双胍类

结果有超过66%的病人在应用双胍类药物。在有缺氧性疾病的患者中的应用超过50%；

Results According to the survey , the number of the paitents taking biguanide was 66 % , and over 50 % patients suffed from Anoxia disease and 27 % was still taking DBI .

双胍类口服抗高血糖药是治疗2型糖尿病的主要药物种类之一；

Biguanides are commonly used oral antihyperglycemic drugs in treating type II diabetes .

盐酸二甲双胍（metforminhydrochloride，简称MH）是双胍类降糖药，是目前临床应用最为广泛的降血糖药物之一。

Metformin Hydrochloride ( MH ) is a drug of the biguanides class , which is one of the most useful blood-glucose-lowering drug in clinical .

方法：随机选取90例IGT患者，分为双胍类药物治疗组、α-糖苷酶抑制剂治疗组和饮食、运动干预组。

Methods 90 IGT patients were selected in random , and divided into three groups : diet plus exercise group , Acarbose group and Metformin group .

方法对47例联合使用磺脲类、双胍类而血糖控制不好的患者每天早餐前加服4mg罗格列酮钠，进行为期12周的临床观察。

Methods A 12-week randomized , rosiglitazone sodium 4 mg / d added to 47 type 2 diabetes patients with poor glycemic control by sulfonylureas and metformin .

本研究以双胍类衍生物（简称H04）作为代谢调节剂，研究其对肉鸡生长、内分泌、免疫性能及肉品质的影响。

This thesis studied effects of guanidine derivative ( coded : H04 ) as metabolism regulator on growth , endocrine , immunity and meat quality in broiler chickens .

双胍类降糖药治疗糖尿病血乳酸水平的观察

Alteration of blood lactic acid level on biguanides therapy in diabetics

儿童糖尿病酮症酸中毒及双胍类药物治疗中乳酸酸中毒问题的研究

Lactic Acidosis in IDDM Children Treated with Biguanides

2型糖尿病患者双胍类药物的临床应用调查

Clinical Survey of Biguanides with Type 2 Diabetes

目前认为双胍类药物二甲双胍降低血糖但不不影响胰岛素分泌。

The biguanide metformin is believed to lower plasma glucose without affecting insulin secretion .

盐酸吡格列酮对磺脲类和双胍类药物联合治疗失效的2型糖尿病患者的疗效观察

Therapeutic effect of pioglitazone hydrochloride in type 2 diabetic patients poorly controlled with metformin and sulfonylureas

结果：糖尿病患者应用最多的药物为双胍类（40.4%），其次为磺脲类（38.9%）。

Results : Metformin was the most frequently used medicine ( 40.4 % ), followed by sulfonylurea ( 38.9 % ) .

结论一定要强调双胍类药物的禁忌症，提倡合理用药，避免滥用。

Conclusion It is important to emphasis the Contraindication of biguanides , and advocate rational use , and try to avoid abusing .

结论盐酸吡格列酮可改善磺脲类和双胍类药物联合治疗血糖仍未达标的2型糖尿病患者的血糖水平，提高胰岛素敏感性。

Conclusion Pioglitazone may improve blood glucose level that in type 2 diabetic patients uncontrolled with metformin in combination with sulfonylureas and increase insulin sensitivity .

二甲双胍是双胍类药物的代表药物，其降血糖作用的临床应用已有半个多世纪，在我国，二甲双胍是2型糖尿病的一线治疗药物。

It has been over half a century since its clinical application as anti-diabetic drug . Metformin is one of the important drugs of type 2 diabetes in China .

经胰岛素、补液、纠正酸中毒等综合治疗后，酸中毒消失，查肝肾功能等正常，加用双胍类药物（降糖灵29例，二甲双胍4例）。

21 patients ( 63.3 % ) had diabetes ketoacidosis ( DKA ) . When DKA and LA were abolished with insulin therapy and liver and kidney functions were normal , biguanides had been given to them ( phenformin for 29 cases ; metformin for 4 cases ) .