次乌头碱

建立了准确、灵敏的HPLC法测定三种双酯型生物碱〔乌头碱（aconitine）、次乌头碱（hypaconitine）和新乌头碱（mesaconitine）〕的含量。

HPLC method , sensitive and accurate , for the determination of three kinds of diester-diterpene type Aconitum alkaloids ( aconitine , hypaconitine and mesaconitine ) and HPLC method for the fingerprint were established .

结果表明：球形木质素树脂对次乌头碱和苦参碱均具有良好的吸附效果。

The results show that : spherical lignin resin absorbent has a good adsorption efficiency for Hypaconitine and Matrine .

在最佳分离条件下对中草药中乌头碱及次乌头碱含量进行了测定。

The content of the aconitine and hypaconitine in Aconitum medicinal herbs were determined under the optimum separation conditions .

肾气丸阴中求阳配伍对方中乌头碱和次乌头碱含量的影响

Influence of Compatibility of Shenqi-Pill " Reinforcing Yang from Yin " on the Content of Aconitine and Hypaconitine in the Decoction

目的建立血液中乌头碱、次乌头碱、新乌头碱的LC/MS/MS分析方法。

Objective To establish a method used for determination of Aconitine and Hypaconitine and Mesaconitine in blood by LC / MS / MS.

方法中所用试剂成本低、毒性小，适用于乌头碱、中乌头碱、次乌头碱的提取分离以及对照品的制备。

This method was at low cost , harmless and suitable for extracting , separating and preparing mesaconitine , aconitine and hypaconitine .

目的考察用乌头碱水解物、新乌头碱水解物、次乌头碱水解物的含量作为附片水煎剂及附片质量控制指标的可行性。

Objective To examine the feasibility of regarding the hydrolyzate from aconitine , new aconitine , and hypaconitine to be the decoction of radix aconite and the quality control index .

结论LC/MS/MS法灵敏可靠，样品处理快速简便，适用于血液中乌头碱、次乌头碱、新乌头碱的检测。

Conclusion The method of LC / MS / MS is sensitive and reliable , and the sample handling is quick and simple , which was suitable for determination of the Aconitine and Hypaconitine and Mesaconitine in blood sample .