肿瘤发生

Wnt抑制因子-1与Wnt通路和肿瘤发生

Wnt Inhibitory Factor-1 , the Wnt Signal Transduction and Oncogenesis

充实的证据表明炎症能够促进肿瘤发生，偶尔也会参与癌症排斥。

Substantial evidence shows that inflammation promotes oncogenesis and , occasionally , participates in cancer rejection .

DNA含量及细胞周期调控基因的表达在甲状腺肿瘤发生中的作用

DNA content and expression of cell cycle gene in thyroid carcinoma

TAM＋RA组无乳腺肿瘤发生（P＜0.01）。

In group D , no breast carcinoma was found ( P < 0 . 01 ) .

肿瘤发生的遗传机制；体细胞突变的发生机制；DNA修复，基因组学与分子医学。

Cancer genetics , somatic mutagenesis , DNA repair , genomics and molecular medicine .

目的探讨hSpry2基因在136例肿瘤发生中的作用。

Objective To study h Spry 2 gene 's role in the tumorigenesis .

另外，DNA的损伤也是恶性肿瘤发生的重要原因之一。

In addition , DNA damage is also one of the important reasons for malignant tumor .

Cyclinb1与肿瘤发生发展

Effects of cyclin B_1 on the genesis and development of neoplasm

其中对组织屏障&细胞外基质（extracellularmatrixECM）的降解是肿瘤发生转移的重要步骤。

Degradation of extracellular matrix ( ECM ) is a key step for metastasis .

Notch与Ras/MAPK信号通路在胚胎发育及肿瘤发生中的串话

Crosstalk Between Notch and Ras / MAPK Pathways in Embryonic Development and Tumorigenesis

其异常表达与许多疾病的发生发展有关，与肿瘤发生发展尤为密切，一般认为bcl-2通过抑制诱导凋亡的信号而在肿瘤发生中起作用。

Many people think bcl-2 have the role in tumor by inhibition signal which induce apoptosis .

结论胚胎恶性肿瘤发生机制可能与成人肿瘤不同，微卫星DNA变化在Wilms肿瘤不常见。

Conclusions Microsatellite instability , unlike that of adult tumors , is rare in Wilms ' tumor .

第二，Rb蛋白可以通过特异性结合肿瘤发生相关的蛋白抑制肿瘤细胞活性。

Secondly , Rb protein can inhibit tumor cell activity by specifically combining with tumor-related proteins .

分析myc小鼠的转基因复本和肿瘤发生

Analysis of transgenic copies and tumor development in mice bearing myc genes

但是，长期以来HRT被认为可增加激素依赖性肿瘤发生与复发的危险性。

Many researchers thought HRT could increase the prevalence and recurrence of hormone dependent tumor .

结论cyClinD1的表达是肿瘤发生中的早期事件，参与癌前病变的发生并影响癌细胞分化程度。

Conclusion Overexpression of cyclin D1 plays an important role in the differentiation and development of cancer .

目的研究胃恶性肿瘤发生与ABO血型抗原分布关系。

Objective To study the relativity between etiology of stomach carcinoma and ABO blood type antigen distribution .

这些都说明了REGγ在肿瘤发生发展中的作用。

All these findings demonstrated the role of REG in tumorigenesis .

目的：研究髓母细胞瘤中IL-6基因表达与肿瘤发生和发展关系。

Objective : To evaluate the significance of IL-6 gene expression in children medulloblastomas and its relationship with the evolution and progression in medulloblastoma .

目前对SV40在肿瘤发生过程中所扮演的具体角色和确切机制还不十分清楚。

But the mechanism of the tumorigenesis of SV40 Tag is not clear .

G1→S期之间的调控点是细胞内外信号经传递、整合汇集到细胞核，对细胞的增殖进行调控的关键点，该点调控异常与肿瘤发生、发展关系密切。

The checkpoint between G1 and S phase is a key point involved in the regulation of cell proliferation , through which the intracellular and extracellular signal can be transmitted and integrated to nucles .

在肿瘤发生中，M-CSF及其受体的异常表达呈多水平的紊乱。

Dysfunction of M-CSF and its receptor during malignancy occurs in multiple levels .

自1990年发现Id分子以来，有关该分子在细胞发育成熟、增殖、分化、死亡和肿瘤发生等方面的作用已进行了广泛而深入的研究。

Since the identification of Id proteins in 1990 , the roles of Id in cell proliferation , differentiation , development , maturation , apoptosis and tumorigenesis have been widely investigated .

目的探讨神经胶质瘤组织中Ki-67抗原表达及其与肿瘤发生和恶性程度的关系。

Objective To explore the Ki-67 expression in human gliomas and its implication to tumorigenesis and the degree of gliomas ' malignancy .

流行病学调查发现：作为肿瘤发生的癌基因，HER-2在25%～30%的乳腺癌中过表达。

HER-2 was proved to be tumorigenic oncogene and over-expressed in 25 % ~ 30 % of the breast cancer .

有关VEGF在人脑肿瘤发生、演进中的作用以及抗肿瘤血管治疗的研究成为热点。

It has been a " hot spot " about VEGF in the role of the growth and development of human brain tumor and in the therapy study about anti-tumor angiogenesis .

另外星形细胞瘤（10／14，71.4%）和胶质母细胞瘤（9／9100%）之间并无统计学差别（P＝0.124），说明此路径异常与肿瘤发生有关而与分型无关。

However there was no statistical significance between astrocytomas ( 10 / 14 , 71.4 % ) and glioblastomas ( 9 / 9 , 100 % ) indicating that the pathway abnormalities was only associated with tumorigenesis but not with tumor types .

Wistar大鼠乳腺自发肿瘤发生率为2.0%，其中良性肿瘤为1.5%，恶性肿瘤为0.5%。

The incidence of Wistar rats was 2.0 % , in which the incidence of benign tumors was 1.5 % and that of malignant tumors was 0.5 % .

研究表明，Syk有抑制肿瘤发生和转移的功能，但Syk抑癌的分子机制仍大部分未明。

Syk could suppress tumorigenesis and metastasis , but the molecular mechanism remains unknown .

目的检测荷瘤鼠体内S-100蛋白及ICAM-1（细胞间粘附分子-I）的表达，探讨其与肿瘤发生、转移的关系。

Objective To study the relationship of the development and metastasis of B16 melanoma with expressions of S-100 protein and intercellular adhesion molecule-1 ( ICAM-I ) .