博来霉素

用流式细胞光度术研究表明，博来霉素A6对肝癌BEL-7402细胞有G2期阻断作用。

As shown by flow cytophotometry , bleomycin A_6 blocked the growth of liver cancer cells at G_2 phase .

方法：采用气管内注射博来霉素A5建立肺间质纤维化的大鼠模型。

Methods : Model rats were induced by injecting bleomycin A5 into trachea .

肿瘤病人博来霉素暴露后DNA修复能力的检测

Detection of the DNA Repair Capacity of Cancer Patients after Bleomycin Exposure

博来霉素通过插入DNA和RNA起作用。

Bleomycins act by intercalation of DNA and RNA .

在氧和其他金属离子特别是铜和铁离子存在时，博来霉素形成拟酶诱导DNA断裂。

In the presence of oxygen and metal ions , notably copper and iron , bleomycins form a pseudo-enzyme that induces DNA cleavage .

本文中，我们基于功能核酸成功地构建了两个电化学DNA传感器来分别检测小分子药物博来霉素和特定的靶标DNA序列。

In this paper , we fabricated two electrochemical DNA sensors based on functional nucleic acid to detect bleomycins and special DNA sequence successfully .

博来霉素A6和平阳霉素抗大肠癌实验研究

Study on Antitumor Activity of Bleomycin A6 and Pingyangmycin against Colorectal Cancer

CAI不仅能够对BLM诱导的小鼠肺纤维化有较好的疗效，而且能够缓解博来霉素的另一副作用&色素沉积。

CAI not only depressed bleomycin-induced pulmonary fibrosis in mice , but also relieved the other side-effect of bleomycin-pigmentation .

目的观察沐舒坦对博来霉素A5所致大鼠肺纤维化的干预作用及其可能机制，为肺纤维化的治疗探索一种新方法。

Objective To investigate the therapeutic effect of ambroxol in bleomycin-induced pulmonary fibrosis of rats .

本研究旨在通过不同时期运用外源性IL-10对博来霉素诱导的肺纤维化大鼠进行干预，探讨外源性IL-10对肺纤维化的作用机理。

This experiment is to investigate the effect of IL-10 on bleomycin-induced pulmonary fibrosis in rats by administrating exogenic IL-10 at its different stages .

3种化学诱变剂是丝裂霉素C（MMC，DNA交联剂）、博来霉素（BLM，似X线剂）、甲基甲烷磺酸酯（MMS，烷化剂）。

The three chemical mutagens were mitomycin C ( MMC , DNA crosslinker ), bleomycin ( BLM , radiometric agent ), methyl methanesulfonate ( MMS , alkylating agent ) .

博来霉素组肺损伤约在注射博来霉素后2周后出现，CT可见片状阴影及纤维索条状改变，病理学检查示肺大泡及局灶纤维化形成，以支气管及大血管周围为主。

The lung injury in bleomycin group happened after injection in the following 2 weeks , there were shadows and fibrosis cord changes through CT , the bullae formation and local fibrosis were observed around the main bronchi and vessels .

反义TIMP-1基因转染对博来霉素诱导的肺纤维化大鼠TIMP-1和MMP-2表达的影响

The Effect of Antisense-human TIMP-1 ( hTIMP-1 ) TIMP-1 Transfection on the Expression of and MMP-2 in the Lungs of Rats with Pulmonary Fibrosis Induced by Bleomycin

方法用博来霉素（BLMA6）6mg/kg气管内注入，诱生小鼠肺炎和肺纤维化；

Methods Bleomycin ( BLM A6 ) 6 mg / kg was used to induce pneumonia and pulmonary fibrosis in mice by single intratracheal instillation .

结论校正博来霉素法是一种较好的，能实际用于临床的常规测定NPBI的方法。

Conclusion The corrected bleomycin assay is a better method to estimate the concentration of plasma NPBI .

方法：选择20例健康献血者为实验对象，分为正常对照组、博来霉素（BLM）诱变组、中药合剂组和中药合剂抗诱变组。

Methods Twenty healthy blood donors were divided ( into ) four groups : control group , BLM induced group , traditional Chinese medicine mixture group and traditional Chinese medicine mixture anti-induced group .

除正常对照组外，其他大鼠均经气管内灌注博来霉素A5（5mg/kg）生理盐水溶液0.2～0.3mL，诱导肺纤维化。

Except the normal control group , other rats received 0.2-0.3 mL bleomycin A5 ( 5 mg / kg ) saline solution by perfusion via weasand to induce pulmonary fibrosis .

博来霉素致大鼠肺纤维化动物模型，腹腔注射H7后，定量RTPCR方法检测其对肺组织MCP1mRNA表达的影响；

The rat model for pulmonary fibrosis was induced by intratracheal instillation of bleomycin . After treated with H-7 , the level of MCP-1 mRNA expression was detected by the method of quantitative RT-PCR , and the content of hydroxyproline in lung tissues was determined .

结果用传统博来霉素法测定脐血浆NPBI值，无论在正常还是窒息新生儿均偏低，且其回收率只有32%左右。

Results The cord plasma NPBIs detected by traditional bleomycin assay got lower in both normal and asphyxial newborns and their recovery rates were only about 32 % .

Ortiz报道了骨髓来源干细胞可能减轻博来霉素诱导的肺纤维化，第一次提出骨髓来源的干细胞对肺组织疾病具有显著效果。

Ortiz et al have reported that bone marrow derived stem cells may be able to alleviate bleomycin induced fibrosis , this is the first study that has shown noticeable effect in stem cell derived cell therapy for pulmonary disease .

当归对博来霉素致鼠急性肺损伤的预防作用

Radix Angelica Sinensis Prevents Bleomycin Induced Acute Injury in Rats Lung

博来霉素-碘化油乳剂犬支气管栓塞的实验研究

The experimental study of intra-bronchus embolization of bleomycin-lipiodol emulsion in dogs

博来霉素A6对小鼠肺毒性的电子显微镜观察

An electron-microscopic study on pulmonary toxicity of bleomycin A_6 in mice

博来霉素A2+B2致小鼠肺纤维化作用的研究

Study of pulmonary fibrosis in mice induced by bleomycin A_2 + B_2

博来霉素与卡氮芥体外抑制颅咽管瘤的比较

Comparison inhibitory effect of bleomycin and carmustine on craniopharyngiomas cultured in vitro

博来霉素和石棉对肺泡巨噬细胞转录因子的活化作用

Bleomycin and asbestos induce activation of the nuclear factor-KB in alveolar macrophages

模型组大鼠予以1次性气管内注射博来霉素诱导肺纤维化模型，正常对照组大鼠于气管内注入等量生理盐水。

The pulmonary fibrosis was induced by intratracheal injection of BLM once .

方法：以博来霉素诱导建立小鼠肺纤维化模型，采用HE染色观察肺部胶原沉积状况。

METHODS : Pulmonary fibrosis model was induced by bleomycin in mice .

博来霉素治疗恶性胸腔积液52例

Treatment of 52 Cases of Malignant Pleural Effusion with Bleomycin

灯盏花素对博来霉素诱导小鼠肺纤维化的保护作用

Protective action of breviscapine against bleomycin-induced lung fibrosis in mice