多价疫苗

染色体整合系统在多价疫苗构建中的应用研究

A Chromosomal Integration System for Development of Polyvalent Vaccine Strains

以弱毒疫苗为载体可研制鱼类多价疫苗。

Attenuated vaccine is also be used as a vaccine carrier for thedevelopment of the polyvalent vaccine .

本文主要对血吸虫蛋白疫苗、DNA疫苗和多价疫苗候选抗原的研究进展作综述。

This paper reviews the progress on the candidate vaccine antigens including protein vaccine , DNA vaccine and multivalent vaccine against Schistosoma japonicum .

日本血吸虫基因工程BCG多价疫苗的研究

Study on BCG genetic engineering multivalent vaccine of Schistosoma japonicum

本研究为构建BCG多价疫苗奠定了基础。

The study provides the basis for BCG polyvaccine .

本研究为把BCG和其它分枝杆菌发展成为多价疫苗载体打下了基础。

The study should facilitate the developments of BCG and other mycobacteria into multivalent vaccine vectors .

A组RV血清型众多，疫苗研究实践表明，包含中和性抗原的多价疫苗的效果要好于单价疫苗。

Because of several rotavirus serotype , multivalent vaccine containing neutralizing antigen is superior to monovalent vaccine .

BCG/恶性疟MSP-2、CSP多价疫苗免疫小鼠应答类型研究

Studies on immune response type using BCG vaccination encoding Plasmodium falciparum MSP-2 and CSP in BALB / c mice model

结论细粒棘球绦虫Eg95抗原在BCG中成功表达，为BCG发展为多价疫苗载体奠定了基础。

Conclusion The E. granulosus 95 antigen gene in BCG is successfully expressed . The study could provide basis to develop the BCG multivalent vaccine vectors .

本研究证明了APP中三聚体自转运黏附素可以作为基因工程疫苗的候选靶位，并且为今后APP不同血清型新型多价疫苗研究、致病机理研究的建立提供必要的基础。

This study demonstrated in APP trimeric adhesin from a transfer can be used as genetic engineering vaccine candidate targets , and different serotypes of APP for the future of new multivalent vaccine research , the establishment of pathogenic mechanism to provide the necessary foundation .

结论：1NY-ESO-1蛋白在中高分化及肿块较大的TSCC组织中表达较高，可以进一步探索其作为TSCC免疫治疗多价疫苗的基础研究依据之一。

NY-ESO-1 protein has higher expression in the well differentiated and the bigger tumor tissues of TSCC . It can be further explored as one of the basic research in multivalent vaccine immunotherapy of TSCC .

目的研究恶性疟原虫FCC-1/HN株裂殖子表面蛋白-1（MSP-1）和表面蛋白-2（MSP-2）与BCG多价疫苗在小鼠体内诱导的免疫应答的特性及抗感染的保护性免疫机制。

Objective To explore immune response characteristics and protective immune mechanism induced by BCG vaccination of plasmodium falciparum merozoite surface protein-1 ( MSP-1 ) and merozoite surface protein-2 ( MSP-2 ) in BALB / c mice .

日本血吸虫23kD抗原表位及多价疫苗的初步研究

Epitope and ' cocktail ' vaccine of 23 kD antigen of Schistosoma japonicum

本研究旨在构建这种多期多价疫苗并探讨其免疫原性。

In this study , we aimed at constructing such a vaccine and investigated its immunogenicity in animals .

单一血清型免疫没有效果，推荐用当地优势血清型多价疫苗进行保护。

Single-serotype immunity had no effect , so we recommended to protect by the local dominant serotype multivalent vaccine .

因此在抗菌药物和多价疫苗双重选择压力下极可能获得传播优势，今后应对其密切监控。

Therefore , it is likely to obtain advantage of prevalence under dual selective pressure of antibiotics and vaccine , and should be closely monitored .

但是在全国范围内，应该积极使用并增加多价疫苗（能预防全部三种脊髓灰质炎病毒毒株）的使用。

But nationwide , the polyvalent vaccine ( which protects against all three strains of poliovirus ) should be aggressively used and coverage increased , he said .

空肠弯曲菌多价DNA疫苗的免疫保护效应

The immune protective efficacy of polyvalent DNA vaccines against Campylobacter jejuni invasion

目的构建日本血吸虫多价DNA疫苗。

Objective To construct a multivalent DNA vaccine .

目的为了便于多价DNA疫苗的制备和基因表达的研究。

Objective To study preparation of polyvalent DNA vaccine and the control of multiple gene expression .

Aβ（1-15）多价DNA疫苗的构建及其对体液免疫的效果

Construction of Multivalent Recombinant A β _ ( 1-15 ) DNA Vaccine and Its Effect on Humoral Immune

Aβ（42）重组多价DNA疫苗的构建及诱导Aβ抗体的产生

Construction of multivalent recombinant A β _ ( 42 ) DNA vaccine and induction of A β antibody

日本血吸虫Mr23000抗原与白细胞介素-12多价DNA疫苗诱导小鼠保护性免疫的研究

Protective immunity Induced by Multivalent DNA Vaccine of Schistosoma japonicum Mr23 × 103 Membrane Antigen and IL-12 in Mice

jejuni多价DNA疫苗。并探讨其在小鼠体内诱导特异性免疫应答的效应和在小鼠C。

Jejuni polyvalent DNA vaccine with effective mucosa immune response , explored the specific immune responses and immunoprotection in mice challenged with C.

以后还需在疫苗剂型上深入研究以增强表位肽的免疫原性而降低甚至避免副作用。本研究为B细胞表位肽疫苗和多价避孕疫苗的研究提供了实验基础。

How to enhance the immunogenicity of B cell epitope but alleviate or avoid side effects should be investigated further . But our study provided experimental ground - work for development of multivalent contraceptive vaccine .

目的探讨多价细菌疫苗&兰菌净预防原发性肾病综合征（PNS）患儿医院感染的疗效。

Objectives To Observe the effect of oral polyvalent bacterial vaccine Lantigen B on preventing nosocomial infection of children with primary nephritic syndrome ( PNS ) .

pCI-PIB-PIA接种小鼠后可见免疫小鼠肌细胞中PIB-PIA融合蛋白的表达，该结果可作为淋球菌多价DNA疫苗的研究基础。

With the availability of this fusion protein PIB-PIA , the future development of vaccine against Gonococcus will be facilitated .

目的探讨支气管哮喘合并反复呼吸道感染（RRI）经规律吸入糖皮质激素（ICS）控制不理想的儿童联用多价细菌疫苗（兰菌净）的临床疗效及安全性。

Objective To investigate the efficacy and safety of a polyvalent bacterial vaccine ( Lantigen B ) in asthma with recurrent respiratory infections ( RRI ) in children .

仔猪黄痢K88-K99-987p-F41多价菌毛疫苗的制备及小鼠免疫试验

Study on the Preparation of Multivalent Pili Oil-emulsion Vaccine for Yellow Scour of Piglets

犬联合多价核酸疫苗的实验免疫研究

Research on the combine nucleic acid vaccine and immunity of Canine