure overload by inhibiting the activity of NF - κ B , resulting in reverse of cardiomyocyte hypertrophy .

而细胞内的DCN在外界因素作用下，可能通过内质网应激（ERstress），经泛素-蛋白酶体系统调节降解。

However , intracellular DCN under external factors , can be degraded by Ubiquitin proteasome pathway through ER stress .

结论噬菌体颗粒抗原交叉呈递是以TAP依赖的方式进行，并对多种蛋白酶体抑制剂敏感。

Conclusion Cross presentation of phage particles is TAP dependent and sensitive to proteasome inhibitors and NH_ ( 4 ) Cl.

进而，采用流式细胞技术研究了不同蛋白酶体抑制剂以及TAP对噬菌体颗粒抗原交叉呈递的影响。

Furthermore , the effect of proteasome inhibitors and TAP on particle antigens cross presentation was investigated by FACS analysis .

若使用蛋白酶体抑制剂抑制酶的活性，可产生剂量依赖性选择性多巴胺（Dopamine，DA）神经元死亡。

The application of protease inhibitors which inhibit proteasome activity can produce dose-dependent selective death of DA neurons .

泛素化过程除了参与蛋白酶体降解之外，还参与调节许多生物学过程，包括细胞内转运，DNA修复，信号传导和蛋白质蛋白质相互作用。

Ubiquitination is a key mechanism in regulating many biological processes not only proteasome degradation , but also endocytic trafficking , DNA repair , signal transduction and protein-protein interaction .

一些有前景的药物如沙利度胺、蛋白酶体抑制剂、砷剂等的应用使MM的治疗得到了极大的突破。

Applications of several perspective drugs such as Thalidomide , proteasomes inhibitor , arsenical and other agents bring galactic breakthrough to the treatments of MM .

现代的诱导治疗方案、造血干细胞移植、沙利度胺及新型蛋白酶体抑制剂的应用，MM的疗效得到不断提高。

With the development of modern induction therapy , hematopoietic stem cell transplantation and the application of thalidomide , the efficacy of MM are rising .

大量研究发现，恶病质状态下骨骼肌蛋白降解通过ATP泛素蛋白酶体途径。

In recent years , accumulating evidences suggest that the ATP ubiquitin proteasome pathway may be crucial in muscle cachexia .

Eda等自由基清除剂可通过清除自由基而保护蛋白酶体的活性或功能，因此可能对具有治疗作用。

Free radical scavenger such as Edaravone protected proteasome activity and function and may be have therapeutic action .

泛素-蛋白酶体途径是生物体内进行蛋白质选择性降解的重要途径之一，广泛参与细胞周期调控、DNA修复、细胞信号转导、细胞凋亡等多种生理过程。

Aim Ubiquitin-proteasome pathway is an important pathway of protein degradation in cells , it is involved in many physiological processes including cell cycle regulation , DNA repair and cell apoptosis .

蛋白酶体抑制剂联合伊马替尼对K562细胞livin基因表达的影响

Effect of proteasome inhibitor combined with imatinib on expression of livin mRNA in K562 cells

家兔心肌自溶蛋白质降解与死亡时间的关系泛素依赖的蛋白酶体水解通路对p53转录活性的作用

THE SIGNIFICANCE OF DETERMINING PROTEOLYSIS OF AUTOLYZING MYOCARDIUM FOR THE TIMING OF DEATH Ubiquitin-dependent Proteasome Proteolysis is Involved in Both p53 Transactivation and Degradation

ω-3脂肪酸对脓毒症大鼠骨骼肌20S蛋白酶体活性的影响

The effect of ω - 3 fatty acid on skeletal muscle in septic mice

蛋白酶体抑制剂MG-132逆转人结肠癌细胞获得性TRAIL耐药

Proteasome inhibitor MG-132 reverses acquired resistance to TRAIL in human colon cancer cells

泛素-蛋白酶体通路对TRAIL诱导结肠癌细胞株SW1116凋亡作用的影响

The influence of ubiquitin-proteasome in regulating the TRAIL-mediated apoptosis of colon carcinoma cells

蛋白酶体抑制剂MG-132诱导K562细胞凋亡的实验研究

Induction of apoptosis by proteasome inhibitor MG-132 in human erythroleukemia cell line K562

真核细胞的蛋白降解是一个动态且复杂的过程，泛素蛋白酶体系统（ubiquitin-ProteasomeSystem，UPS）在这个过程中扮演着重要的角色。

Eukaryotic protein degradation by the proteasome and the lysosome is a dynamic and complex process in which ubiquitin-proteasome system ( UPS ) has a key regulatory role .

泛素蛋白酶体通路在ATRA诱导白血病细胞分化与周期调控中的作用研究

The Ubiquitin-proteasome Pathway Involved in ATRA-induced Leukemia Cells G1 / G0 Phase Arrest and Transition into Differentiation

蛋白酶体在脑黑质变性和Lewy小体形成中的作用

The roles of proteasome on nigral degeneration and Lewy body formation

目的分离纯化正常大鼠脾脏20S蛋白酶体，并观察其形态特征。

Objective To isolate and purify 20S proteasome from normal rat spleen and observe its morphologic features .

研究表明，脑缺血后应用蛋白酶体抑制剂可有效改善神经细胞变性、缩小脑梗死灶体积、减少白细胞浸润和降低NF-κB活性，发挥神经保护作用。

Studies have suggested that proteasome inhibitors may effectively improve neuronal degeneration , reduce size of cerebral infarction , decrease neutrophil infiltration and NF - κ B immunoreactivity after cerebral ischemia , and thus exerting neuroprotective effect .