亚单位疫苗

重组黄热病毒E蛋白结构域Ⅲ作为亚单位疫苗的抗原性和免疫原性

Immunogenicity and Antigenicity of Recombinant Yellow Fever Virus Envelope Domain ⅲ as a Subunit Vaccine

目前疟疾疫苗主要历经减毒疫苗、亚单位疫苗和DNA疫苗三种形式。

At present , there have been three types of malaria vaccine : attenuated vaccine , subunit vaccine and DNA vaccine .

恶性疟原虫抗原表位的亚单位疫苗与DNA疫苗的联合免疫

Combined vaccination of DNA vaccine and subunit vaccine of malaria antigen epitope by intranasal route

灭活疫苗虽然安全有效，但免疫效力尤其细胞免疫作用受限制；基因工程亚单位疫苗和DNA疫苗等虽具有应用潜力，但也需提高其免疫，尤其是细胞免疫效果。

Deactivation vaccine although have effective security , it renders a restriction to immunity , especially cell immune restricted function .

利用分子生物技术也研究出了很多基因工程疫苗比如基因工程活载体疫苗、亚单位疫苗和DNA疫苗等。

There is a great deal of interest in the development of recombinant vector , DNA and protein subunit vaccines .

综合基因组学、生物信息学、DNA微阵列和蛋白质组学技术，可以对存在于病原体的不同成分给予充分详细的定性、定量测定，对研发亚单位疫苗有很大的帮助。

Comprehensive application of genomics , bioinformatics , DNA microarray and proteomics technology , can determine different components of the pathogens qualitatively and quantitatively .

目的探讨Aβ1-15亚单位疫苗接种对AD转基因模型鼠学习记忆能力的影响。

Objective To explore the effects of A β 1-15 peptide vaccine on learning and memory ability of transgenic model mice .

研究表明该蛋白酶在猪传染性胸膜肺炎的免疫保护过程中起一定的作用，该研究为APP亚单位疫苗的研制及应用提供了理论依据。

This research provided the foundation for development and application of the subunit vaccine on Actinobacillus pleuropneumoniae .

重组幽门螺杆菌尿素酶B亚单位疫苗（rHp）剂型及免疫途径的实验研究

Study on Preparations and Immunization Routes of Recombinant Urease B Subunit Vaccine of Hp

从疫苗的存在形式上看，可供选择的HIV候选疫苗包括下列几种：传统疫苗（灭活疫苗和减毒活疫苗）、合成肽和蛋白亚单位疫苗、DNA疫苗以及活载体疫苗。

Currently the HIV vaccine candidates include traditional vaccine ( killed or attenuated vaccine ), peptide , protein subunit , DNA vaccine and live vectorial vaccine .

弓形虫ADF基因亚单位疫苗与核酸疫苗的实验免疫研究

Immunoprotection of Subunit Vaccine and Nucleic Acid Vaccine of Toxoplasma Gondii ADF Gene

分别制备了6种表面多糖偶联抗原的油佐剂亚单位疫苗免疫小鼠，并以同样的方式制备3种未偶联表面多糖、PBS疫苗做对照。

And 3 unconjugated surface polysaccharides , PBS vaccine were prepared for control by the same method .

DNA疫苗是继减毒疫苗、灭活疫苗、亚单位疫苗和重组多肽疫苗之后的又一新型疫苗，比其它疫苗高效、安全且易于大量生产。

DNA vaccine is a new vaccine after live attenuated , whole killed , subunit and recombinant one , etc. It 's better than them at efficiency , safety and ease to produce .

CJ亚单位疫苗诱导淋巴细胞活化的实验研究

Study on activation of lymphocyte induced by CJ vaccine

鸡新城疫病毒HN基因亚单位疫苗诱导免疫保护的实验研究

Immunoprotection of Chickens from ND by Vaccination with Expressing HN Subunit Protein of NDV

鸡沙门氏菌外膜蛋白亚单位疫苗的研究&Ⅱ油乳剂型（OE）亚单位疫苗的研究

Studies on OMP Subunit Vaccine of Chicken Salmonella & II Studies on Oil Emulsion Subunit Vaccine

结果：有多种抗结核疫苗正在研究中，例如卡介苗、结核活疫苗、亚单位疫苗、DNA疫苗以及转基因植物疫苗等。

Results : There are many kinds of antituberculosis vaccines , such as the BCG vaccine , the live vaccine , the subunit vaccine ; the DNA vaccine and the transgenic plants vaccine , and so on .

结论噬菌体递呈肽能够模拟天然HSVgC抗原的部分免疫活性且具有一定的免疫原性，可用作HSV亚单位疫苗或表位疫苗的研究。

Conclusion Mimic peptide displayed by positive phages can be used as immunogen instead of the nature antigen for novel HSV vaccine development .

本实验为进一步研究M2生物学特性、建立M2特异性抗体的间接ELISA检测方法及研制M2亚单位疫苗奠定了基础。

So this assay layed foundation of studying biological characteristics , immunological theory of M2 protein and founding Indirect-ELISA approach to detect M2-specific anti-body of avian influenza virus .

该研究为猪传染性胸膜肺炎的免疫预防、亚单位疫苗的研制及基于ApxⅣ的PCR检测奠定了基础。

This study has established the foundation for control Porcine infectious pleuropneumonia in immune prevention , subunit vaccine and PCR diagnosis based on Apx ⅳ gene .

检测血清中中和抗体和IgG的水平，为HSV重组亚单位疫苗在小鼠模型中的评价奠定了基础。

The seral neutralizing antibodies and IgG were detected . This is the foundation for the evaluation of the HSV recombinant subunit vaccine in the mice mode . 1 .

目的分析器官移植受者人巨细胞病毒（HCMV）临床分离株糖蛋白H基因型，为进一步研究其致病性、免疫性以及研制HCMV亚单位疫苗提供依据。

Objective To investigate genotypes of glycoprotein H of human cytomegalovirus ( HCMV ) clinical strains from transplant recipient in order to study its pathogenicity , immunity and develop subvaccine .

流感疫苗经过五十多年的发展，主要有灭活全病毒疫苗、裂解疫苗、亚单位疫苗、DNA疫苗和减毒活疫苗。

Though influenza vaccines have been produced for over 50 years , vaccination is still the principal method of prophylaxis . Vaccines can be characterized as whole virus vaccines , split virus vaccines , surface antigen vaccines , DNA vaccines and live attenuated vaccines .

除了灭活疫苗、减毒疫苗、结合多糖疫苗和亚单位疫苗外，新近出现的DNA疫苗、转基因植物疫苗和ghost疫苗技术为疫苗的研制提供了新的思路。

It is important to explore an effective vaccine against it . With the development of vaccine strategy and technology , some new vaccines are being developed , such as DNA vaccine , transgenic plant vaccine , and ghost vaccine .

将Aβ42肽疫苗及Aβ36-42与七聚赖氨酸耦联制成的亚单位疫苗分别接种于SD大鼠，对照组用等体积PBS加铝佐剂。

A β 42 vaccine , subunit vaccine constructed with A β 36-42 and multiple antigens peptide were inoculated respectively into SD rats . PBS added aluminum adjuvant was inoculated into control group rats .

近年来，多项临床试验研究联合使用亚单位疫苗和抗病毒药物，或者直接优化现有疫苗后改进使用方法，均在治疗HBV感染方面取得了肯定的效果。

These years , some groups combined usage of subunit vaccines and antiviral drugs or they optimized vaccines directly and developed the methods of usage of vaccines in clinical trials , they all got the good results on anti-HBV therapy .

结论本研究成功构建了双价重组杆状病毒转移质粒为进一步构建双价L1蛋白表达系统进而建立双价基因工程亚单位疫苗打下基础。

Conclusion The bivalent recombinant baculovirus transfer plasmid will be applied to the constuction of bivalent L1 protein expression system , then contributed to the establishment the bivalent gene engineering subunit vaccine .

为了评价仔猪大肠杆菌病K88-K99-987P-F41四价亚单位疫苗的免疫效果，利用纯化粘附素为包被抗原，建立了检测产肠毒素性大肠杆菌粘附素抗体的间接ELISA。

An indirect ELISA for detecting antibodies to an K88-K99-987P-F41 subunit vaccine against piglet colibacillosis was established by using purified adhesions for coating antigens .

实验结果显示，ompU基因被认为是一种有效的疫苗候选基因，可用于研制亚单位疫苗和DNA疫苗预防由致病性哈维氏弧菌引起的鱼类养殖类疾病。

The ompU was identified to be a new effective vaccine candidate and could be used as subunit vaccine and DNA vaccine design for disease control caused by pathogenic V. harveyi .

试验结果表明：提取的IBRV多肽制作的亚单位疫苗具有良好的免疫原性，且抗体持续时间较长。

Results showed that IBRV subunit vaccine have better antigenicity and can last for a longer period of immunity .