肿瘤特异性抗原

目的：研究肿瘤特异性抗原GAGE基因mRNA在BEL-7404肝癌细胞株中的表达情况，评价其作为分子肿瘤标记以及肿瘤免疫治疗特异性靶位的可能性。

Objective : To investigate the mRNA expression of cancer antigen GAGE gene in hepatocellular carcinoma ( HCC ) cell line .

近十年来已经成功分离出多种鼠或人的肿瘤特异性抗原，如小鼠门基因和人的MAGE、BAGE、GAGE家族等。

Many tumor specific antigens such as mouse PI A , human MAGE , BAGE and GAGE families had been isolated during recent decade .

近几年研究发现被肿瘤特异性抗原调节T细胞（Treg）激活的反调节效应T细胞在肿瘤治疗的作用上有重要的抑制作用。

The past few years has been found that regulate the tumor-specific antigen T cells ( Treg ) to activate the anti-regulatory effects of T cells in the tumor treatment has an important role on the inhibitory effect .

同时研究5&杂氮脱氧胞嘧啶（DAC）对子宫内膜癌细胞株KLE增殖和肿瘤特异性抗原MAGE、BAGE、GAGE表达的影响。

The other aim of this study was to investigate the effect of 5-aza-2 ' - deoxycytidine ( DAC ) in proliferation of endometrial carcinoma cell line and expression of tumor specific antigen MAGE , BAGE , GAGE .

以含有肿瘤特异性抗原表位的杂合型噬菌体（TSPA-M-A1）作为抗原，免疫C57BL/6J小鼠，观察免疫4周后小鼠的细胞免疫变化。

The C57BL / 6J mice were immunized with the purified hybrid phage , which displayed the tumor-specific antigen epitope MAGE-A1_ ( 161-169 ) ( TSPA-M-A1 ) .

肿瘤特异性抗原长循环纳米脂质体的制备及其抗肿瘤免疫效应

Preparation and antitumor immunity of long circulating Nano-Liposome encapsulated tumor specific antigen

展示肿瘤特异性抗原表位的噬菌体在小鼠体内引起的细胞免疫变化

Filamentous bacteriophage displayed tumor-specific antigen epitope ( MAGE-A1 ) induced cellular immune in mice

5-杂氮脱氧胞嘧啶对卵巢癌细胞株增殖和肿瘤特异性抗原表达的影响

Effect of 5-aza-2 ′ - deoxycytidine in Proliferation of Ovarian Cancer Cell Lines on Expression of Tumor Specific Antigen

但因缺乏肿瘤特异性抗原及高效的抗原递呈等，疫苗的效果远不能令人满意。

However , the potency of vaccines is poor owing to the lack of specific antigens and inefficient antigen presentation .

在真正意义上的肿瘤特异性抗原被发现以前，肿瘤细胞本身仍然是肿瘤抗原的最好来源。

Until the tumor specific antigen are identified , the tumor cell itself will continue to be the best source of immunizing antigen .

该技术在研究蛋白质之间的相互作用、寻找肿瘤特异性抗原和治疗性靶肽以及在新型诊断试剂和疫苗研制中都有重要用途。

The technique is widely used in exploring protein-protein interactions , finding specific antigens of tumor , cancer targeting therapeutic peptides , new diagnostic agents , and vaccine development .

由于许多肿瘤特异性抗原或相关抗原被发现以及抗体具有独特而优越的性能，抗体介导的肿瘤靶向治疗一直受到广泛关注。

Ascribed to the discoveries of many tumor specific / associated antigens ( TSAs / TAAs ) and the unique / excellent properties of antibody , the antibody-mediated targeting therapy of tumor persistently attracts worldwide attentions .

白血病细胞来源的DC保留了其原始肿瘤细胞的特异性肿瘤抗原。

These DCs reserved the specific tumor antigens .

肿瘤靶向治疗的关键在于发现肿瘤特异性抗原。

The identification of tumor-specific antigens is crucial for Ab-based tumor-targeting immunotherapy .

肿瘤疫苗主要是通过肿瘤相关抗原，尤其是肿瘤特异性抗原，激活免疫系统产生针对肿瘤的特异性免疫反应来达到治疗目的。

Cancer vaccines can generate specific immune response to get goals of treatment mainly through activate the tumor-resistant antigen ( TRA ), especially anti-tumor specific antigen .

肿瘤疫苗是目前肿瘤生物治疗的重要方法，它利用肿瘤特异性抗原进行主动免疫来激活和增强机体对肿瘤的免疫应答水平。

Tumor vaccine is an important approach for tumor biological therapy . By taking advantage of the initiative immunity to the specific antigen of tumor , it can activate and reinforce immune response to the tumor .

[摘要]目的肿瘤-睾丸抗原（Cancer-Testisantigens，CTA）是一大类肿瘤特异性抗原，具有在多种肿瘤中表达而在正常组织中只表达于睾丸的特点。

Objective Cancer-testis antigens ( CTA ) are a family of many kinds of tumor-specific antigens , and they express merely in testis and many kinds of tumors .

设计肿瘤预防性疫苗的一个难点是分离鉴定安全且具有免疫原性的并且具有有效靶向的肿瘤抗原，包括肿瘤特异性的抗原和正常组织中不表达而肿瘤组织中高表达的蛋白。

A major challenge for designing prophylactic cancer vaccines is to define immunogenic and safe cancer antigens that can serve as targets for effective vaccines , including tumor-specific antigens and proteins over-expressed on the tumor but not on normal tissues .